Health Consequences of Circadian Disruption in Humans and Animal Models

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Zuckerman, A. J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.691-a · Cited by 8,766

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485

Adverse metabolic and cardiovascular consequences of circadian misalignment

Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351

Central and Peripheral Circadian Clocks in Mammals

Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166

Neurocognitive consequences of sleep deprivation

Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154

Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat

Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135

Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions

Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039

Molecular components of the mammalian circadian clock

Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,725

Mop3 is an essential component of the master circadian pacemaker in mammals.

Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621

The genetics of mammalian circadian order and disorder: implications for physiology and disease

Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525

Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage

Dodd, A. N., Salathia, N. S., Hall, A. J. W., Kevei, É., Tóth, R., Nagy, F., Hibberd, J. M., Millar, A. J., & Webb, A. A. R. (2005) · Science · doi:10.1126/science.1115581 · Cited by 1,489

Social jetlag and obesity

Roenneberg, T., Allebrandt, K. V., Merrow, M., & Vetter, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.038 · Cited by 1,407

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402

Positional Cloning of the Mouse Circadian Gene

King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,268

Health disorders of shift workers

Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218

Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188

Actions of Melatonin in the Reduction of Oxidative Stress

Reiter, R. J., Tan, D. X., Osuna, C., & Gitto, E. (2000) · Journal of Biomedical Science · doi:10.1007/bf02253360 · Cited by 1,182

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression

Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175

Circadian control of the immune system

Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059

Physiological significance of a peripheral tissue circadian clock

Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953

High Sensitivity of Human Melatonin, Alertness, Thermoregulation, and Heart Rate to Short Wavelength Light

Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., & Wirz-Justice, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0957 · Cited by 939

Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption

Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932

Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people

Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924

Peroxiredoxins are conserved markers of circadian rhythms

Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 905

Shift Work Sleep Disorder: Prevalence and Consequences Beyond that of Symptomatic Day Workers

Drake, C. L., Roehrs, T., Richardson, G., Walsh, J. K., & Roth, T. (2004) · Sleep · doi:10.1093/sleep/27.8.1453 · Cited by 860

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860

Night-Shift Work and Risk of Colorectal Cancer in the Nurses' Health Study

Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I. I., Fuchs, C. S., & Colditz, G. A. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.11.825 · Cited by 837

Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women

Pan, A., Schernhammer, E. S., Sun, Q., & Hu, F. B. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001141 · Cited by 805

Mania-like behavior induced by disruption of CLOCK

Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803

Light at night increases body mass by shifting the time of food intake

Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796

Shift work, safety and productivity

Folkard, S. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg047 · Cited by 774

A Mutation of the Circadian System in Golden Hamsters

Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 697

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Gibbs, J. E., Blaikley, J., Beesley, S., Matthews, L. C., Simpson, K. D., Boyce, S., Farrow, S. N., Else, K. J., Singh, D., Ray, D. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106750109 · Cited by 692

Shift work and chronic disease: the epidemiological evidence

Wang, X.-S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr001 · Cited by 670

System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658

Cytokine and Cytokine-Like Inflammation Markers, Endothelial Dysfunction, and Imbalanced Coagulation in Development of Diabetes and Its Complications

Goldberg, R. B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2534 · Cited by 650

Sleep loss and fatigue in shift work and shift work disorder

Åkerstedt, T., & Wright, K. P. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.03.001 · Cited by 639

Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632

Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation

Van Cauter, E. (1997) · Endocrine Reviews · doi:10.1210/er.18.5.716 · Cited by 608

Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance

Dijk, D., Duffy, J. F., & Czeisler, C. A. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00021.x · Cited by 602

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons

LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577

Dose-response relationships for resetting of human circadian clock by light

Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1996) · Nature · doi:10.1038/379540a0 · Cited by 559

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

Crawley, J. N., & Paylor, R. E. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1382 · Cited by 555

Disruption of circadian clocks has ramifications for metabolism, brain, and behavior

Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547

Strange vision: ganglion cells as circadian photoreceptors

Berson, D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00130-9 · Cited by 546

