Globular Adiponectin Activates Motility and Regenerative Traits of Muscle Satellite Cells
Open accessAbstract
Regeneration of adult injured skeletal muscle is due to activation of satellite cells, a population of stem cells resident beneath the basal lamina. Thus, information on soluble factors affecting satellite cell activation, as well as migration towards injury and fusion into new myofibers are essential. Here, we show that globular adiponectin (gAd), positively affects several features of muscle satellite cells. gAd activates satellite cells to exit quiescence and increases their recruitment towards myotubes. gAd elicits in satellite cells a specific motility program, involving activation of the small GTPase Rac1, as well as expression of Snail and Twist transcription factors driving a proteolytic motility, useful to reach the site of injury. We show that satellite cells produce autocrine full length adiponectin (fAd), which is converted to gAd by activated macrophages. In turns, gAd concurs to attract to the site of injury both satellite cells and macrophages and induces myogenesis in muscle satellite cells. Thus, these findings add a further role for gAd in skeletal muscle, including the hormone among factors participating in muscle regeneration.
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gApN elicits a specific motility program in satellite cells by allowing them to produce specific metalloproteases, which can degrade the extracellular matrix surrounding muscle fibers, thus driving a proteolytic migration to reach the injury site.
“gApN also elicits a specific motility program in satellite cells by allowing them to produce specific metalloproteases, which can degrade the extracellular matrix surrounding muscle fibers, thus driving a proteolytic migration to reach the injury site [68].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [68]
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- Authors
- Fiaschi, T., Giannoni, E., Taddei, M. L., & Chiarugi, P.
- Affiliations
- University of Florence (IT)
- Corresponding author
- Chiarugi, Paola
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-05-18
- Volume
- 7
- Issue
- 5
- Pages
- e34782
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3356356
- OpenAlex
- W1970945669
- Cited by
- 37
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- globular adiponectin, satellite cells, skeletal muscle regeneration, satellite cell activation, cell motility, Rac1, snails, Twist, myogenesis, macrophages, myofiber fusion
- MeSH terms
- Snail Family Transcription Factors, Animals, Cell Movement, Cells, Cultured, Macrophage Activation, Phosphorylation, Regeneration, Transcription Factors, Wound Healing, Muscle Fibers, Skeletal, rac1 GTP-Binding Protein, Satellite Cells, Skeletal Muscle, p38 Mitogen-Activated Protein Kinases, Mice, Twist-Related Protein 1, Adiponectin
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