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Cited by 42Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal–prefrontal cortex pathway of rats in vivo: A possible involvement of monoaminergic systems

Lopes Aguiar, C., Romcy-Pereira, R. Neves, Escorsim Szawka, R., Galvis-Alonso, O. Yineth, Anselmo-Franci, J. Aparecida, Pereira Leite, J.·2008·Neuroscience
DOI 10.1016/j.neuroscience.2008.02.040
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Abstract

The prefrontal cortex is continuously required for working memory processing during wakefulness, but is particularly hypoactivated during sleep and in psychiatric disorders such as schizophrenia. Ammon's horn CA1 hippocampus subfield (CA1) afferents provide a functional modulatory path that is subjected to synaptic plasticity and a prominent monoaminergic influence. However, little is known about the muscarinic cholinergic effects on prefrontal synapses. Here, we investigated the effects of the muscarinic agonist, pilocarpine (PILO), on the induction and maintenance of CA1-medial prefrontal cortex (mPFC) long-term potentiation (LTP) as well as on brain monoamine levels. Field evoked responses were recorded in urethane-anesthetized rats during baseline (50 min) and after LTP (130 min), and compared with controls. LTP was induced 20 min after PILO administration (15 mg/kg, i.p.) or vehicle (NaCl 0.15 M, i.p.). In a separate group of animals, the hippocampus and mPFC were microdissected 20 min after PILO injection and used to quantify monoamine levels. Our results show that PILO potentiates the late-phase of mPFC LTP without affecting either post-tetanic potentiation or early LTP (20 min). This effect was correlated with a significant decrease in relative delta (1-4 Hz) power and an increase in sigma (10-15 Hz) and gamma (25-40 Hz) powers in CA1. Monoamine levels were specifically altered in the mPFC. We observed a decrease in dopamine, 5-HT, 5-hydroxyindolacetic acid and noradrenaline levels, with no changes in 3,4-hydroxyphenylacetic acid levels. Our data, therefore, suggest that muscarinic activation exerts a boosting effect on mPFC synaptic plasticity and possibly on mPFC-dependent memories, associated to monoaminergic changes.

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Crossref · 10.1016/j.neuroscience.2008.02.040

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  • This type of stimulation applied during early non-REM sleep specifically enhanced <1 Hz slow oscillations and additionally increased frontal slow spindle activity.

    “This type of stimulation applied during early non-REM sleep specifically enhanced Ͻ1 Hz slow oscillations and additionally increased frontal slow spindle activity (10)(11)(12).”

    From About Sleep's Role in Memory (2013) · cites this paper as [12]

  • Norepinephrine and acetylcholine are important for induction of late LTP and often synergistically enhance LTP and LTD.

    “Indeed, norepinephrine and acetylcholine are also important for the induction of late LTP (12,1295) and were often found to synergistically act to enhance LTP (140, 1309) as well as LTD (642).”

    From About Sleep's Role in Memory (2013) · cites this paper as [12]

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Authors
Lopes Aguiar, C., Romcy-Pereira, R. N., Escorsim Szawka, R., Galvis-Alonso, O. Y., Anselmo-Franci, J. A., & Pereira Leite, J.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Romcy-Pereira, R. Neves
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2008-06
Volume
153
Issue
4
Pages
1309-1319
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2008.02.040
OpenAlex
W2073884402
Cited by
42
References
87
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 8
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
muscarinic receptors, pilocarpine, long-term potentiation, late-phase LTP, hippocampus, medial prefrontal cortex, CA1, synaptic plasticity, monoamines, dopamine, serotonin, norepinephrine, 5-hydroxyindoleacetic acid, delta power, working memory, schizophrenia
MeSH terms
Acetylcholine, Analysis of Variance, Animals, Chromatography, High Pressure Liquid, Electric Stimulation, Electrochemistry, Electroencephalography, Hippocampus, Male, Neural Pathways, Synaptic Transmission, Pilocarpine, Spectrum Analysis, Time Factors, Biogenic Monoamines, Prefrontal Cortex, Long-Term Potentiation, Muscarinic Agonists, Rats, In Vitro Techniques

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