Dysregulation of inflammatory responses by chronic circadian disruption

Castanon-Cervantes, O., Wu, M., Ehlen, J. C., Paul, K., Gamble, K. L., Johnson, R. L., Besing, R. C., Menaker, M., Gewirtz, A. T., & Davidson, A. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001026 · Cited by 542

Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis

Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536

Depression scores associate with chronotype and social jetlag in a rural population

Levandovski, R., Dantas, G., Fernandes, L. C., Caumo, W., Torres, I., Roenneberg, T., Hidalgo, M. P. L., & Allebrandt, K. V. (2011) · Chronobiology International · doi:10.3109/07420528.2011.602445 · Cited by 527

Prospective study of shift work and risk of coronary heart disease in women

Kawachi, I., Colditz, G. A., Stampfer, M. J., Willett, W. C., Manson, J. E., Speizer, F. E., & Hennekens, C. H. (1995) · Circulation · doi:10.1161/01.cir.92.11.3178 · Cited by 524

PER3 polymorphism predicts sleep structure and waking performance

Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520

Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint

Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 514

Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation

Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499

PER2 controls lipid metabolism by direct regulation of PPARγ

Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T., & Sassone-Corsi, P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.10.005 · Cited by 489

Cocaine sensitization and reward are under the influence of circadian genes and rhythm

Abarca, C., Albrecht, U., & Spanagel, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142039099 · Cited by 472

Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms

Dijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467

Obesity in mice with adipocyte-specific deletion of clock component Arntl

Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465

Increased risk of ischaemic heart disease in shift workers

Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91619-3 · Cited by 459

Circadian Disruption Leads to Insulin Resistance and Obesity

Shi, S.-Q., Ansari, T. S., McGuinness, O. P., Wasserman, D. H., & Johnson, C. H. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.048 · Cited by 452

The circadian basis of winter depression

Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602425103 · Cited by 451

Masking: History, Definitions, and Measurement

Mrosovsky, N. (1999) · Chronobiology International · doi:10.3109/07420529908998717 · Cited by 449

Bright light effects on body temperature, alertness, EEG and behavior

Badia, P., Myers, B. L., Boecker, M. R., Culpepper, J., & Harsh, J. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90549-4 · Cited by 437

Deregulated expression of the PER1 , PER2 and PER3 genes in breast cancers

Chen, S., Choo, K., Hou, M., Yeh, K., Kuo, S., & Chang, J. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi075 · Cited by 435

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

Narasimamurthy, R., Hatori, M., Nayak, S. K., Liu, F., Panda, S., & Verma, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209965109 · Cited by 434

Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats

Blask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 431

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6

Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431

Chronic jet-lag increases mortality in aged mice

Davidson, A. J., Sellix, M. T., Daniel, J., Yamazaki, S., Menaker, M., & Block, G. D. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.058 · Cited by 427

Effects of Chronic Jet Lag on Tumor Progression in Mice

Filipski, E., Delaunay, F., King, V. M., Wu, M., Claustrat, B., Gréchez‐Cassiau, A., Guettier, C., Hastings, M. H., & Lévi, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0674 · Cited by 424

Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood

Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 418

Host Circadian Clock as a Control Point in Tumor Progression

Filipski, E. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.9.690 · Cited by 413

Shift work, sleep, and sleepiness – differences between shift schedules and systems

Sallinen, M., & Kecklund, G. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2900 · Cited by 412

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes

Woon, P. Y., Kaisaki, P. J., Bragança, J., Bihoreau, M., Lévy, J., Farrall, M., & Gauguier, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703247104 · Cited by 410

Constant light desynchronizes mammalian clock neurons

Ohta, H., Yamazaki, S., & McMahon, D. G. (2005) · Nature Neuroscience · doi:10.1038/nn1395 · Cited by 405

Prospective Cohort Study of the Risk of Prostate Cancer among Rotating-Shift Workers: Findings from the Japan Collaborative Cohort Study

Kubo, T., Ozasa, K., Mikami, K., Wakai, K., Fujino, Y., Watanabe, Y., Miki, T., Nakao, M., Hayashi, K., Suzuki, K. A. O., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj232 · Cited by 403

