Cited by 94Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Senile plaques in aged squirrel monkeys

Walker, Lary C., Kitt, Cheryl A., Schwam, Elias, Buckwald, Beth, Garcia, Felix, Sepinwall, Jerry, Price, Donald L.·1987·Neurobiology of Aging

Abstract

Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.

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Crossref · 10.1016/0197-4580(87)90067-4

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29 of 29 references verified0 citation errors · 0 not checkable

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  • Squirrel monkeys have extensive Aβ accumulation after 12 years of age, primarily in the form of CAA in arterioles and capillaries.

    “Squirrel monkeys have extensive Aβ accumulation after 12 years of age, primarily in the form of CAA in arterioles and capillaries [22, 36, 167, 168].”

    From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [167]

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Authors
Walker, L. C., Kitt, C. A., Schwam, E., Buckwald, B., Garcia, F., Sepinwall, J., & Price, D. L.
Affiliations
Johns Hopkins University (US)
Corresponding author
Walker, Lary C.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1987-07
Volume
8
Issue
4
Pages
291-296
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2087883041
Cited by
94
References
29
Citations by year
2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2013: 2 · 2012: 1
FWCI
4.71
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Institute on Aging (AG 05146)
  • National Institute of Neurological Disorders and Stroke (NS-07179, NS-20471)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
amyloid plaques, squirrel monkey, brain aging, amyloid core, phosphorylated neurofilament, neuropeptide Y, temporal lobe, amygdala, hippocampal formation, frontal cortex
MeSH terms
Aging, Amyloid, Animals, Brain, Brain Chemistry, Female, Histocytochemistry, Immunoenzyme Techniques, Intermediate Filaments, Macaca mulatta, Male, Neuropeptide Y, Saimiri

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