The DOI matches its Crossref record; 429 of the 429 references it cites were found in a registry or an index.
Health Consequences of Circadian Disruption in Humans and Animal Models
Abstract
Daily rhythms in behavior and physiology are programmed by a hierarchical collection of biological clocks located throughout the brain and body, known as the circadian system. Mounting evidence indicates that disruption of circadian regulation is associated with a wide variety of adverse health consequences, including increased risk for premature death, cancer, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive problems, mood disorders, and learning deficits. Here we review the evidence for the pervasive effects of circadian disruption in humans and animal models, drawing from both environmental and genetic studies, and identify questions for future research.
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“Circadian oscillations are ubiquitous in cells throughout the brain and body and their coordinated daily activity is essential for normal health1–3.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [2]
In the citing paper
“However, when circadian disruptions are chronic, as in shift work or frequent travel across time zones, long term physiological and neurological health deteriorate2, 5.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [2]
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The Circadian Clock and Human Health
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Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
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“Given the importance of circadian biology in regulating organismal health, it is of no surprise that the breakdown of daily circadian rhythms (see Glossary, Box 1) is a risk factor for a range of diseases, including metabolic syndrome, vascular disease and cancer (Anea et al., 2009; Bass and Takahashi, 2010; Evans and…”
BackgroundIkeno, T., & Yan, L. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416642065 · Cited by 37
Metadata
- Authors
- Evans, J. A., & Davidson, A. J.
- Affiliations
- Morehouse School of Medicine (US)
- Venue
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier
- Published
- 2013
- Volume
- 119
- Pages
- 283-323
- ISSN
- 1877-1173 (ISSN-L)
- OpenAlex
- W31275902
- Cited by
- 291
- References
- 429
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 23 · 2022: 29 · 2021: 24 · 2020: 44 · 2019: 26 · 2018: 28 · 2017: 19 · 2016: 22 · 2015: 31 · 2014: 13
- FWCI
- 13.94
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in molecular biology and translational science (publishedVersion)
- PubMed (publishedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- circadian rhythm disruption, circadian system, biological clock, health effects, cancer risk, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive disorders, mood disorders, learning deficits, premature mortality, genetic and environmental factors
- MeSH terms
- Animals, Circadian Rhythm, Humans, Models, Animal
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