Cited by 201Alzheimer's disease research and treatmentsDNA Repair MechanismsDementia and Cognitive Impairment Research

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Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

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Mullaart, Erik, Boerrigter, Michael E.T.I., Ravid, Rivka, Swaab, Dick F., Vijg, Jan·1990·Neurobiology of Aging

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Abstract

It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

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Authors: Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F., & Vijg, J.
Affiliations: Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author: Vijg, Jan
ORCID: Mullaart, Erik
Swaab, Dick F.
Vijg, Jan
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1990-05
Volume: 11
Issue: 3
Pages: 169-173
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(90)90542-8
OpenAlex: W2072092279
Cited by: 201
References: 34
Citations by year: 2026: 1 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 5 · 2020: 16 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 5
FWCI: 1.61
Type: journal article
Language: en
Open access: green
pure.knaw.nl
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
TNO Repository (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, DNA damage, DNA strand breaks, cerebral cortex, alkali-labile sites, DNA repair, neuronal DNA damage, neuropathology
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, DNA Damage, Female, Humans, Male, Middle Aged

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Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

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