Cited by 59Circadian rhythm and melatoninNonlinear Dynamics and Pattern FormationSleep and Wakefulness Research

Suprachiasmatic nucleus

Honma, Sato, Ono, Daisuke, Suzuki, Yohko, Inagaki, Natsuko, Yoshikawa, Tomoko, Nakamura, Wataru, Honma, Ken-ichi·2012·Progress in brain research

Abstract

The suprachiasmatic nucleus (SCN), the master circadian clock of mammals, is composed of multiple circadian oscillator neurons. Most of them exhibit significant circadian rhythms in their clock gene expression and spontaneous firing when cultured in dispersed cells, as well as in an organotypic slice. The distribution of periods depends on the SCN tissue organization, suggesting that cell-to-cell interaction is important for synchronization of the constituent oscillator cells. This cell-to-cell interaction involves both synaptic interactions and humoral mediators. Cellular oscillators form at least three separate but mutually coupled regional pacemakers, and two of them are involved in the photoperiodic regulation of behavioral rhythms in mice. Coupling of cellular oscillators in the SCN tissue compensates for the dysfunction due to clock gene mutations, on the one hand, and desynchronization within and between the regional pacemakers that suppresses the coherent rhythm expression from the SCN, on the other hand. The multioscillator pacemaker structure of the SCN is advantageous for responding to a wide range of environmental challenges without losing coherent rhythm outputs.

Integrity signals

Registry

Crossref · 10.1016/b978-0-444-59427-3.00029-0

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Honma, S., Ono, D., Suzuki, Y., Inagaki, N., Yoshikawa, T., Nakamura, W., & Honma, K.-I.
Affiliations
Hokkaido University (JP)
Corresponding author
Honma, Sato
Venue
Progress in brain research
Publisher
Elsevier
Published
2012
Volume
199
Pages
129-141
ISSN
0079-6123 (ISSN-L)
OpenAlex
W9035763
Cited by
59
References
33
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 3
FWCI
6.62
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (22659047, 22590220, 21390064, 24791401)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
suprachiasmatic nucleus, circadian clock, clock gene expression, oscillator synchronization, cell coupling, photoperiodic regulation, behavioral rhythms, desynchronization, synaptic interactions, humoral factors
MeSH terms
Animals, Cell Communication, Circadian Rhythm, Humans, Nerve Net, Suprachiasmatic Nucleus, Mice, Circadian Rhythm Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review