Cited by 149Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Inescapable stress enhances extracellular acetylcholine in the rat hippocampus and prefrontal cortex but not the nucleus accumbens or amygdala

Mark, G.P, Rada, P.V, Shors, T.J·1996·Neuroscience

DOI 10.1016/0306-4522(96)00211-4

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Abstract

A number of experimental results has pointed to a cholinergic involvement in the stress response. Recently, analytical techniques have become available to measure acetylcholine release in vivo during exposure to various stressors. In these experiments, microdialysis was used to monitor acetylcholine output every 15 min in the dorsal hippocampus, amygdala, nucleus accumbens and prefrontal cortex before, during and after 1 h of restraint, including a 15-min session of intermittent tail-shock (1/min, 1 mA, 1-s duration) in rats. In response to the stressful event, acetylcholine release was significantly increased in the prefrontal cortex (186%; p < 0.01) and hippocampus (168%; P < 0.01) but not in the amygdala or nucleus accumbens. The sole effects observed in the amygdala and nucleus accumbens occurred upon release from the restrainer, at which point acetylcholine levels were significantly elevated in both areas (amygdala: 150%; P < 0.05; nucleus accumbens: 13%; P < 0.05). An enhanced acetylcholine release was also evident during this sample period in the hippocampus and prefrontal cortex. These data demonstrate an enhancement of cholinergic activity in response to stress in two acetylcholine projection systems (hippocampus and prefrontal cortex) but not in the intrinsic acetylcholine system of the nucleus accumbens or the extrinsic innervation of the amygdala. Moreover, the data showed that relief from stress was accompanied by a more ubiquitous acetylcholine response that extended to each site tested.

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Authors: Mark, G. P., Rada, P. V., & Shors, T. J.
Affiliations: Princeton University (US)
Corresponding author: Mark, G.P
ORCID: Shors, T.J
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1996-08
Volume: 74
Issue: 3
Pages: 767-774
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(96)00211-4
OpenAlex: W2014948578
Cited by: 149
References: 64
Citations by year: 2025: 5 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 9 · 2014: 2 · 2013: 4 · 2012: 7
FWCI: 2.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: acetylcholine release, stress response, cholinergic system, hippocampus, prefrontal cortex, amygdala, nucleus accumbens, restraint stress, microdialysis, stress reduction
MeSH terms: Acetylcholine, Amygdala, Animals, Brain, Extracellular Space, Hippocampus, Male, Nucleus Accumbens, Organ Specificity, Restraint, Physical, Stress, Psychological, Time Factors, Rats, Sprague-Dawley, Prefrontal Cortex, Rats

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Inescapable stress enhances extracellular acetylcholine in the rat hippocampus and prefrontal cortex but not the nucleus accumbens or amygdala

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