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Cited by 23Sleep and Wakefulness ResearchCircadian rhythm and melatoninTryptophan and brain disorders

Systemic immune parameters and sleep after ultra-low dose administration of IL-2 in healthy men

Lange, Tanja, Marshall, Lisa, Späth-Schwalbe, Ernst, Fehm, Horst-Lorenz, Born, Jan·2002·Brain, Behavior, and Immunity
DOI 10.1016/s0889-1591(02)00018-1
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Abstract

A somnogenic function is suspected for various cytokines. Foregoing experiments in humans indicated a selective increase in the production of interleukin-2 (IL-2) during sleep as compared with nocturnal wakefulness. Here, we examined whether conversely, IL-2 exerts a promoting influence on sleep. Also, the effects of IL-2 administered at ultra-low doses on systemic immune and endocrine parameters were assessed. Eighteen healthy men participated in three night sessions, receiving subcutaneously at 19:00 h either placebo or recombinant human IL-2 at doses of 1000 and 10,000 IU/kg bw. Polysomnographical recordings were obtained between 23:00 and 07:00 h. Blood was collected repeatedly to determine (i) white blood cell (WBC) counts including the enumeration of monocytes, natural killer (NK) cells, and lymphocyte subsets, (ii) serum concentrations of IL-2, soluble IL-2 receptor (sIL-2r), IL-4, IL-6, and interferon-gamma (IFN-gamma), and (iii) concentrations of adrenocorticotropin (ACTH), cortisol, thyreotropin (TSH), and growth hormone (GH). Changes after 1000 IU/kg bw IL-2 generally remained non-significant. However, distinct effects occurred after 10,000 IU/kg bw IL-2, inducing serum IL-2 concentrations selectively activating the high affinity IL-2 receptor. At this dose, IL-2 reduced the number of circulating lymphocytes (including all major subtypes) and NK cells, while counts of monocytes and neutrophils were increased. IL-4 release was stimulated and IFN-gamma concentration reduced after IL-2. Also, IL-2 increased the TSH concentration. There were no hints at a sleep promoting effect of IL-2. Immune changes suggest that nocturnal IL-2 administration induces a shift towards Th2 mediated defense.

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  • Administration of IFN-α or IL-2 in healthy participants did not change PSG-derived sleep parameters the following night.

    “Administration of IFN-α (520) or IL-2 (324) in healthy participants did not change PSG-derived sleep parameters the following night.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [324]

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Authors
Lange, T., Marshall, L., Späth-Schwalbe, E., Fehm, H.-L., & Born, J.
Affiliations
University of Lübeck (DE)
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2002-12
Volume
16
Issue
6
Pages
663-674
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/s0889-1591(02)00018-1
OpenAlex
W1991976124
Cited by
23
References
56
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
interleukin-2, sleep promotion, cytokines, sleep-wake cycle, lymphocyte subsets, natural killer cells, monocytes, soluble interleukin-2 receptor, Th2 immune response, ACTH, thyroid-stimulating hormone, growth hormone, cortisol, IL-4, interferon-gamma
MeSH terms
Adrenocorticotropic Hormone, Adult, Blood Pressure, Body Temperature, Double-Blind Method, Heart Rate, Humans, Hydrocortisone, Injections, Subcutaneous, Interferon-gamma, Interleukin-2, Leukocyte Count, Male, Platelet Count, Sleep, Solubility, Neuroimmunomodulation, Receptors, Interleukin-2, Interleukin-4, Interleukin-6, Cross-Over Studies, Analgesics, Non-Narcotic, Human Growth Hormone

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