Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicity
Abstract
Sleep disturbance is one of the most prominent complaints of alcohol-dependent patients. In view of recent evidence that the immune system is integrated with other homeostatic processes ultimately regulated by the brain, the influence of sleep on host defense mechanisms and the expression of proinflammatory and T helper cell cytokines deserves attention in alcohol dependence. Although not all immune alterations found in alcohol-dependent persons are related to disordered sleep, it is exceedingly important to know whether sleep influences immunity in alcoholism because of the recognized impact of disordered sleep on infectious disease risk. Conversely, feedback systems are also operating between the brain and the immune system, and abnormalities in the expression of cytokines might contribute to sleep disturbances in alcohol-dependent persons. In this review, we identify the immune alterations found in association with alcohol dependence and discuss the implications of these findings for infectious disease risk, with particular attention to the interaction between African-American ethnicity and alcoholism in contributing to this risk. We provide evidence that sleep disruption occurs in association with alcohol dependence and that African-American alcohol-dependent persons show greater abnormalities in sleep and sleep regulatory processes than shown by Euro-American alcohol-dependent persons. The relations among alcoholism, sleep, and immunity are discussed, with an emphasis on understanding how the cytokine network is altered during sleep in the African-American alcohol-dependent populations. The potential is to use cytokine agonists or antagonists to determine whether physiologic changes in cytokines have a role in the homeostatic regulation of sleep in human beings, which has tremendous implications for the development of novel treatments of alcohol-related sleep disorders.
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Following sleep deprivation in the first night half, TNF production in monocytes and TNF mRNA are increased in the morning.
“Following sleep deprivation in the first night half, TNF production in monocytes and TNF mRNA were shown to be increased in the morning (256, 262, 264).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [262]
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
“Plasma levels of TNF were mostly unchanged during or on the day after acute sleep deprivation/restriction in healthy humans (224, 261, 334, 480, 489, 506).”
BackgroundInflammatory Markers and Sleep Disturbance in Major Depression
Motivala, S. J., Sarfatti, A., Olmos, L., & Irwin, M. R. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000149259.72488.09 · Cited by 286 · see citing works
Self-citationSleep and Inflammation: Psychoneuroimmunology in the Context of Cardiovascular Disease
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Alcoholism and inflammation: Neuroimmunology of behavioral and mood disorders
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Irwin, M., Rinetti, G., Redwine, L., Motivala, S., Dang, J., & Ehlers, C. (2004) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.02.001 · Cited by 95 · see citing works
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Sleep depth and fatigue: Role of cellular inflammatory activation
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Relationship between trait-anger and sleep disturbances in middle-aged men and women
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Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep
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Neuro-inflammatory Response and Immune–Brain Crosstalk in Sleep Regulation
Jha, P. K., & Bouâouda, H. (2024) · Progress in inflammation research · doi:10.1007/978-3-031-74744-1_5 · Cited by 1 · see citing works
Sleep and Immune Correlates: Translational Research in Clinical Populations
Motivala, S. J., & Irwin, M. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-69146-6_10
Self-citationInnate and Cell-Mediated Immunity
Dhabhar, F. S. (2007)
- Authors
- Irwin, M. R., & Rinetti, G.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Irwin, Michael R.
- ORCID
- Irwin, Michael R.
- Venue
- Alcohol
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 32
- Issue
- 1
- Pages
- 53-61
- ISSN
- 0741-8329 (ISSN-L)
- OpenAlex
- W2072158235
- Cited by
- 13
- References
- 102
- Citations by year
- 2024: 1 · 2019: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01aa010215-02)
- National Institute on Alcohol Abuse and Alcoholism (AA13239, AA10215, R01AA013239)
- National Institute on Aging (AG18267)
- National Institute of Mental Health (MH-55253, R01MH055253, T32MH019925, T32 MH 19925)
- National Institute on Drug Abuse (R01DA016541, DA 16541)
- National Center for Research Resources ((M01 RR00865), M01RR000865)
- NIH Clinical Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- alcoholism, sleep disorders, immune function, African American ethnicity, inflammatory cytokines, T helper cells, neuroimmune interactions, infectious disease risk, sleep regulation
- MeSH terms
- Alcoholism, Black or African American, Humans, Sleep Wake Disorders, Cytokines
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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