The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Sleep deprivation in the rat by the disk-over-water method
Abstract
Chronic sleep deprivation may be required to reveal the most serious physiological consequences of sleep loss, but it usually requires strong stimulation which can obscure the interpretation of effects. The disk-over-water method permits chronic sleep deprivation of rats with gentle physical stimulation that can be equally applied to yoked control rats. A series of studies with this method has revealed little or no pathology in the control rats. The deprived rats show a reliable syndrome that includes temperature changes (which vary with the sleep stages that are lost); heat seeking behavior; increased food intake; weight loss; increased metabolic rate; increased plasma norepinephrine; decreased plasma thyroxine; an increased triiodothyronine-thyroxine ratio; and an increase of an enzyme which mediates thermogenesis by brown adipose tissue. The temperature changes are attributable to excessive heat loss and an elevated thermoregulatory setpoint, both of which increase thermoregulatory load, and the other changes are interpretable as responses to this increased load. This pattern indicates that sleep serves a thermoregulatory function in the rat. The sleep deprived rats also show stereotypic ulcerative and hyperkeratotic lesions localized to the tail and plantar surfaces of the paws, and they die within a matter of weeks; the mediation of these changes is unresolved.
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“animals deprived of sleep for several weeks show temperature and weight dysregulation and ultimately die of infections and tissue lesions (973).”
From About Sleep's Role in Memory (2013) · cites this paper as [973]
In the citing paper
“conversely, total sleep deprivation leads to marked hyperphagia [133].”
From Sleep and metabolic function (2012) · cites this paper as [133]
Citations
Cites
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Self-citationSustained sleep deprivation impairs host defense
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Self-citationSleep Deprivation in the Rat: V. Energy Use and Mediation
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Self-citationSleep Deprivation in the Rat: VII. Immune Function
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Self-citationSleep Deprivation in the Rat: XIV. Comparison of Waking Hypothalamic and Peritoneal Temperatures
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Self-citationEffect of Total Sleep Deprivation on 5′-Deiodinase Activity of Rat Brown Adipose Tissue*
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Self-citationSleep Deprivation in the Rat:XII. Effect on Ambient Temperature Choice
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Self-citationExpression of Egr-1 in the brain of sleep deprived rats
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Self-citationSleep Deprivation in the Rat: XVIII. Regional Brain Levels of Monoamines and Their Metabolites
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Self-citationFeinberg, I., & Campbell, I. G. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.6.2695 · Cited by 23
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Self-citationOperant control of ambient temperature during sleep deprivation
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Self-citationSleep deprivation in rats with preoptic/anterior hypothalamic lesions
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Self-citationSleep Deprivation in the Rat: XVII. Effect of Aspirin on Elevated Body Temperature
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Self-citationSleep Deprivation in the Rat: XIII. The Effect of Hypothyroidism on Sleep Deprivation Symptoms
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Self-citation
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Short Sleep Duration and Weight Gain: A Systematic Review
Patel, S. R., & Hu, F. B. (2008) · Obesity · doi:10.1038/oby.2007.118 · Cited by 1,505
The metabolic consequences of sleep deprivation
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Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175
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Metadata
- Authors
- Rechtschaffen, A., & Bergmann, B. M.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Rechtschaffen, Allan
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 69
- Issue
- 1-2
- Pages
- 55-63
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2123138830
- Cited by
- 253
- References
- 36
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 13 · 2015: 8 · 2014: 7 · 2013: 19 · 2012: 17
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Chicago
- National Institutes of Health
- U.S. Public Health Service (ME 18428)
- National Institute of Mental Health (MH-4151)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, chronic sleep deprivation, thermoregulation, brown adipose tissue, thermogenesis, norepinephrine, thyroid hormones, dietary intake, weight loss, metabolic rate, ulcerative lesions, hyperkeratosis, sleep function
- MeSH terms
- Animals, Sleep Deprivation, Rats
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