Micelles structure development as a strategy to improve smart cancer therapy

Hanafy, Nemany; El-Kemary, Maged; Leporatti, Stefano

doi:10.3390/cancers10070238

Cited by 289Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsNanoplatforms for cancer theranostics

Micelles structure development as a strategy to improve smart cancer therapy

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Hanafy, Nemany, El-Kemary, Maged, Leporatti, Stefano·2018·Cancers

DOI 10.3390/cancers10070238PMC PMC6071246

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Abstract

Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more block copolymers, or by using fatty acid molecules that can modify themselves in a rounded shape. Recently, hybrid and responsive stimuli nanomicelles are formed either by integration with metal nanoparticles such as silver, gold, iron oxide nanoparticles inside micelles or by a combination of lipids and polymers into single composite. Herein, through this special issue, an updated overview of micelles development and their application for cancer therapy will be discussed.

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SAXS experiments are extensively applied to investigate the structure of polymeric micelles in solution, empty or loaded with drugs, providing detailed description of their size, shape and inner architecture on the 1-100 nm length-scale.
“SAXS experiments are extensively applied to investigate the structure of polymeric micelles in solution, empty or loaded with drugs, providing detailed description of their size, shape and inner architecture on the 1-100 nm length-scale [191,192].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [192]
Section 1.2 (Micelles Structure) says micelle structures have been studied with several experimental techniques, including X-ray diffraction, but does not identify SAXS or describe what SAXS reveals. Section 1.1 gives typical micelle diameters of 5–100 nm, and Section 5 discusses drug-loaded micelles; neither supports the claimed 1–100 nm SAXS measurement range or its characterization of empty and drug-loaded micelles. (LLM, conf=0.78)
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[73]Kabanov A.V. Alakhov V.Y. Micelles of amphilphilic block copolymers as vehicles for drug delivery Amphiphilic Block Copolymers: Self-Assembly and Applications Alexandridis P. Lindman B. Elsevier Amsterdam, The Netherlands 2000 347 376

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Authors: Hanafy, N., El-Kemary, M., & Leporatti, S.
Affiliations: Kafrelsheikh University (EG)
Istituto di Nanotecnologia (IT)
Corresponding author: Leporatti, Stefano
ORCID: Hanafy, Nemany
El-Kemary, Maged
Leporatti, Stefano
Venue: Cancers
Publisher: MDPI AG
Published: 2018-07-20
Volume: 10
Issue: 7
Pages: 238
ISSN: 2072-6694 (ISSN-L)
DOI: 10.3390/cancers10070238
PMC: PMC6071246
OpenAlex: W2884808176
Cited by: 287
References: 112
Citations by year: 2026: 15 · 2025: 31 · 2024: 60 · 2023: 37 · 2022: 52 · 2021: 45 · 2020: 32 · 2019: 12 · 2018: 3
FWCI: 1.54
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cancers (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Research Executive Agency (PITN-GA-2012-316549 (IT LIVER))
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: micelles, cancer therapy, drug delivery, block copolymers, self-assembly, metal nanoparticles, drug stability, local drug delivery

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