Cited by 152Alcohol Consumption and Health EffectsImmune Response and InflammationImmunotoxicology and immune responses

Exposure-dependent effects of ethanol on the innate immune system

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Goral, Joanna, Karavitis, John, Kovacs, Elizabeth J.·2008·Alcohol

Abstract

Extensive evidence indicates that ethanol (alcohol) has immunomodulatory properties. Many of its effects on innate immune response are dose dependent, with acute or moderate use associated with attenuated inflammatory responses, and heavy ethanol consumption linked with augmentation of inflammation. Ethanol may modify innate immunity via functional alterations of the cells of the innate immune system. Mounting evidence indicates that ethanol can diversely affect antigen recognition and intracellular signaling events, which include activation of mitogen activated protein kinases, and NFkappaB, mediated by Toll-like receptors, leading to altered inflammatory responses. The mechanism(s) underlying these changes may involve dose-dependent effects of ethanol on the fluidity of cell membrane, resulting in interference with the timely assembly or disassembly of lipid rafts. Ethanol could also modify cell activation by specific interactions with cell membrane molecules.

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Crossref · 10.1016/j.alcohol.2008.02.003

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Authors
Goral, J., Karavitis, J., & Kovacs, E. J.
Affiliations
Loyola University Medical Center (US)
Corresponding author
Kovacs, Elizabeth J.
Venue
Alcohol
Publisher
Elsevier BV
Published
2008-06
Volume
42
Issue
4
Pages
237-247
ISSN
0741-8329 (ISSN-L)
OpenAlex
W2076165862
Cited by
152
References
142
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 18 · 2012: 18
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Alcohol (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (F31AA017027, T32AA013527, R01AA012034)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
ethanol, innate immunity, immunomodulation, inflammation, Toll-like receptors, NF-κB, MAPK signaling, lipid rafts, membrane fluidity, dose-dependent effects, heavy alcohol consumption, antigen recognition
MeSH terms
Alcohol Drinking, Ethanol, Animals, Dose-Response Relationship, Drug, Humans, Immunity, Innate, Immunologic Factors, Inflammation, Membrane Fluidity, Phagocytes, Phagocytosis, Signal Transduction, Inflammation Mediators, Membrane Microdomains, Toll-Like Receptors

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