Rotating shift work and the metabolic syndrome: a prospective study

De Bacquer, D., Van Risseghem, M., Clays, E., Kittel, F., De Backer, G., & Braeckman, L. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyn360 · Cited by 394

CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

Andrews, J. L., Zhang, X., McCarthy, J. J., McDearmon, E. L., Hornberger, T. A., Russell, B., Campbell, K. S., Arbogast, S., Reid, M. B., Walker, J. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014523107 · Cited by 389

A Time to Work: Recent Trends in Shift Work and Flexible Schedules

McMenamin, T. M. (2007) · Monthly labor review · Cited by 389

Circadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy

Miller, B. H., Olson, S. L., Turek, F. W., Levine, J. E., Horton, T. H., & Takahashi, J. S. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.055 · Cited by 377

The Adaptive Value of Circadian Clocks

Woelfle, M. A., Ouyang, Y., Phanvijhitsiri, K., & Johnson, C. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.023 · Cited by 375

The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse

Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08138.2000 · Cited by 367

Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain?

Guilding, C., & Piggins, H. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05581.x · Cited by 356

Genetic Control of Melatonin Synthesis in the Pineal Gland of the Mouse

Ebihara, S., Marks, T. N., Hudson, D. J., & Menaker, M. (1986) · Science · doi:10.1126/science.3941912 · Cited by 354

Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation

Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025231 · Cited by 353

Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber.

Aschoff, J., Hoffmann, K. H., Pohl, H. H., & Wever, R. A. (1975) · PubMed · Cited by 352

Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes

Oishi, K., Miyazaki, K., Kadota, K., Kikuno, R. F., Nagase, T., Atsumi, G.-I., Ohkura, N., Azama, T., Mesaki, M., Yukimasa, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304564200 · Cited by 349

Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man

SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 347

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

Di Lorenzo, L., De Pergola, G., Zocchetti, C., L'Abbate, N., Basso, A., Pannacciulli, N., Cignarelli, M., Giorgino, R., & Soleo, L. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802419 · Cited by 346

Light-at-night, circadian disruption and breast cancer: assessment of existing evidence

Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345

Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase

Lo, J. C., Groeger, J. A., Santhi, N., Arbon, E. L., Lazar, A. S., Hasan, S., von Schantz, M., Archer, S. N., & Dijk, D.-J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045987 · Cited by 342

Sleep and Cardiovascular Disease

Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 340

Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription

Spengler, M. L., Kuropatwinski, K. K., Comas, M., Gasparian, A. V., Fedtsova, N. G., Gleiberman, A. S., Gitlin, I. I., Artemicheva, N. M., Deluca, K. A., Gudkov, A. V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206274109 · Cited by 338

Night Shift Work and the Risk of Endometrial Cancer

Viswanathan, A. N., Hankinson, S. E., & Schernhammer, E. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2485 · Cited by 338

Do Permanent Night Workers Show Circadian Adjustment? A Review Based on the Endogenous Melatonin Rhythm

Folkard, S. (2008) · Chronobiology International · doi:10.1080/07420520802106835 · Cited by 335

Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits

Cho, K. (2001) · Nature Neuroscience · doi:10.1038/88384 · Cited by 332

Differential Effects of Permanent and Rotating Shifts on Self-Report Sleep Length: A Meta-Analytic Review

Pilcher, J. J., Lambert, B. J., & Huffcutt, A. I. (2000) · SLEEP · doi:10.1093/sleep/23.2.1b · Cited by 324

Shift Work and Metabolic Syndrome: Respective Impacts of Job Strain, Physical Activity, and Dietary Rhythms

Esquirol, Y., Bongard, V., Mabile, L., Jonnier, B., Soulat, J., & Perret, B. (2009) · Chronobiology International · doi:10.1080/07420520902821176 · Cited by 324

Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work

Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323

Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters

Martino, T. A., Oudit, G. Y., Herzenberg, A. M., Tata, N., Koletar, M. M., Kabir, G. M., Belsham, D. D., Backx, P. H., Ralph, M. R., & Sole, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00829.2007 · Cited by 317

Metabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study

Karlsson, B. H., Knutsson, A., Lindahl, B., & Alfredsson, L. S. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-003-0440-y · Cited by 316

