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Cited by 117Sleep and Wakefulness ResearchNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Erasing Synapses in Sleep: Is It Time to Be SHY?

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Frank, Marcos Gabriel·2012·Neural Plasticity
DOI 10.1155/2012/264378PMC PMC3317003
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Abstract

Converging lines of evidence strongly support a role for sleep in brain plasticity. An elegant idea that may explain how sleep accomplishes this role is the “synaptic homeostasis hypothesis (SHY).” According to SHY, sleep promotes net synaptic weakening which offsets net synaptic strengthening that occurs during wakefulness. SHY is intuitively appealing because it relates the homeostatic regulation of sleep to an important function (synaptic plasticity). SHY has also received important experimental support from recent studies in Drosophila melanogaster. There remain, however, a number of unanswered questions about SHY. What is the cellular mechanism governing SHY? How does it fit with what we know about plasticity mechanisms in the brain? In this review, I discuss the evidence and theory of SHY in the context of what is known about Hebbian and non-Hebbian synaptic plasticity. I conclude that while SHY remains an elegant idea, the underlying mechanisms are mysterious and its functional significance unknown.

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  • It is most improbable that sleep need, to the extent this is determined by learning, is determined solely by Hebbian LTP or any other single form of synaptic plasticity.

    “itisthus most improbable that sleep need -to the extent this is determined by learning -is determined solely by Hebbian LTP (or any other single form of synaptic plasticity)”

    From About Sleep's Role in Memory (2013) · cites this paper as [410]

    Section 4.1 says it is improbable that learning-related sleep need is determined solely by Hebbian LTP or another single form of synaptic strengthening. The claim broadens that conclusion to any single form of synaptic plasticity, which the passage does not explicitly say. (LLM, conf=0.84)

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Authors
Frank, M. G.
Affiliations
University of Pennsylvania (US)
Corresponding author
Frank, Marcos Gabriel
ORCID
Frank, Marcos Gabriel
Venue
Neural Plasticity
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-15
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
DOI
10.1155/2012/264378
PMC
PMC3317003
OpenAlex
W2024812164
Cited by
117
References
23
Citations by year
2025: 9 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 15 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 20 · 2012: 4
FWCI
1.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Eye Institute (EY019022)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic homeostasis hypothesis, sleep, synaptic plasticity, Hebbian plasticity, Drosophila melanogaster, sleep homeostasis, neuroplasticity
MeSH terms
Animals, Brain, Drosophila melanogaster, Homeostasis, Humans, Learning, Neuronal Plasticity, Sleep, Synapses, Wakefulness, Mice, Rats

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