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Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
Abstract
Apolipoprotein E-deficient mice provide a useful system for studying the role of apolipoprotein E (apoE) in the function of distinct neuronal systems. In the present study we focused on the cholinergic system of these mice. This was pursued by measurements of specific biochemical, physiological and cognitive parameters. Morris Water Maze tasks revealed impairments in working memory but not in reference memory of the apoE-deficient mice. Measurements of brain choline acetyltransferase activities revealed them to be markedly lower in the hippocampus and frontal cortex of the apoE-deficient mice than in the corresponding brain areas of the controls, but unaltered in other brain areas. In addition, hypothermia induced by the centrally acting muscarinic agonist, oxotremorine, was reduced in the apoE-deficient mice as compared to controls. These results show that apoE-deficient mice have cholinergic deficits and highlight the importance of this mouse model for studying the interactions between apoE and the cholinergic nervous system.
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Other studies show severe learning and memory deficits in apoE deficient mice.
“while others show severe learning and memory deficits (Gordon et al., 1995, Oitzl et al., 1997, Veinbergs et al., 1999)”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Gordon et al., 1995
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Metadata
- Authors
- Gordon, I., Grauer, E., Genis, I., Sehayek, E., & Michaelson, D. M.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 199
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0304-3940
- Cited by
- 172
- References
- 1
- Language
- en
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