Sustained sleep deprivation impairs host defense
Abstract
Prolonged sleep deprivation in rats causes an unexplained hypercatabolic state, secondary malnutrition symptoms, and mortality. The nature of the vital impairment has long been a mystery. Its determination would help to elucidate the type of organic dysfunction that sleep prevents. There are no gross detectable disturbances in intermediary metabolism, clinical chemistry, or hematological indexes that provide substantial clues to the mediation of sleep-deprivation effects. Furthermore, postmortem examinations reveal no systematic morphological or histopathological findings. Taken together, the cachexia and the absence of evidence of structural damage or organ dysfunction pointed to involvement of a regulatory system that was diffuse, possibly the immune system. Blood cultures revealed invasion by opportunistic microbes to which there was no febrile response. These results suggest that the life-threatening condition of prolonged sleep deprivation is a breakdown of host defense against indigenous and pathogenic microorganisms.
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In rats, sustained sleep deprivation induced oxidative stress as well as DNA, cell, and tissue damage.
“In rats, sustained sleep deprivation induced oxidative stress as well as DNA, cell, and tissue damage”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [173]
The cell injury in that study likely represents a condition of increased DAMP levels and DAMP-driven inflammation.
“likely representing a condition of increased DAMP levels and DAMP-driven inflammation”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [173]
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- Authors
- Everson, C. A.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Everson, C. A.
- ORCID
- Everson, C. A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1993-11-01
- Volume
- 265
- Issue
- 5
- Pages
- R1148-R1154
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W1863724130
- Cited by
- 251
- References
- 25
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 14 · 2014: 9 · 2013: 16 · 2012: 11
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, host defense, immune system, hypercatabolism, cachexia, malnutrition, mortality, rats
- MeSH terms
- Animals, Body Temperature, Body Weight, Electroencephalography, Electromyography, Feeding Behavior, Male, Reference Values, Sleep Deprivation, Sleep Stages, Theta Rhythm, Time Factors, Wakefulness, Rats, Sprague-Dawley, Rats
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