Senile plaques in aged squirrel monkeys
Abstract
Aged squirrel monkeys develop senile plaques in the brain that are similar to those occurring in aged rhesus monkeys and aged humans. These plaques consist of abnormal, swollen neurites around an amyloid core. In whole-hemisphere coronal sections through the level of the rostral temporal lobe, plaques are present in temporal cortex, amygdala, hippocampal formation and, occasionally, in other cortical regions. In more rostral sections through the frontal lobe, plaques are most common in orbitofrontal and frontal opercular cortical regions. In immunocytochemical preparations, some neurites show immunoreactivity with antibodies directed against phosphorylated neurofilaments and neuropeptide Y. Thus, plaques in these New World primates are similar in distribution and composition to those occurring in aged Old World primates.
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Squirrel monkeys have extensive Aβ accumulation after 12 years of age, primarily in the form of CAA in arterioles and capillaries.
“Squirrel monkeys have extensive Aβ accumulation after 12 years of age, primarily in the form of CAA in arterioles and capillaries [22, 36, 167, 168].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [167]
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Self-citationNon-human Primate Models of Alzheimer’s Disease
Li, Y., & Gu, B. J. (2023) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2023.00006 · Cited by 8 · see citing works
Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys
Darusman, H. S., Agungpriyono, D. R., Kusumaputri, V. A., Sajuthi, D., Schapiro, S. J., & Hau, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00050 · Cited by 8 · see citing works
Chapter 25 Neuronal responses to injury and aging: lessons from animal models
Price, D. L., Koo, E. H., Sisodia, S. S., Martin, L. J., Koliatsos, V. E., Muma, N. A., Walker, L. C., & Cork, L. C. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)63186-6 · Cited by 8 · see citing works
Self-citationComparative neuropathology of aged nonhuman primates
Walker, L. C. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90064-i · Cited by 8 · see citing works
Self-citationBarnes, C. A., Permenter, M. R., Vogt, J. A., Chen, K.-W., & Beach, T. (2024) · The Journal of comparative neurology · doi:10.1002/cne.25670 · Cited by 7 · see citing works
Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders
Colwell, J. C., & Emborg, M. E. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1598245 · Cited by 9 · see citing works
Shen, Y., & Li, R. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00455-3 · Cited by 7 · see citing works
Primate Models for Dietary Restriction Research
Roth, G. S., Ingram, D. K., & Cutler, R. G. (1991) · Springer eBooks · doi:10.1007/978-3-642-58181-6_27 · Cited by 7 · see citing works
CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS
Sisodia, S. S., Martin, L. J., Walker, L. C., Borchelt, D., & Price, D. L. (1995) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00276-x · Cited by 6 · see citing works
Self-citationWhat we have learned from non-human primates as animal models of epilepsy
Sanabria, V., Romariz, S. A. A., Braga, M., Pires, J. M., Naffah‐Mazzacoratti, M. D. G., Mello, L. E., Longo, B. M., & Foresti, M. L. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.109706 · Cited by 5 · see citing works
Amyloid-β Pathology Is the Common Nominator Proteinopathy of the Primate Brain Aging
Ferrer, I. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240389 · Cited by 6 · see citing works
Alzheimer disease-like neuropathologic changes in a geriatric baboon (Papio hamadryas)
Harrison, W. T., Cline, J. M., Caudell, D. L., Huber, H. F., Shively, C. A., Register, T. C., Craft, S., & Struthers, J. D. (2024) · Journal of Veterinary Science · doi:10.4142/jvs.24080 · Cited by 3 · see citing works
Pathology, Neurobiology, and Animal Models of Alzheimer's Disease
Sisodia, S. S., Price, D. D., Crain, B. J., & Troncoso, J. C. (1996) · Informa Healthcare eBooks · doi:10.1201/9781420048407.ch12 · Cited by 3 · see citing works
Self-citationNeuronal Disorders: Studies of Animal Models and Human Diseases
Price, D. L., Sisodia, S. S., Koo, E. H., Muma, N. A., Kitt, C. A., Walker, L. C., Martin, L. J., Troncoso, J. C., Griffin, J. W., Hoffman, P. N., et al. (1990) · Toxicologic Pathology · doi:10.1177/019262339001800118 · Cited by 3 · see citing works
Self-citationAnimal Models of Alzheimer’s Disease
Dunnett, S. B. (1994) · Springer eBooks · doi:10.1007/978-1-4615-6805-6_14 · Cited by 3 · see citing works
Nonhuman Primate Models in Trophic Factor Research
Koliatsos, V. E., & Price, D. L. (2003) · Humana Press eBooks · doi:10.1385/0-89603-249-3:331 · Cited by 3 · see citing works
Self-citationRelationships Between Aging and Neurodegenerative Disease
Mann, D. M. A. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6001-2_5 · Cited by 1 · see citing works
Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease
Price, D. L., Koo, E. H., Sisodia, S. S., Martin, L. J., Walker, L. C., Kitt, C. A., & Cork, L. C. (1990) · Key topics in brain research · doi:10.1007/978-3-7091-3396-5_14 · Cited by 1 · see citing works
Self-citationAmyloid in Alzheimer’s Disease and Animal Models
Price, D. L., Lamb, B. T., Gearhart, J. D., Martin, L. J., Walker, L. C., Koo, E. H., Borchelt, D., & Sisodia, S. S. (1994) · Springer eBooks · doi:10.1007/978-3-662-01135-5_15 · Cited by 1 · see citing works
Self-citationAlzheimer’s Disease and Animal Models
Price, D. L., Martin, L. J., Koo, E. H., Sisodia, S. S., Koliatsos, V. E., & Cork, L. C. (1990) · Springer eBooks · doi:10.1007/978-3-642-84224-5_15 · Cited by 1 · see citing works
Self-citationGenetically Engineered Models of Human Age-Related Neurodegenerative Diseases
Vickers, J. C. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50027-5 · Cited by 1 · see citing works
Sołtysiak, Z., Barcikowska, M., Gajda, M., & Pawlas, M. (2006) · Medycyna Weterynaryjna
Cellular and animal models of amyloid β-protein amyloidosis
Sisodia, S. S., Borchelt, D., & Price, D. L. (1995) · Elsevier eBooks · doi:10.1016/b978-012286965-5/50012-1
Self-citationAuboyer, L. (2018) · theses.fr (ABES) · doi:10.70675/07243ef7zb974z4ad8z97d9zd046801798b1
The Effects of Nerve Growth Factor on the Central Nervous System of the Adult Primate
Koliatsos, V. E., Clatterbuck, R. E., Gouras, G. K., & Price, D. L. (1991) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4899-6738-1_47
Self-citation
- Authors
- Walker, L. C., Kitt, C. A., Schwam, E., Buckwald, B., Garcia, F., Sepinwall, J., & Price, D. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Walker, Lary C.
- ORCID
- Walker, Lary C.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 8
- Issue
- 4
- Pages
- 291-296
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2087883041
- Cited by
- 94
- References
- 29
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2013: 2 · 2012: 1
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute on Aging (AG 05146)
- National Institute of Neurological Disorders and Stroke (NS-07179, NS-20471)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid plaques, squirrel monkey, brain aging, amyloid core, phosphorylated neurofilament, neuropeptide Y, temporal lobe, amygdala, hippocampal formation, frontal cortex
- MeSH terms
- Aging, Amyloid, Animals, Brain, Brain Chemistry, Female, Histocytochemistry, Immunoenzyme Techniques, Intermediate Filaments, Macaca mulatta, Male, Neuropeptide Y, Saimiri
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