Cited by 836Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

McGeer, Patrick L., Itagaki, Shigeru, Tago, Hisao, McGeer, Edith G.·1987·Neuroscience Letters

DOI 10.1016/0304-3940(87)90696-3

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Abstract

HLA-DR is a class II cell surface glycoprotein of the human histocompatibility complex usually expressed on the surface of cells that are simultaneously presenting foreign antigen to T-lymphocytes. Using immunohistochemical procedures with two specific monoclonal antibodies to HLA-DR, HLA-DR-positive reactive microglia were found in gray matter throughout the cortex of postmortem brains of patients with senile dementia of the Alzheimer type (SDAT) and were particularly concentrated in the areas of senile plaque formation. Double immunostaining with antibodies to glial fibrillary acidic protein (GFAP) showed that the HLA-DR-positive cells were different from the reactive astrocytes although the occasional positively staining giant astrocyte was also seen. Small numbers of resting microglia were HLA-DR-positive in white matter of both normal and SDAT brains. The SDAT cases also had reduced cortical choline acetyltransferase (ChAT) levels. In the 11 brains studied, the number of hippocampal HLA-DR-positive cells was positively correlated with the numbers of plaques and negatively correlated with average cortical ChAT.

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Handbook of Histopathological and Histochemical Techniques
(1974) · Elsevier eBooks · doi:10.1016/c2013-0-04011-x · Cited by 508
THE DETAILED DISTRIBUTION OF MHC CLASS II ANTIGENS IN NORMAL HUMAN ORGANS
Daar, A. S., Fuggle, S., Fabre, J. W., Ting, A., & Morris, P. J. (1984) · Transplantation · doi:10.1097/00007890-198409000-00019 · Cited by 432
Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement.
Lampson, L. A., & Hickey, W. F. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.11.4054 · Cited by 230
Interferon-γ induces the expression of H-2 and Ia antigens on brain cells
Wong, G. H., Bartlett, P. F., Clark‐Lewis, I., McKimm‐Breschkin, J. L., & Schrader, J. W. (1984) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(84)80026-0 · Cited by 181
Distribution of choline acetyltransferase-containing neurons of the hypothalamus
Tago, H., McGeer, P. L., Bruce, G., & Hersh, L. B. (1987) · Brain Research · doi:10.1016/0006-8993(87)90268-x · Cited by 142
Self-citation
The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry
Mizukawa, K., McGeer, P. L., Tago, H., Peng, J. H., McGeer, E. G., & Kimura, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)90253-2 · Cited by 120
Self-citation
Demonstration of HLA-DR antigens in normal human brain.
de Tribolet, N., Hamou, M., Mach, J. P., Carrel, S., & Schreyer, M. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.4.417 · Cited by 57
Immunofluorescence studies of the monocytes in the injured rat brain
Tsuchihashi, Y., Kitamura, T., & Fujita, S. (1981) · Acta Neuropathologica · doi:10.1007/bf00688024 · Cited by 48
γ-GLUTAMYLTRANSFERASE
McGeer, E. G., Singh, E. A., & McGeer, P. L. (1987) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198701000-00005 · Cited by 15
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Show all 9 references

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McGeer, 1987, Biochemistry and pathology of the basal ganglia, Can. J. Neurol. Sci., 19
del Rio Hortega, 1932, Microglia, Vol. 2, 483
Tago, H., McGeer, P.L., Bruce, G. and Hersh, L.B., Distribution of cholineacetyltransferase-containing neurons of the hypothalamus, Brain Res., in press.

