Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation
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Previously, we reported that bilateral excitotoxic lesions of the basolateral nucleus of the amygdala (BLA) block the enhancing effects of posttraining systemic or intrahippocampal glucocorticoid administration on memory for inhibitory avoidance training. The present study further examined the basis of this permissive influence of the BLA on hippocampal memory functioning. Immediate posttraining unilateral infusions of the specific glucocorticoid receptor agonist RU 28362 (11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-4,6-trien-20-yn-3-one; 3.0, 10.0, or 30.0 ng in 0.5 μl) administered into the dorsal hippocampus of male Sprague–Dawley rats induced dose-dependent enhancement of 48-h inhibitory avoidance retention. Infusions of the β-adrenoceptor antagonist atenolol (0.5 μg in 0.2 μl) into the ipsilateral, but not the contralateral, BLA 10 min prior to training blocked the hippocampal glucocorticoid effects on memory consolidation. Infusions of the muscarinic cholinergic antagonist atropine (0.5 μg in 0.2 μl) into either the ipsilateral or contralateral BLA before training did not block the hippocampal glucocorticoid effects. These findings provide further evidence that β-adrenergic activity in the BLA is essential in enabling glucocorticoid-induced modulation of memory consolidation and are consistent with the hypothesis that the BLA regulates the strength of memory consolidation in other brain structures. The ipsilateral nature of the BLA–hippocampus interaction indicates that BLA influences on hippocampal memory processes are mediated through neural pathways rather than by influences by means of the activation of peripheral stress responses.
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Activation of the amygdala exerts a facilitating effect on memory-related processing by other brain regions, including the hippocampus.
“Researchers outside of the stress-LTP field have long contended that activation of the amygdala exerts a facilitating effect on memory-related processing by other brain regions, including the hippocampus (McGaugh et al. [187]; Roozendaal et al. [188]; Nathan et al. [189]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Roozendaal et al. [188]
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- Authors
- Roozendaal, B., Nguyen, B. T., Power, A. E., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Roozendaal, Benno
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-09-28
- Volume
- 96
- Issue
- 20
- Pages
- 11642-11647
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC18087
- OpenAlex
- W1993475532
- Cited by
- 293
- References
- 4
- Citations by year
- 2026: 5 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 4 · 2018: 22 · 2017: 14 · 2016: 11 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 11
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Irvine
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- basolateral amygdala, hippocampus, memory consolidation, glucocorticoid receptor, RU 28362, beta-adrenergic activity, atenolol, noradrenergic modulation, passive avoidance, stress hormones, excitotoxic lesions
- MeSH terms
- Amygdala, Animals, Arousal, Atenolol, Dose-Response Relationship, Drug, Emotions, Hippocampus, Male, Memory, Norepinephrine, Receptors, Adrenergic, beta, Receptors, Glucocorticoid, Rats, Sprague-Dawley, Rats
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