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

Sadacca, L. A., Lamia, K. A., deLemos, A. S., Blum, B., & Weitz, C. J. (2011) · Diabetologia · doi:10.1007/s00125-010-1920-8 · Cited by 314

Circadian Systems: Longevity as a Function of Circadian Resonance in Drosophila melanogaster

Pittendrigh, C. S., & Minis, D. H. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1537 · Cited by 303

Vascular Disease in Mice With a Dysfunctional Circadian Clock

Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 298

Rotating Night Shift Work and the Risk of Ischemic Stroke

Brown, D. L., Feskanich, D., Sanchez, B. N., Rexrode, K. M., Schernhammer, E. S., & Lisabeth, L. D. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp056 · Cited by 297

Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals

Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 289

The Circadian Clock Protein BMAL1 Is Necessary for Fertility and Proper Testosterone Production in Mice

Alvarez, J. D., Hansen, A. G., Ord, T. S., Bębas, P., Chappell, P. E., Giebultowicz, J. M., Williams, C. J., Moss, S., & Sehgal, A. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730407311254 · Cited by 287

Time-of-day-dependent effects of bright light exposure on human psychophysiology: comparison of daytime and nighttime exposure

Rüger, M., Gordijn, M. C. M., Beersma, D. G. M., de Vries, B., & Daan, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00121.2005 · Cited by 286

Gastrointestinal disorders among shift workers

Knutsson, A., & Bøggild, H. (2010) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.2897 · Cited by 286

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286

Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation

Altimus, C. M., Güler, A. D., Villa, K. L., McNeill, D. S., LeGates, T. A., & Hattar, S. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808312105 · Cited by 286

A prospective study of fatal occupational accidents – relationship to sleeping difficulties and occupational factors

Åkerstedt, T., Fredlund, P., Gillberg, M., & Jansson, B. (2002) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2002.00287.x · Cited by 285

Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei

de la, H. O., Iglesia, Meyer, J. L., Carpino, A., & Schwartz, W. J. (2000) · Science · doi:10.1126/science.290.5492.799 · Cited by 285

Shiftwork and Metabolic Risk Factors of Cardiovascular Disease

Ha, M., & Park, J. (2005) · Journal of Occupational Health · doi:10.1539/joh.47.89 · Cited by 276

The Significance of Circadian Organization for Longevity in the Golden Hamster

Hurd, M. W., & Ralph, M. R. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000255 · Cited by 275

Molecular clock is involved in predictive circadian adjustment of renal function

Zuber, A. M., Centeno, G., Pradervand, S., Nikolaeva, S., Maquelin, L., Cardinaux, L., Bonny, O., & Firsov, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904890106 · Cited by 274

An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center

Nagano, M., Adachi, A. A., Nakahama, K., Nakamura, T., Tamada, M., Meyer-Bernstein, E. L., Sehgal, A., & Shigeyoshi, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-14-06141.2003 · Cited by 273

Phase relations between a circadian rhythm and its zeitgeber within the range of entrainment

Aschoff, J., & Pohl, H. H. (1978) · Die Naturwissenschaften · doi:10.1007/bf00440545 · Cited by 269

Clock Gene Expression in the Murine Gastrointestinal Tract: Endogenous Rhythmicity and Effects of a Feeding Regimen

Hoogerwerf, W. A., Hellmich, H. L., Cornélissen, G., Franz Halberg, A., Shahinian, V. B., Bostwick, J., Savidge, T., & Cassone, V. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.009 · Cited by 268

The role of mPer2 clock gene in glucocorticoid and feeding rhythms

Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263

A longitudinal study on the effect of shift work on weight gain in male Japanese workers.