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Smits, H. A., Vos, N., Wat, J. W. Y., van der Bruggen, T., Verhoef, J., & Nottet, H. S. L. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00254-5 · Cited by 23
Alzheimer's disease cerebrospinal fluid antibodies display selectivity for microglia
Dahlström, A. B., McRae‐Degueurce, A., Polinsky, R. J., Nee, L. E., Sadasivan, B., & Ling, E. A. (1994) · Molecular Neurobiology · doi:10.1007/bf02816104 · Cited by 19
Examination of brains of AIDS cases for human immunodeficiency virus and human cytomegalovirus nucleic acids.
Walker, D. G., Itagaki, S., Berry, K., & McGeer, P. L. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.5.583 · Cited by 19
Self-citation
Alzheimer’s disease basics: we all should know
Das, S. K. (2025) · Neurological Research · doi:10.1080/01616412.2025.2529560 · Cited by 19
Amyloid-β(1−42) Fibrillar Precursors Are Optimal for Inducing Tumor Necrosis Factor-α Production in the THP-1 Human Monocytic Cell Line
Ajit, D., Udan, M. L. D., Paranjape, G. S., & Nichols, M. R. (2009) · Biochemistry · doi:10.1021/bi9003777 · Cited by 18
Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer’s Disease Patients
Ju, T., Sun, L., Fan, Y., Wang, T., Liu, Y., Liu, D., Liu, T., Zhao, C. W., Wang, W., & Chi, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.762649 · Cited by 18
COVID‐19 and the impact on Alzheimer's disease pathology
Furman, S., Green, K. N., & Lane, T. E. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15985 · Cited by 18
Ccr2-64i and Ccr5 Δ32 Polymorphisms in Patients with Late-Onset Alzheimer's disease; A Study from Iran (Ccr2-64i And Ccr5 Δ32 Polymorphisms in Alzheimer's disease).
Khorshid, H. R. K., Manoochehri, M., Nasehi, L., Ohadi, M., Rahgozar, M., & Kamali, K. (2012) · Europe PMC (PubMed Central) · Cited by 19
Investigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer’s Disease
Jorge, L., Martins, R., Canário, N., Xavier, A. C., Abrunhosa, A., Santana, I. J., & Castelo-Branco, M. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200840 · Cited by 19
Demonstration of fibroblast growth factor receptor‐I in human prostate by polymerase chain reaction and immunohistochemistry
Hamaguchi, A., Tooyama, I., Yoshiki, T., & Kimurâ, H. (1995) · The Prostate · doi:10.1002/pros.2990270304 · Cited by 18
Early complement activation increases in the brain in some aged normal subjects
Loeffler, D. A., Camp, D. M., Schonberger, M. B., Singer, D. J., & LeWitt, P. A. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.003 · Cited by 18
Expression of CD43 in human microglia and its downregulation in Alzheimer's disease
Matsuo, A., Walker, D. G., Terai, K., & McGeer, P. L. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00134-8 · Cited by 18
Self-citation
Antibody in the CSF of patients with multiple system atrophy reacts specifically with rat locus ceruleus
Polinsky, R. J., McRae‐Degueurce, A., Baser, S. M., & Dahlström, A. B. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90201-h · Cited by 18
Cerebrospinal fluid microglial antibodies: Potential diagnostic markers for immune mechanisms in Alzheimer's disease
McRae‐Degueurce, A., Dahlström, A. B., Polinsky, R. J., & Ling, E. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90139-h · Cited by 18
Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease
Guo, F., Sheng, Z.-H., Fu, Y., Wang, Z., Xue, R., Tan, M., Tan, M.-S., & Wang, Z.-T. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03458-5 · Cited by 21
Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)
Tolédano, A., Rodríguez‐Casado, A., Álvarez, M., & Toledano‐Díaz, A. (2024) · Brain Sciences · doi:10.3390/brainsci14111101 · Cited by 19
Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant
Tambini, M. D., & D'adamio, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-60800-1 · Cited by 16
Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis
Manocha, G. D., Puig, K. L., Austin, S. A., Seyb, K. I., Glicksman, M. A., & Combs, C. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132604 · Cited by 17
Neuroinflammation and Alzheimer’s Disease
Eikelenboom, P. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5405-9_3 · Cited by 17
Peripheral blood lymphocyte subset distribution and function in patients with Alzheimer's disease and other dementias
Hu, G., Walls, R. S., Creasey, H. M., McCusker, E. A., & Broe, G. A. (1995) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1995.tb01525.x · Cited by 17
Immunophenotypic features of epiplexus cells and their response to interferon gamma injected intraperitoneally in postnatal rats.
Lu, J., Kaur, C., & Ling, E. (1994) · PubMed · Cited by 17

Authors: McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G.
Affiliations: University of British Columbia (CA)
Corresponding author: McGeer, Patrick L.
ORCID: McGeer, Patrick L.
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1987-08
Volume: 79
Issue: 1-2
Pages: 195-200
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(87)90696-3
OpenAlex: W2074274825
Cited by: 836
References: 9
Citations by year: 2026: 7 · 2025: 19 · 2024: 24 · 2023: 36 · 2022: 32 · 2021: 30 · 2020: 40 · 2019: 31 · 2018: 26 · 2017: 28 · 2016: 21 · 2015: 27 · 2014: 34 · 2013: 27 · 2012: 27
FWCI: 14.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: reactive microglia, HLA-DR, senile dementia of the Alzheimer type, Alzheimer's disease, amyloid plaques, glial fibrillary acidic protein, astrocytes, choline acetyltransferase, hippocampus, neuroinflammation
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Hippocampus, HLA-D Antigens, HLA-DR Antigens, Humans, Neuroglia

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

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