Suprachiasmatic nucleus
Abstract
The suprachiasmatic nucleus (SCN), the master circadian clock of mammals, is composed of multiple circadian oscillator neurons. Most of them exhibit significant circadian rhythms in their clock gene expression and spontaneous firing when cultured in dispersed cells, as well as in an organotypic slice. The distribution of periods depends on the SCN tissue organization, suggesting that cell-to-cell interaction is important for synchronization of the constituent oscillator cells. This cell-to-cell interaction involves both synaptic interactions and humoral mediators. Cellular oscillators form at least three separate but mutually coupled regional pacemakers, and two of them are involved in the photoperiodic regulation of behavioral rhythms in mice. Coupling of cellular oscillators in the SCN tissue compensates for the dysfunction due to clock gene mutations, on the one hand, and desynchronization within and between the regional pacemakers that suppresses the coherent rhythm expression from the SCN, on the other hand. The multioscillator pacemaker structure of the SCN is advantageous for responding to a wide range of environmental challenges without losing coherent rhythm outputs.
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Direct nocturnal light exposure suppresses melatonin production and resets the timing of the circadian clock.
“Direct nocturnal light exposure suppresses melatonin production41 and resets the timing of the circadian clock.33,42,43”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [41]
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- Authors
- Honma, S., Ono, D., Suzuki, Y., Inagaki, N., Yoshikawa, T., Nakamura, W., & Honma, K.-I.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Honma, Sato
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2012
- Volume
- 199
- Pages
- 129-141
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W9035763
- Cited by
- 59
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 3
- FWCI
- 6.62
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22659047, 22590220, 21390064, 24791401)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- suprachiasmatic nucleus, circadian clock, clock gene expression, oscillator synchronization, cell coupling, photoperiodic regulation, behavioral rhythms, desynchronization, synaptic interactions, humoral factors
- MeSH terms
- Animals, Cell Communication, Circadian Rhythm, Humans, Nerve Net, Suprachiasmatic Nucleus, Mice, Circadian Rhythm Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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