The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
Open accessAbstract
It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.
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“A plethora of studies document increased levels of both SSBs and DSBs in AD, HD, PD, and ALS (Mullaart et al, 1990; Adamec et al, 1999; McKinnon, 2013, 2017; Madabhushi et al, 2014; Alt & Schwer, 2018; Shanbhag et al, 2019; Thadathil et al, 2021), and their accumulation seem to correlate with important milestones in disease progression.”
From Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease (2022) · cites this paper as Mullaart et al, 1990
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“In AD, a two-fold increase in DNA damage has been found in the cortex compared to healthy controls [113].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [113]
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Cites
Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field
Carle, G. F., Frank, M. B., & Olson, M. V. (1986) · Science · doi:10.1126/science.3952500 · Cited by 914
Fractionation of DNA from mammalian cells by alkaline elution
Kohn, K. W., Erickson, L. C., Ewig, R. A. G., & Friedman, C. A. (1976) · Biochemistry · doi:10.1021/bi00666a013 · Cited by 828
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772
Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.
Regan, J. D., & Setlow, R. B. (1974) · PubMed · Cited by 440
CONGENITAL HEMIHYPERTROPHY AND MALIGNANCY
Benson, P. F., Vulliamy, D. G., & Taubman, J. O. (1963) · The Lancet · doi:10.1016/s0140-6736(63)92360-2 · Cited by 291
Martins, R. N., Harper, C. G., Stokes, G. B., & Masters, C. L. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00615.x · Cited by 234
Biological Aspects of Alzheimer's Disease
(1984) · Journal of Gerontology · doi:10.1093/geronj/39.5.630a · Cited by 203
Hardy, J. A., Wester, P., Winblad, B., Gezelius, C., Bring, G., & Eriksson, A. (1985) · Journal of Neural Transmission · doi:10.1007/bf01251916 · Cited by 185
Alzheimer's Disease Brain: Alterations in RNA Levels and in a Ribonuclease-Inhibitor Complex
Sajdel-Sulkowska, E. M., & Marotta, C. A. (1984) · Science · doi:10.1126/science.6206567 · Cited by 181
Parkinson's disease and Alzheimer's disease: hypersensitivity to X rays in cultured cell lines.
Robbins, J. H., Otsuka, F., Tarone, R. E., Polinsky, R. J., Brumback, R. A., & Nee, L. E. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.9.916 · Cited by 100
Research works printed but not linked: 1
- Kinsella, 1987, Alzheimer's disease fibroblasts have normal repair of methylmethane sulfate-induced DNA damage determined by the alkaline elution technique, Neurology, 37, 166
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Sorted by citations
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357
Antioxidants and Prevention of Chronic Disease
Willcox, J. K., Ash, S. L., & Catignani, G. L. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490468489 · Cited by 1,200
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037
Oxidative stress in Alzheimer’s disease
Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797
Metadata
- Authors
- Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F., & Vijg, J.
- Affiliations
- Netherlands Organisation for Applied Scientific Research (NL)
- Corresponding author
- Vijg, Jan
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 11
- Issue
- 3
- Pages
- 169-173
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2072092279
- Cited by
- 201
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 5 · 2020: 16 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 5
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- pure.knaw.nl
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- TNO Repository (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, DNA damage, DNA strand breaks, cerebral cortex, alkali-labile sites, DNA repair, neuronal DNA damage, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, DNA Damage, Female, Humans, Male, Middle Aged
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