The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Folate receptor endocytosis and trafficking
Abstract
Folate absorption is primarily mediated by a membrane transporter with micro-molar affinities for folates. Paradoxically, folates are only present at low nanomolar concentrations in extracellular milieus; membrane folate receptors (FRs) with nanomolar affinities for folates are likely to substantially modulate folate availability for these transporters. Functional isoforms of FRs are anchored to the membrane by a glycolipid anchor, the glycosylphosphatidylinositol (GPI) anchor. In this chapter we discuss recent insights that have been obtained with regards to GPI-anchored protein trafficking in the context of folate transport via the GPI-anchored FR. Specifically, we focus on recent advances in elucidating the pathways and mechanisms of endocytic sorting of the GPI-anchored FR, and the connection with membrane rafts.
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“FA was employed as the main targeting ligand, which is known for its binding potential to folate receptors, which are over-expressed on many cancers and facilitate the endocytosis pathway [26,34,35,36].”
From Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles (2020) · cites this paper as [35]
Citations
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Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
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Sorted by citations
Sahay, G., Alakhova, D. Y., & Kabanov, A. V. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.01.036 · Cited by 2,181
Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599
Clathrin-independent pathways of endocytosis
Mayor, S., Parton, R. G., & Donaldson, J. G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016758 · Cited by 525
Koźmiński, P., Halik, P. K., Chesori, R., & Gniazdowska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103483 · Cited by 326
Micelles structure development as a strategy to improve smart cancer therapy
Hanafy, N., El-Kemary, M., & Leporatti, S. (2018) · Cancers · doi:10.3390/cancers10070238 · Cited by 287
AbouAitah, K., Hassan, H. A., Swiderska-Sroda, A., Gohar, L., Shaker, O. G., Wojnarowicz, J., Opalinska, A., Smalc-Koziorowska, J., Gierlotka, S., & Lojkowski, W. (2020) · Cancers · doi:10.3390/cancers12010144 · Cited by 105
Phan, Q. T., Le, M. H., Le, T. T. H., Tran, T. H. H., Xuan, P. N., & Ha, P. T. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.003 · Cited by 68
McCarty, M. (2015) · Healthcare · doi:10.3390/healthcare3020233 · Cited by 23
Metadata
- Authors
- Sabharanjak, S.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2004-04-29
- Volume
- 56
- Issue
- 8
- Pages
- 1099-1109
- ISSN
- 0169-409X
- Cited by
- 273
- References
- 1
- Language
- en
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