Suwazono, Y., Dochi, M., Sakata, K., Okubo, Y., Oishi, M., Tanaka, K., Kobayashi, E., Kido, T., & Nogawa, K. (2008) · Obesity · doi:10.1038/oby.2008.298 · Cited by 259

Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork

Barclay, J. L., Husse, J., Bode, B., Naujokat, N., Meyer-Kovac, J., Schmid, S. M., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037150 · Cited by 259

Light Affects Morning Salivary Cortisol in Humans

Scheer, F. A. J. L., & Buijs, R. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.6102 · Cited by 258

Light-induced suppression of endogenous circadian amplitude in humans

Jewett, M. E., Kronauer, R. E., & Czeisler, C. A. (1991) · Nature · doi:10.1038/350059a0 · Cited by 253

Circadian misalignment in major depressive disorder

Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.009 · Cited by 253

Shift work and disturbed sleep/wakefulness

Åkerstedt, T. (1998) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(98)90004-1 · Cited by 252

Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior

Mukherjee, S., Coque, L., Cao, J., Kumar, J., Chakravarty, S., Asaithamby, A., Graham, A., Gordon, E., Enwright, J. F., Dileone, R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.031 · Cited by 249

An analysis of the “eveningness–morningness” dimension in “depressive” college students

Chelminski, I., Ferraro, F. R., Petros, T. V., & Plaud, J. J. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00051-2 · Cited by 243

Impaired Cued and Contextual Memory in NPAS2-Deficient Mice

Garcia, J. A., Zhang, D., Estill, S. J., Michnoff, C. H., Rutter, J. P., Reick, M., Scott, K., Diaz-Arrastia, R. R., & McKnight, S. L. (2000) · Science · doi:10.1126/science.288.5474.2226 · Cited by 242

Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function

Viswambharan, H., Carvas, J. M., Antic, V., Marecic, A., Jud, C., Zaugg, C. E., Ming, X., Montani, J., Albrecht, U., & Yang, Z. (2007) · Circulation · doi:10.1161/circulationaha.106.653303 · Cited by 242

Shift work and cancer – considerations on rationale, mechanisms, and epidemiology

Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241

Chronic Jet Lag Produces Cognitive Deficits

Cho, K., Ennaceur, A., Cole, J. C., & Suh, C. K. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-06-j0005.2000 · Cited by 239

Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work

Crowley, S. J., Lee, C., Tseng, C. Y., Fogg, L. F., & Eastman, C. I. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403258422 · Cited by 238

Forced Desynchronization of Dual Circadian Oscillators within the Rat Suprachiasmatic Nucleus

de la Iglesia, H. O., Cambras, T., Schwartz, W. J., & Dı́ez-Noguera, A. (2004) · Current Biology · doi:10.1016/j.cub.2004.04.034 · Cited by 236

Hippocampal-dependent learning requires a functional circadian system

Ruby, N. F., Hwang, C. E., Wessells, C., Fernandez, F., Zhang, P., Sapolsky, R., & Heller, H. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808259105 · Cited by 234

Effects of circadian disruption on the cardiometabolic system

Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232

The Circadian ClockPeriod 2Gene Regulates Gamma Interferon Production of NK Cells in Host Response to Lipopolysaccharide-Induced Endotoxic Shock

Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., & Sun, Z. S. (2006) · Infection and Immunity · doi:10.1128/iai.00287-06 · Cited by 231

The clock gene Per2 links the circadian system to the estrogen receptor

Gery, S., Virk, R. K., Chumakov, K., Yu, A., & Koeffler, H. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210585 · Cited by 227

The Impact of Rotating Shift Work on the Prevalence of Irritable Bowel Syndrome in Nurses

Nojkov, B., Rubenstein, J. H., Chey, W. D., & Hoogerwerf, W. A. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.48 · Cited by 226

Rotating Shift Work and Risk of Prostate Cancer

Conlon, M., Lightfoot, N., & Kreiger, N. (2006) · Epidemiology · doi:10.1097/01.ede.0000249519.33978.31 · Cited by 225

A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers

Fujino, Y., Iso, H., Tamakoshi, A., Inaba, Y., Koizumi, A., Kubo, T., & Yoshimura, T. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj185 · Cited by 225

Differential Resynchronisation of Circadian Clock Gene Expression within the Suprachiasmatic Nuclei of Mice Subjected to Experimental Jet Lag

Reddy, A. B., Field, M. D., Maywood, E. S., & Hastings, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07326.2002 · Cited by 224

