The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus
Abstract
The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 microM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.
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“The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus (Blitzer et al., 1990; Burgard and Sarvey, 1990; Auerbach and Segal, 1994; Isaac et al., 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Blitzer et al., 1990
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Cites
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The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
Hampel, H., Mesulam, M.-M., Cuello, A. C., Farlow, M. R., Giacobini, E., Grossberg, G. T., Khachaturian, A. S., Vergallo, A., Cavedo, E., Snyder, P. J., et al. (2018) · Brain · doi:10.1093/brain/awy132 · Cited by 1,918
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733
Neuromodulation and cortical function: modeling the physiological basis of behavior
Hasselmo, M. E. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00113-t · Cited by 557
Hasselmo, M. E., & McGaughy, J. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45015-2 · Cited by 525
Hasselmo, M., & Schnell, E. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03898.1994 · Cited by 466
Metadata
- Authors
- Blitzer, R. D., Gil, O., & Landau, E. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- Mount Sinai Hospital (US)
- Corresponding author
- Blitzer, Robert D.
- ORCID
- Blitzer, Robert D.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1990-11
- Volume
- 119
- Issue
- 2
- Pages
- 207-210
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2071637530
- Cited by
- 192
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 8 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-02219, P50AG005138, 5-P50-AG05138-02, P01AG002219)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- long-term potentiation, cholinergic stimulation, carbachol, acetylcholine, hippocampal CA1, tetanic stimulation, presynaptic depression, postsynaptic mechanisms, memory
- MeSH terms
- Animals, Atropine, Carbachol, Electric Stimulation, Hippocampus, Male, Parasympathomimetics, Rats, Inbred Strains, Rats
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