Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement

Wolterink, G.; Phillips, G.; Cador, M.; Donselaar-Wolterink, I.; Robbins, T. W.; Everitt, B. J.

doi:10.1007/bf02251293

Cited by 158Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement

Wolterink, G., Phillips, G., Cador, M., Donselaar-Wolterink, I., Robbins, T. W., Everitt, B. J.·1993·Psychopharmacology

DOI 10.1007/bf02251293

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Abstract

Several experiments investigated the involvement of D1 and D2 dopamine receptors in the ventral striatum in the control over behaviour by a conditioned reinforcer using an acquisition of new response procedure. Intra-accumbens infusion of either the D1 receptor antagonist, SCH 23390, or the D2 receptor antagonist, raclopride, completely blocked the potentiative effects of intra-accumbens d-amphetamine on responding with conditioned reinforcement and reduced responding to control levels. SCH 23390 was more potent than raclopride. At higher doses in the absence of d-amphetamine, both antagonists also blocked the preference for responding on the lever producing the conditioned reinforcer. Intra-accumbens infusions of either the D1 receptor agonist, SKF 38393, or the D2/3 receptor agonist, LY 171555 (quinpirole), selectively potentiated responding on the lever producing the conditioned reinforcer. Various combined infusions of the D1 and D2 agonists in specific low doses had additive, but not synergistic, effects on responding with conditioned reinforcement. None of the drugs affected the drinking of water in deprived subjects when infused intra-accumbens. These results suggest that both D1 and D2 receptors in the nucleus accumbens are involved in mediating the effects of dopamine in potentiating the control over behaviour by conditioned reinforcers.

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Intra-accumbens injections of dopamine receptor antagonists or 6-OHDA treatments abolish conditioned reinforcement and attenuate amphetamine-enhanced conditioned reinforcement.
“Furthermore, intra-accumbens injections of dopamine receptor antagonists or 6-OHDA treatments abolishes conditioned reinforcement (Robbins and Everitt, 1982) and attenuate amphetamine-enhanced conditioned reinforcement (Taylor and Robbins, 1986; Wolterink et al., 1993).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Wolterink et al., 1993

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Authors: Wolterink, G., Phillips, G., Cador, M., Donselaar-Wolterink, I., Robbins, T. W., & Everitt, B. J.
Affiliations: University of Cambridge (GB)
Inserm (FR)
ORCID: Wolterink, G.
Cador, M.
Robbins, T. W.
Everitt, B. J.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1993-02
Volume: 110
Issue: 3
Pages: 355-364
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf02251293
OpenAlex: W2021496139
Cited by: 158
References: 54
Citations by year: 2025: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 1
FWCI: 2.16
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine D1 receptor, dopamine D2 receptor, ventral striatum, nucleus accumbens, conditioned reinforcement, d-amphetamine, SCH 23390, raclopride, SKF 38393, quinpirole, dopamine agonists, dopamine antagonists
MeSH terms: Animals, Conditioning, Operant, Dextroamphetamine, Dose-Response Relationship, Drug, Ergolines, Male, Nucleus Accumbens, Reinforcement, Psychology, Salicylamides, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Neostriatum, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Quinpirole, Raclopride, Rats

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Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement

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