Cited by 538Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMemory and Neural Mechanisms

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Memory improvement following induced hyperinsulinemia in Alzheimer’s disease

Craft, Suzanne, Newcomer, John, Kanne, Stephen, Dagogo-Jack, Samuel, Cryer, Philip, Sheline, Yvette, Luby, Joan, Dagogo-Jack, Agbani, Alderson, Amy·1996·Neurobiology of Aging

DOI 10.1016/0197-4580(95)02002-0

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Abstract

Dementia of the Alzheimer type (DAT) is accompanied by disruption in glucose regulation and utilization that may contribute to its characteristic memory impairment. Increasing glucose availability by raising plasma glucose improves memory in patients with DAT. Such memory improvement is associated with a secondary elevation in plasma insulin levels, raising the question of whether improvement is due to changes in insulin levels, independent of hyperglycemia. Distributions of insulin receptors in the hippocampus and insulin-mediated increases in glucose utilization in entorhinal cortex provide potential mechanisms for such improvement. We show that raising plasma insulin through intravenous infusion while keeping plasma glucose at a fasting baseline level produces striking memory enhancement for patients with DAT. Previous findings of hyperglycemic memory enhancement were also replicated. Patients with DAT also showed abnormal plasma levels of glucoregulatory hormones and metabolites at baseline and during metabolic manipulations. Our findings suggest that neuroendocrine factors play an important role in the pathophysiology of DAT.

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Authors: Craft, S., Newcomer, J., Kanne, S., Dagogo-Jack, S., Cryer, P., Sheline, Y., Luby, J., Dagogo-Jack, A., & Alderson, A.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Craft, Suzanne
ORCID: Craft, Suzanne
Newcomer, John
Kanne, Stephen
Dagogo-Jack, Samuel
Sheline, Yvette
Luby, Joan
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1996-01
Volume: 17
Issue: 1
Pages: 123-130
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(95)02002-0
OpenAlex: W2101048381
Cited by: 538
References: 41
Citations by year: 2026: 9 · 2025: 32 · 2024: 45 · 2023: 28 · 2022: 21 · 2021: 29 · 2020: 42 · 2019: 25 · 2018: 17 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 17 · 2012: 17
FWCI: 12.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k20mh001045-01)
National Institute on Aging (R01-AG-10880, R01AG010880)
National Institute of Mental Health (MH-01045)
National Center for Research Resources (MO1RR00036, M01RR000036)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Alzheimer's disease, hyperinsulinemia, memory impairment, insulin, glucose regulation, hyperglycemia, hippocampus, insulin receptor, entorhinal cortex, glucoregulatory hormones, neuroendocrine factors
MeSH terms: Aged, Alzheimer Disease, Fatty Acids, Glucagon, Humans, Hyperglycemia, Hyperinsulinism, Lactates, Memory, Norepinephrine, Psychiatric Status Rating Scales

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Memory improvement following induced hyperinsulinemia in Alzheimer’s disease

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