Shiftwork and Cardiovascular Disease: Review of Disease Mechanisms

Knutsson, A., & Bøggild, H. (2000) · Reviews on Environmental Health · doi:10.1515/reveh.2000.15.4.359 · Cited by 221

Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

Wang, T. A., Yu, Y. V., Govindaiah, G., Ye, X., Artinian, L. R., Coleman, T. P., Sweedler, J. V., Cox, C. L., & Gillette, M. U. (2012) · Science · doi:10.1126/science.1222826 · Cited by 221

Duration of shiftwork related to body mass index and waist to hip ratio

van Amelsvoort, L., Schouten, E., & Kok, F. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801028 · Cited by 221

Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease

Penev, P. D., Kolker, D. E., Zee, P. C., & Turek, F. W. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.6.h2334 · Cited by 216

The impact of the circadian timing system on cardiovascular and metabolic function

Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215

The effects of depression and age on the Horne-Ostberg morningness-eveningness score

Drennan, M. D., Klauber, M. R., Kripke, D. F., & Goyette, L. M. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90096-b · Cited by 215

Entrainment of the human circadian pacemaker to longer-than-24-h days

Gronfier, C., Wright, K. P., Kronauer, R. E., & Czeisler, C. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702835104 · Cited by 215

Metabolic Syndrome in Permanent Night Workers

Biggi, N., Consonni, D., Galluzzo, V., Sogliani, M., & Costa, G. (2008) · Chronobiology International · doi:10.1080/07420520802114193 · Cited by 213

Circadian and wakefulness-sleep modulation of cognition in humans

Wright, K. P., Lowry, C. A., & LeBourgeois, M. K. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00050 · Cited by 209

Shift Work, Jet Lag, and Female Reproduction

Mahoney, M. M. (2010) · International Journal of Endocrinology · doi:10.1155/2010/813764 · Cited by 209

Influence of light at night on murine anxiety- and depressive-like responses

Fonken, L. K., Finy, M. S., Walton, J. C., Weil, Z. M., Workman, J. L., Ross, J., & Nelson, R. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.001 · Cited by 209

Shift Work at Young Age Is Associated with Elevated Long-Term Cortisol Levels and Body Mass Index

Manenschijn, L., van Kruysbergen, R., de Jong, F. H., Koper, J. W., & van Rossum, E. F. C. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1551 · Cited by 209

Shiftwork and myocardial infarction: a case-control study.

Knutsson, A., Hallquist, J., Reuterwall, C., Theorell, T., & Åkerstedt, T. (1999) · Occupational and Environmental Medicine · doi:10.1136/oem.56.1.46 · Cited by 208

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

Wang, L. M.-C., Dragich, J. M., Kudo, T., Odom, I. H., Welsh, D. K., O’Dell, T. J., & Colwell, C. S. (2009) · ASN NEURO · doi:10.1042/an20090020 · Cited by 208

Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus

Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207

Postprandial hormone and metabolic responses amongst shift workers in Antarctica

Lund, J., Arendt, J., Hampton, S., English, J., & Morgan, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710557 · Cited by 206

Circadian Phase Variation in Bipolar I Disorder

Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2005) · Chronobiology International · doi:10.1081/cbi-200062413 · Cited by 204

Cellular Circadian Clocks in Mood Disorders

McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203

Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent

Fonken, L. K., Kitsmiller, E., Smale, L., & Nelson, R. J. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412448324 · Cited by 203

Effects of light and food schedules on liver and tumor molecular clocks in mice

Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji083 · Cited by 200

The Problem: Shiftwork

Costa, G. (1997) · Chronobiology International · doi:10.3109/07420529709001147 · Cited by 199

Loss of cryptochrome reduces cancer risk in p53 mutant mice

Öztürk, N., Lee, J. H., Gaddameedhi, S., & Sancar, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813028106 · Cited by 199

Visual impairment and circadiam rhythm disorders

Lockley, S. W., Arendt, J., & Skene, D. J. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/slockley · Cited by 198

CLOCK in Breast Tumorigenesis: Genetic, Epigenetic, and Transcriptional Profiling Analyses

Hoffman, A. E., Yi, C., Zheng, T., Stevens, R. G., Leaderer, D., Zhang, Y., Holford, T. R., Hansen, J., Paulson, J., & Zhu, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3798 · Cited by 197

