Circadian Disruption in Psychiatric Disorders

Jones, Stephanie G.; Benca, Ruth M.

doi:10.1016/j.jsmc.2015.07.004

Cited by 86Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

Circadian Disruption in Psychiatric Disorders

Jones, Stephanie G., Benca, Ruth M.·2015·Sleep Medicine Clinics

DOI 10.1016/j.jsmc.2015.07.004

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Abstract

Evidence suggests that abnormalities in circadian rhythms might prove causally or pathophysiologically significant in psychiatric illness. The circadian regulation of hormonal and behavioral timekeeping processes is often altered in patients with major depression, bipolar disorder, and schizophrenia, and a susceptibility to rhythm instability may contribute to the functional impairment. For some patients, interventions that stabilize or resynchronize circadian rhythms prove therapeutically effective. Circadian disruption in the clinical profiles of most psychiatric illnesses and the treatment efficacy of chronobiological interventions suggest that attention to circadian phenotypes in a range of psychiatric disorders may help to uncover shared pathophysiologic mechanisms.

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It remains unknown whether the relationship reflects causation in which circadian disruptions predispose individuals to developing mood disorders, causation in which the manifestation of mood disorder leads to circadian disruption, or an absence of causation in which the association reflects commonalities in underlying physiological processes.
“Thus, it remains unknown whether the relationship reflects: (1) causation in which circadian disruptions predisposes individuals to developing mood disorders, (2) causation in which the manifestation of mood disorder leads to circadian disruption, or (3) an absence of causation in which the association between circadian disruption and mood disorders reflects commonalities in underlying”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [177]

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Circadian rhythm disruption and mental health
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Chronotype and circadian rhythm in bipolar disorder: A systematic review
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Sleep Predicts Collegiate Academic Performance
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Association between affective temperaments and mood features in bipolar disorder II: the role of insomnia and chronobiological rhythms desynchronization
Palagini, L., Miniati, M., Caruso, D., Massa, L., Novi, M., Pardini, F., Salarpi, G., Pini, S., Marazziti, D., Etain, B., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.134 · Cited by 20 · see citing works

Authors: Jones, S. G., & Benca, R. M.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Jones, Stephanie G.
ORCID: Jones, Stephanie G.
Benca, Ruth M.
Venue: Sleep Medicine Clinics
Publisher: Elsevier BV
Published: 2015-12
Volume: 10
Issue: 4
Pages: 481-493
ISSN: 1556-407X (ISSN-L)
DOI: 10.1016/j.jsmc.2015.07.004
OpenAlex: W2135711186
Cited by: 86
References: 102
Citations by year: 2026: 6 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 7
FWCI: 0.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine Clinics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian rhythm, circadian rhythm disruption, mental illness, major depressive disorder, bipolar disorder, schizophrenia, circadian phenotype, pathophysiology
MeSH terms: Animals, Mental Disorders, Circadian Rhythm, Humans

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Circadian Disruption in Psychiatric Disorders

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