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Memory improvement following induced hyperinsulinemia in Alzheimer’s disease
Abstract
Dementia of the Alzheimer type (DAT) is accompanied by disruption in glucose regulation and utilization that may contribute to its characteristic memory impairment. Increasing glucose availability by raising plasma glucose improves memory in patients with DAT. Such memory improvement is associated with a secondary elevation in plasma insulin levels, raising the question of whether improvement is due to changes in insulin levels, independent of hyperglycemia. Distributions of insulin receptors in the hippocampus and insulin-mediated increases in glucose utilization in entorhinal cortex provide potential mechanisms for such improvement. We show that raising plasma insulin through intravenous infusion while keeping plasma glucose at a fasting baseline level produces striking memory enhancement for patients with DAT. Previous findings of hyperglycemic memory enhancement were also replicated. Patients with DAT also showed abnormal plasma levels of glucoregulatory hormones and metabolites at baseline and during metabolic manipulations. Our findings suggest that neuroendocrine factors play an important role in the pathophysiology of DAT.
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“Neuronal IRs are involved in diverse brain functions including synapse plasticity, learning and memory (Chiu et al., 2008; Craft et al., 1996; Kern et al., 2001; Lee et al., 2005; Park et al., 2000).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Craft et al., 1996
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. L., & Stadlan, E. (2011) · Neurology · doi:10.1212/01.wnl.0000400650.92875.cf · Cited by 9,882
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
(1995) · Cited by 2,809
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Benton, A. L. (1978) · Archives of Neurology · doi:10.1001/archneur.1978.00500300038006 · Cited by 1,026
Perret, E. (1974) · Neuropsychologia · doi:10.1016/0028-3932(74)90047-5 · Cited by 1,007
Insulin in the Brain: A Hormonal Regulator of Energy Balance*
Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C., & Porte, D. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-3-387 · Cited by 808
Simpson, I. A., Chundu, K. R., Davies‐Hill, T., Honer, W. G., & Davies, P. (1994) · Annals of Neurology · doi:10.1002/ana.410350507 · Cited by 490
The Impact of Diabetes on the CNS
McCall, A. L. (1992) · Diabetes · doi:10.2337/diab.41.5.557 · Cited by 340
Research works printed but not linked: 3
- Henderson, 1994, Estrogen replacement therapy and neuropsychological performance in women with probable Alzheimer's disease: A case-control study, Neurology, 44, A158
- Mortel, 1994, Estrogen replacement therapy and risk of dementia, Neurology, 44, A208
- Paganini-Hill, 1993, Estrogen replacement and Alzheimer's disease in women, Soc. Neurosci. Abs., 19, 1046
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Self-citationAbbott, M.-A., Wells, D. G., & Fallon, J. R. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07300.1999 · Cited by 327
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Farris, W., Mansourian, S., Leissring, M. A., Eckman, E. A., Bertram, L., Eckman, C. B., Tanzi, R. E., & Selkoe, D. J. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63229-4 · Cited by 269
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Watson, G. S., Peskind, E. R., Asthana, S., Purganan, K., Wait, C., Chapman, D., Schwartz, M. W., Plymate, S. R., & Craft, S. (2003) · Neurology · doi:10.1212/01.wnl.0000065916.25128.25 · Cited by 265
Self-citationSoucek, T., Cumming, R., Dargusch, R., Maher, P., & Schubert, D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00367-2 · Cited by 258
Rabin, L. A., Paré, N., Saykin, A. J., Brown, M. J., Wishart, H. A., Flashman, L. A., & Santulli, R. B. (2009) · Aging, Neuropsychology, and Cognition · doi:10.1080/13825580902825220 · Cited by 256
Craft, S., Asthana, S., Cook, D. G., Baker, L. D., Cherrier, M. M., Purganan, K., Wait, C., Petrova, A., Latendresse, S. J., Watson, G. S., et al. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00087-2 · Cited by 254
Self-citationBates, K. A., Verdile, G., Li, Q.-X., Ames, D., Hudson, P., Masters, C. L., & Martins, R. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.96 · Cited by 247
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Kaplan, R. J., Greenwood, C. E., Winocur, G., & Wolever, T. M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.825 · Cited by 193
Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.022 · Cited by 191
Craft, S., Asthana, S., Schellenberg, G., Baker, L., Cherrier, M., Boyt, A. A., Martins, R., Raskind, M., Peskind, E., & Plymate, S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06371.x · Cited by 200
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Smith, M., Riby, L. M., van Eekelen, J. A. M., & Foster, J. K. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.008 · Cited by 176
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Wickelgren, I. (1998) · Science · doi:10.1126/science.280.5363.517 · Cited by 169
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Wang, X., Zheng, W. H., Xie, J., Wang, T., Wang, S., Teng, W., & Wang, Z. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-46 · Cited by 161
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Craft, S., Asthana, S., Schellenberg, G., Cherrier, M., Baker, L. D., Newcomer, J., Plymate, S., Latendresse, S., Petrova, A., Raskind, M., et al. (1999) · Neuroendocrinology · doi:10.1159/000054469 · Cited by 154
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Rosendorff, C., Beeri, M. S., & Silverman, J. M. (2007) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2007.06696.x · Cited by 154
Lamport, D. J., Lawton, C. L., Mansfield, M. W., & Dye, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.008 · Cited by 156
Conroy, S. K., McDonald, B. C., Smith, D. J., Moser, L. R., West, J. D., Kamendulis, L. M., Klaunig, J. E., Champion, V. L., Unverzagt, F. W., & Saykin, A. J. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2385-x · Cited by 147
Dahl, M. J., Mather, M., Werkle‐Bergner, M., Kennedy, B. L., Guzman, S. J., Hurth, K. M., Miller, C. A., Qiao, Y., Shi, Y., Chui, H. C., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.11.006 · Cited by 149
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Metadata
- Authors
- Craft, S., Newcomer, J., Kanne, S., Dagogo-Jack, S., Cryer, P., Sheline, Y., Luby, J., Dagogo-Jack, A., & Alderson, A.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Craft, Suzanne
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 17
- Issue
- 1
- Pages
- 123-130
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2101048381
- Cited by
- 538
- References
- 41
- Citations by year
- 2026: 9 · 2025: 32 · 2024: 45 · 2023: 28 · 2022: 21 · 2021: 29 · 2020: 42 · 2019: 25 · 2018: 17 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 17 · 2012: 17
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1k20mh001045-01)
- National Institute on Aging (R01-AG-10880, R01AG010880)
- National Institute of Mental Health (MH-01045)
- National Center for Research Resources (MO1RR00036, M01RR000036)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, hyperinsulinemia, memory impairment, insulin, glucose regulation, hyperglycemia, hippocampus, insulin receptor, entorhinal cortex, glucoregulatory hormones, neuroendocrine factors
- MeSH terms
- Aged, Alzheimer Disease, Fatty Acids, Glucagon, Humans, Hyperglycemia, Hyperinsulinism, Lactates, Memory, Norepinephrine, Psychiatric Status Rating Scales
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