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Cited by 272Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Agonists of cholinergic and noradrenergic receptors facilitate synergistically the induction of long-term potentiation in slices of rat visual cortex

Bröcher, Susanne, Artola, Alain, Singer, Wolf·1992·Brain Research
DOI 10.1016/0006-8993(92)90110-u
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Abstract

Acetylcholine (ACh) and noradrenaline (NA) have been shown to facilitate experience-dependent modifications of synaptic connectivity during postnatal development of the kitten visual cortex. To further investigate the mechanisms of this facilitation we studied the effects of these neuromodulators in an in vitro model of use-dependent synaptic plasticity. We have chosen long-term potentiation (LTP) in rat visual cortex slices because it shares several features with the in vivo model. In both cases induction of synaptic modifications requires that postsynaptic activation reaches a critical threshold and in both cases changes are induced more easily in young animals and when N-methyl-D-aspartate (NMDA) receptor-gated conductances are activated. Intracellular recordings were obtained from regular spiking cells in supragranular layers of rat visual cortex and LTP was induced by tetanic stimulation of the underlying white matter. Both cholinergic and noradrenergic agonists raised the probability that tetanic stimuli induced LTP and as in vivo they acted synergistically. These effects were mediated by agonists of muscarinic and beta-receptors, respectively. The agonists of both receptor systems enhanced the depolarizing response to the tetanus and increased NMDA receptor-gated conductances during this response. We suggest that this mode of action also accounts for the facilitatory effects which ACh and NA have on use-dependent synaptic plasticity in the developing visual cortex.

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  • Ascending neuromodulatory neurotransmitter systems, such as dopaminergic and cholinergic projections, have exactly the right characteristics: they are driven by activity in presynaptic connections and can affect activity through classical neuromodulatory effects at the post-synaptic membrane, while also enabling potentiation of connection strengths.

    “Happily, the ascending neuromodulatory neurotransmitter systems, such as dopaminergic and cholinergic projections, have exactly the right characteristics: they are driven by activity in presynaptic connections and can affect activity though classical neuromodulatory effects at the post-synaptic membrane [65], while also enabling potentiation of connection strengths [66],[67].”

    From Hierarchical Models in the Brain (2008) · cites this paper as [66]

  • Neuromodulatory factors play a dual role in modulating postsynaptic responsiveness and synaptic plasticity.

    “Neuromodulatory factors play a dual role in modulating postsynaptic responsiveness (e.g., through modulating in after-hyperpolarising currents) and synaptic plasticity [66],[67].”

    From Hierarchical Models in the Brain (2008) · cites this paper as [66]

  • Histamine, norepinephrine, and acetylcholine support induction and maintenance of LTP.

    “Supporting effects on the induction and maintenance of LTP were also consistently revealed for histamine (677, 750), norepinephrine, as well as acetylcholine (140, 585, 598, 1187, 1309).”

    From About Sleep's Role in Memory (2013) · cites this paper as [140]

  • Norepinephrine and acetylcholine are important for induction of late LTP and often synergistically enhance LTP and LTD.

    “Indeed, norepinephrine and acetylcholine are also important for the induction of late LTP (12,1295) and were often found to synergistically act to enhance LTP (140, 1309) as well as LTD (642).”

    From About Sleep's Role in Memory (2013) · cites this paper as [140]

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Authors
Bröcher, S., Artola, A., & Singer, W.
Affiliations
Max Planck Institute for Brain Research (DE)
Corresponding author
Artola, Alain
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
1992-02
Volume
573
Issue
1
Pages
27-36
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(92)90110-u
OpenAlex
W2035322026
Cited by
272
References
4
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 8 · 2013: 6 · 2012: 20
FWCI
4.62
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
long-term potentiation, cholinergic receptors, noradrenergic receptors, acetylcholine, norepinephrine, muscarinic receptors, beta-adrenergic receptors, visual cortex, synaptic plasticity, tetanic stimulation, neuromodulation
MeSH terms
Acetylcholine, Animals, Drug Synergism, Evoked Potentials, Membranes, Neural Conduction, Norepinephrine, Parasympathomimetics, Receptors, Cholinergic, Synapses, Visual Cortex, Receptors, N-Methyl-D-Aspartate, Neurotransmitter Agents, Rats, In Vitro Techniques

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