Cited by 98Nicotinic Acetylcholine Receptors StudyPrenatal Substance Exposure EffectsSmoking Behavior and Cessation

Effect of maternal nicotine on the development of sites for [3H]nicotine binding in the fetal brain

Hagino, N., Lee, J.W.·1985·International Journal of Developmental Neuroscience

Abstract

The sites for [(3)H]nicotine binding in fetal brains were examined after administration of nicotine into pregnant rats. Administration of unlabelled nicotine into the pregnant rats increased Bmax values for the sites for [(3)H]nicotine binding without affecting Kd values in the fetal brains. Treatment with this regimen, however, did not show any significant change in the sites for [(3)H]quinuclidinyl benzylate (QNB) binding. In addition, treatment with this regimen increased Bmax values of the sites for [(3)H]nicotine binding in the brains of pregnant rats. α-Bungarotoxin had no effect on the sites for [(3)H]nicotine binding. It is inferred, therefore, that a similar response is elicited by nicotine binding sites to administered nicotine in both the fetal and maternal brains. Furthermore, a possible effect of nicotine in pregnant rats may be the facilitation of the development of nicotine acetylcholine receptors in the fetal brain.

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Crossref · 10.1016/0736-5748(85)90046-2

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8 of 8 references verified0 citation errors · 0 not checkable

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Authors
Hagino, N., & Lee, J. W.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
1985-01
Volume
3
Issue
5
Pages
567-571
ISSN
  • 0736-5748 (ISSN-L)
  • 1873-474X
OpenAlex
W2079743276
Cited by
98
References
8
Citations by year
2025: 1 · 2022: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
maternal nicotine exposure, fetal brain development, nicotinic acetylcholine receptors, alpha-bungarotoxin, pregnancy, prenatal nicotine exposure, receptor binding affinity

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