Schizophrenic psychology, associative learning and the role of forebrain dopamine

Miller, Robert

doi:10.1016/0306-9877(76)90040-2

Cited by 67Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Schizophrenic psychology, associative learning and the role of forebrain dopamine

Miller, Robert·1976·Medical Hypotheses

DOI 10.1016/0306-9877(76)90040-2

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Abstract

It is suggested that schizophrenic thinking can be explained as a lowering of levels of significance for acceptance of conclusions based on inductive logic. The formal similarity between inductive logic and operant, or classical conditioning is pointed out. It is thus possible to explain the therapeutic effects of neuroleptic drugs by referring to the effect of these, and related drugs, and of lesions of ascending dopamine pathways, on acquisition of conditioned responses. It is tentatively suggested that recognition of association of related features of the environment, whether in humans or animals occurs in the basal ganglia by a dopamine dependent process. A role is suggested for neocortical noradrenaline in consolidaton of newly acquired associations. Implications and tests of this hypothesis are discussed.

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Perturbed dopamine transmission is related to psychosis through disrupted learning mechanisms, linking psychotic experiences to neurochemistry.
“relating perturbed dopamine transmission to psychosis via disrupted learning mechanisms, [12][13][14] thus linking psychotic experiences to neurochemistry.10”
From Computational psychiatry: a Rosetta Stone linking the brain to mental illness (2014) · cites this paper as [13]

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“Explanatory models inspired by dopamine's role in learning and motivation have been proposed to account for the positive symptoms of psychosis (Beninger 1988; Corlett et al. 2007; Gray 2004; Kapur 2003; Miller 1976).”
Background
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Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077716 · Cited by 227 · see citing works
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Authors: Miller, R.
Affiliations: University of Birmingham (GB)
Corresponding author: Miller, Robert
ORCID: Miller, Robert
Venue: Medical Hypotheses
Publisher: Elsevier BV
Published: 1976-09
Volume: 2
Issue: 5
Pages: 203-211
ISSN: 0306-9877 (ISSN-L)
DOI: 10.1016/0306-9877(76)90040-2
OpenAlex: W2061134309
Cited by: 67
References: 105
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 7
FWCI: 0.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Medical Hypotheses (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: schizophrenia, associative learning, dopamine, forebrain, inductive logic, operant conditioning, classical conditioning, antipsychotic drugs, conditioned response acquisition, basal ganglia, norepinephrine
MeSH terms: Animals, Association Learning, Basal Ganglia, Brain, Conditioning, Classical, Conditioning, Operant, Dopamine, Humans, Learning, Logic, Models, Theoretical, Schizophrenia, Schizophrenic Psychology, Thinking, Antipsychotic Agents

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Schizophrenic psychology, associative learning and the role of forebrain dopamine

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