Cited by 639Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

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Development of the gut microbiota in infancy and its impact on health in later life

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Tanaka, Masaru, Nakayama, Jiro·2017·Allergology International

DOI 10.1016/j.alit.2017.07.010

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Abstract

Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.

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Background
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Background
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Background
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Authors: Tanaka, M., & Nakayama, J.
Affiliations: Kyushu University (JP)
Corresponding author: Nakayama, Jiro
ORCID: Tanaka, Masaru
Nakayama, Jiro
Venue: Allergology International
Publisher: Elsevier BV
Published: 2017-10
Volume: 66
Issue: 4
Pages: 515-522
ISSN: 1323-8930 (ISSN-L)
DOI: 10.1016/j.alit.2017.07.010
OpenAlex: W2746392566
Cited by: 639
References: 130
Citations by year: 2026: 41 · 2025: 69 · 2024: 72 · 2023: 75 · 2022: 99 · 2021: 101 · 2020: 92 · 2019: 62 · 2018: 25 · 2017: 3
FWCI: 4.62
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Allergology International (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Japan Society for the Promotion of Science (17H04620, 25304006)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, infancy, microbial colonization, immune system development, allergic diseases, environmental factors, long-term health, digestive tract development, host-microbe interactions
MeSH terms: Gastrointestinal Microbiome, Age Factors, Animals, Anti-Bacterial Agents, Disease Susceptibility, Food, Health Status, Humans, Hypersensitivity, Immune System, Infant, Infant, Newborn, Milk, Human, Delivery, Obstetric, Biodiversity, Host-Pathogen Interactions, Microbiota

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Development of the gut microbiota in infancy and its impact on health in later life

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