Chronic stress disrupts neural coherence between cortico-limbic structures
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Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.
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Repeated and chronic stress may tax limbic systems that modulate arousal and approach behaviors, disrupt bottom-up and top-down connections, and potentially facilitate transition from ideation to behavior.
“Repeated and chronic stress may tax limbic systems that modulate arousal and approach behaviors, disrupt bottom-up and top-down connections, and potentially, facilitate the transition from ideation to behavior (32, 127).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [127]
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- Authors
- Oliveira, J. F., Dias, N. S., Correia, M., Gama-Pereira, F., Sardinha, V. M., Lima, A., Oliveira, A. F., Jacinto, L. R., Ferreira, D. S., Silva, A. M., Reis, J. S., Cerqueira, J. J., & Sousa, N.
- Affiliations
- University of Minho (PT)
- Universidade Politécnica do Cávado e do Ave (PT)
- Corresponding author
- Sousa, Nuno
- ORCID
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 10-10
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC3565161
- OpenAlex
- W2103621658
- Cited by
- 55
- References
- 46
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 2 · 2014: 2 · 2013: 4
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CiencIPCA (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission (273936)
- National Science Council
- Fundação Bial
- Fundação para a Ciência e a Tecnologia (COMPETE, PTDC/SAU-NSC/118194/2010, PTDC/SAU-ENB/118383/2010, FCOMP-01-0124-FEDER-022674, SFRH/BPD/66151/2009, SFRH/BD/40459/2007, FCOMP-01-0124-FEDER, /2009)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- chronic stress, cortico-limbic network, ventral hippocampus, medial prefrontal cortex, spectral coherence, chronic unpredictable mild stress, short-term stress, spatial reference memory, memory impairment
- MeSH terms
- Animals, Chronic Disease, Hippocampus, Limbic System, Male, Neural Pathways, Neuronal Plasticity, Stress, Psychological, Rats, Wistar, Prefrontal Cortex, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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