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Cited by 95Sleep and Wakefulness ResearchSleep and related disordersSleep and Work-Related Fatigue

Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics

Irwin, Michael, Rinetti, Gina, Redwine, Laura, Motivala, Sarosh, Dang, Jeff, Ehlers, Cindy·2004·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2004.02.001
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Abstract

Animal studies reveal that cytokines play a key role in the regulation of sleep. Alcoholic patients show profound alterations of sleep and a defect in the homeostatic recovery of sleep following sleep loss. In this study, we investigated whether nocturnal plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF) were associated with disordered sleep in alcohol dependence by testing the temporal relationships between these inflammatory cytokines and sleep, before and after sleep deprivation. All-night polysomnography and serial blood sampling at 23:00, 03:00, and 06:30 h were conducted across baseline, partial sleep deprivation, and recovery nights in abstinent African American alcoholics (n=16) and matched controls (n=15). Coupled with prolonged sleep latency and increased rapid eye movement sleep, alcoholics showed nocturnal elevations of IL-6 and TNF as compared to controls after adjustment for alcohol consumption and body mass index. Following sleep deprivation, alcoholics showed greater nocturnal levels of IL-6 and greater nocturnal increases of TNF as compared to controls. Pre-sleep IL-6 levels at 23:00 h correlated with prolonged sleep latency after adjustment for potential confounders whereas IL-6 levels at 03:00 h correlated with rapid eye movement sleep in the second half of the night. Taken together, these findings indicate that circulating levels of proinflammatory cytokines may have a negative influence on sleep initiation. These findings have implications for determining why sleep is disordered in alcoholics and may aid in the development of novel treatments to optimize sleep in this population.

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  • For abstinent alcohol-dependent patients with ongoing sleep continuity problems, one night of sleep loss raises IL-6 and TNF, unlike in those without such sleep issues.

    “in abstinent alcohol-dependent patients who report ongoing disturbances of sleep continuity, a single night of sleep loss triggers increase in IL-6 and TNF, which is not found in those who have no underlying sleep problems (Irwin et al, 2004).”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Irwin et al, 2004

  • People with chronic sleep disturbance may be more vulnerable to inflammation after an episode of sleep loss.

    “among those with chronic sleep disturbance, there appears to be an increased vulnerability to inflammation following a bout of sleep loss.”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Irwin et al, 2004

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Research works printed but not linked: 2

  1. Tan, 1982, Sampling distributions and robustness of t, F, and variance-ratio in two samples and ANOVA models with respect to departure from normality, Commun. Stat.—Theory Methods, 11, 485
  2. Zautra, A.J., Yocum, D., Villanueva, I., Smith, B., Davis, M., Irwin, M., in press. Immune responses to depression and stressful events of female rheumatoid arthritis patients. J. Rheumatol.

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Authors
Irwin, M., Rinetti, G., Redwine, L., Motivala, S., Dang, J., & Ehlers, C.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Irwin, Michael
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2004-07
Volume
18
Issue
4
Pages
349-360
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2004.02.001
OpenAlex
W2024392891
Semantic Scholar
a53e3c5abe1e742fafc479e0d9b9e5256531f92f
Cited by
95
References
57
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 10
FWCI
3.51
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag018367-05, 5r01aa013239-06, 5r01aa010215-02)
  • National Institute on Alcohol Abuse and Alcoholism (AA13239, AA10215)
  • National Institute on Aging (AG 18367)
  • National Institute of Mental Health (MH-55253, R01MH055253, T32MH019925, T32 MH 19925)
  • National Institute on Drug Abuse (R01DA016541, DA 16541)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR/AG41867)
  • National Center for Research Resources ((M01 RR00865), M01RR000865)
  • NIH Clinical Center
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
alcoholism, sleep disorders, inflammatory cytokines, interleukin-6, TNF-α, sleep deprivation, sleep latency, REM sleep, sleep homeostasis
MeSH terms
Adult, Alcoholism, Analysis of Variance, Black or African American, Circadian Rhythm, Electroencephalography, Humans, Male, Reference Values, Sleep Deprivation, Sleep Wake Disorders, Sleep Stages, Temperance, Tumor Necrosis Factor-alpha, Interleukin-6, Polysomnography

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