Experimental ‘Jet Lag’ Inhibits Adult Neurogenesis and Produces Long-Term Cognitive Deficits in Female Hamsters

Gibson, E. M., Wang, C., Tjho, S., Khattar, N., & Kriegsfeld, L. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015267 · Cited by 196

Effect of shift work on body mass index and metabolic parameters

Morikawa, Y., Nakagawa, H., Miura, K., Soyama, Y., Ishizaki, M., Kido, T., Naruse, Y., Suwazono, Y., & Nogawa, K. (2007) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.1063 · Cited by 194

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

Dubrovsky, Y. V., Samsa, W. E., & Kondratov, R. V. (2010) · Aging · doi:10.18632/aging.100241 · Cited by 193

Sleep and wakefulness out of phase with internal biological time impairs learning in humans

Wright, K. P., Hull, J. T., Hughes, R. J., Ronda, J. M., & Czeisler, C. A. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.4.508 · Cited by 191

Chronic exposure to dim light at night suppresses immune responses in Siberian hamsters

Bedrosian, T. A., Fonken, L. K., Walton, J. C., & Nelson, R. J. (2011) · Biology Letters · doi:10.1098/rsbl.2010.1108 · Cited by 190

Temporal dynamics of mouse hippocampal clock gene expression support memory processing

Jilg, A., Lesny, S., Peruzki, N., Schwegler, H., Selbach, O., Dehghani, F., & Stehle, J. H. (2009) · Hippocampus · doi:10.1002/hipo.20637 · Cited by 190

The Circadian Clock Interacts with Metabolic Physiology to Influence Reproductive Fitness

Xu, K., DiAngelo, J. R., Hughes, M. E., Hogenesch, J. B., & Sehgal, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.001 · Cited by 187

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

Wood, P. A., Yang, X., Taber, A., Oh, E.-Y., Ansell, C. M., Ayers, S. E., Al-Assaad, Z., Carnevale, K. A., Berger, F. G., Peña, M. M. O., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0196 · Cited by 186

Prematurity and work in pregnancy.

McDonald, A. D., McDonald, J. C., Armstrong, B., Cherry, N., Nolin, A. D., & Robert, D. (1988) · Occupational and Environmental Medicine · doi:10.1136/oem.45.1.56 · Cited by 185

Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer

Gauger, M. A., & Sancar, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1119 · Cited by 185

Measurement of, and Some Reasons for, Differences in Eating Habits Between Night and Day Workers

Waterhouse, J. M., Buckley, P., Edwards, B., & Reilly, T. P. (2003) · Chronobiology International · doi:10.1081/cbi-120025536 · Cited by 182

Rotating Shift Work and Menstrual Cycle Characteristics

Lawson, C. C., Whelan, E. A., Hibert, E. N. L., Spiegelman, D. L., Schernhammer, E. S., & Rich-Edwards, J. W. (2011) · Epidemiology · doi:10.1097/ede.0b013e3182130016 · Cited by 180

Periaqueductal gray matter projections to midline and intralaminar thalamic nuclei of the rat

Krout, K. E., & Loewy, A. D. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000814)424:1 · Cited by 180

Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway

Monje, F. J., Cabatic, M., Divisch, I., Kim, E.-J., Herkner, K. R., Binder, B. R., & Pollak, D. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1537-11.2011 · Cited by 178

Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: Further evidence for circadian misalignment in non-seasonal depression

Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.027 · Cited by 177

EFFECTS OF SHIFTWORK ON SLEEP AND MENSTRUAL FUNCTION IN NURSES

Labyak, S. E., Lava, S., Turek, F. W., & Zee, P. C. (2002) · Health Care For Women International · doi:10.1080/07399330290107449 · Cited by 177

Developmental and reproductive performance in circadian mutant mice

Dolatshad, H., Campbell, E. A., O’Hara, L., Maywood, E. S., Hastings, M. H., & Johnson, M. H. (2005) · Human Reproduction · doi:10.1093/humrep/dei313 · Cited by 176

Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-α

Hashiramoto, A., Yamane, T., Tsumiyama, K., Yoshida, K., Komai, K., Yamada, H., Yamazaki, F., Doi, M., Okamura, H., & Shiozawa, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903284 · Cited by 174

Replicable differences in preferred circadian phase between bipolar disorder patients and control individuals

Wood, J. A., Birmaher, B. B., Axelson, D., Ehmann, M., Kalas, C., Monk, K., Turkin, S. R., Kupfer, D. J., Brent, D. A., Monk, T. H., et al. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.03.003 · Cited by 174

Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women

Zhu, Y. L., Brown, H. N., Zhang, Y., Stevens, R. G., & Zheng, T. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.268.14.1 · Cited by 173

Revised Limit Cycle Oscillator Model of Human Circadian Pacemaker

Jewett, M. E., Forger, D. B., & Kronauer, R. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873049901400608 · Cited by 171

Light and Diurnal Cycle Affect Human Heart Rate: Possible Role for the Circadian Pacemaker

Scheer, F. A. J. L., van Doornen, L. J. P., & Buijs, R. M. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000614 · Cited by 170

Shift Work, Nitrous Oxide Exposure and Subfertility among Swedish Midwives

Ahlborg, G., Axelsson, G., & Bodin, L. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.4.783 · Cited by 168

Circadian Gene Expression Regulates Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretory Patterns in the Hypothalamic GnRH-Secreting GT1-7 Cell Line

Chappell, P. E., White, R. S., & Mellon, P. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11202.2003 · Cited by 168

Dim light at night provokes depression-like behaviors and reduces CA1 dendritic spine density in female hamsters

Bedrosian, T. A., Fonken, L. K., Walton, J. C., Haim, A., & Nelson, R. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.01.004 · Cited by 167

Chronic Shift-Lag Alters the Circadian Clock of NK Cells and Promotes Lung Cancer Growth in Rats

Logan, R. W., Zhang, C., Murugan, S., O’Connell, S., Levitt, D., Rosenwasser, A. M., & Sarkar, D. K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102715 · Cited by 166

Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm

Yang, X., Wood, P. A., Oh, E.-Y., Du‐Quiton, J., Ansell, C. M., & Hrushesky, W. J. M. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0133-z · Cited by 165

Impaired Steroidogenesis and Implantation Failure in Bmal1−/− Mice

Ratajczak, C. K., Boehle, K. L., & Muglia, L. J. (2008) · Endocrinology · doi:10.1210/en.2008-1021 · Cited by 162

Shift work at young age is associated with increased risk for multiple sclerosis

Hedström, A. K., Åkerstedt, T., Hillert, J. A., Olsson, T. P., & Alfredsson, L. S. (2011) · Annals of Neurology · doi:10.1002/ana.22597 · Cited by 161

The Circadian Clock and Human Health

Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004

Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease

Musiek, E. S., Xiong, D. D., & Holtzman, D. M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.121 · Cited by 529

Animal models of major depression and their clinical implications

Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375

Circadian dysfunction induces leptin resistance in mice

Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260

Endocrine Effects of Circadian Disruption

Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170

Biological Rhythms and Medicine: Cellular, Metabolic, Physiopathologic, and Pharmacologic Aspects

Reinberg, A., & Smolensky, M. H. (2011) · Cited by 74

[Research progress of circadian rhythm].

Wang, J., Hou, W.-T., Qin, X., et al. (2021) · PubMed · doi:10.19540/j.cnki.cjcmm.20210308.601 · Cited by 2

Interactions between the circadian clock and metabolism: there are good times and bad times

Shi, M., & Zheng, X. (2012) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms110 · Cited by 22

Circadian rhythms in the aged: a review

Casale, G., & de Nicola, P. (1984) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(84)90028-1 · Cited by 31

Keeping time in the dark: Potato diel and circadian rhythmic gene expression reveals tissue‐specific circadian clocks

Hoopes, G. M., Zarka, D. G., Feke, A., Acheson, K., Hamilton, J. P., Douches, D. S., Buell, C. R., & Farré, E. M. (2022) · Plant Direct · doi:10.1002/pld3.425 · Cited by 15