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Development of the gut microbiota in infancy and its impact on health in later life
Open accessAbstract
Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.
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“As described in the introduction it is the first three years of life that diet, together with other factors, appears to have the greatest impact on microbial ecology [11].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [11]
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Kaczmarczyk, M., Löber, U., Adamek, K., Węgrzyn, D., Skonieczna‐Żydecka, K., Malinowski, D., Łoniewski, I., Markó, L., Ulas, T., Forslund, S. K., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02839-w · Cited by 72
Lozovaya, N., Nardou, R., Tyzio, R., Chiesa, M., Pons-Bennaceur, A., Eftekhari, S., Bui, T.-T., Billon-Grand, M., Rasero, J., Bonifazi, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45635-9 · Cited by 68
Ahn, J.-W., Lee, S., Kim, B., Nam, M. H., Ahn, Y. G., Park, Y. M., Jeong, S., Park, M. J., Song, K. B., Lee, S., et al. (2021) · Pediatric Allergy and Immunology · doi:10.1111/pai.13678 · Cited by 68
Tazi, A., Plainvert, C., Anselem, O., Ballon, M., Marcou, V., Seco, A., Alaoui, F. E., Joubrel, C., Helali, N. E., Falloukh, E., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz033 · Cited by 67
Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota
Huang, J., Zhang, J., Wang, X., Jin, Z., Zhang, P., Su, H., & Sun, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.821900 · Cited by 74
“The gut microbiota protects the host from allergic reactions by acting on both intrinsic and adaptive immunity (65).”
BackgroundLee, M.-J., Park, Y. M., Kim, B., Tae, I. H., Kim, N.-E., Pranata, M., Kim, T., Won, S., Kang, N. J., Lee, D., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2068366 · Cited by 68
“The Th1/Th2 balance is essential for immune regulation, and an imbalance Th1/Th2 can lead to chronic inflammation and allergic diseases.(11) Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, and its course is affected by the microbiome.”
BackgroundWicaksono, W. A., Cernava, T., Wassermann, B., Abdelfattah, A., Soto-Girón, M. J., Toledo, G. V., Virtanen, S. M., Knip, M., Hyöty, H., & Berg, G. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2258565 · Cited by 70
“Microbiome assembly starts during birth, and babies acquire their first microbiota inoculum from their mother and other humans as well as the local environment.(2,3) The development of the gut microbiota during early life depends on breast-feeding and environmental exposures and is critical for immune system developme…”
Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity
McKeen, S., Young, W., Mullaney, J. A., Fraser, K., McNabb, W. C., & Roy, N. C. (2019) · Nutrients · doi:10.3390/nu11020364 · Cited by 66
Mucosal immunity to poliovirus
Connor, R. I., Brickley, E. B., Wieland‐Alter, W., Ackerman, M. E., Weiner, J. A., Modlin, J. F., Bandyopadhyay, A. S., & Wright, P. F. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00428-0 · Cited by 67
Revealing the importance of prenatal gut microbiome in offspring neurodevelopment in humans
Sun, Z., Lee‐Sarwar, K. A., Kelly, R. S., Lasky-Su, J. A., Litonjua, A. A., Weiss, S. T., & Liu, Y. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104491 · Cited by 69
“…the gut microbiota in the fi rst years of life, a healthy breastfeeding infant should have a microbial community that is distinct from an adult composition, 45,46 which is mainly determined by environmental exposures 47 such as delivery mode, breast (versus formula) feeding, and antibiotics.”
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review
Krausová, M., Braun, D., Buerki-Thurnherr, T., Gundacker, C., Schernhammer, E., Wisgrill, L., & Warth, B. (2023) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051922-113350 · Cited by 61
Human milk microbiota associated with early colonization of the neonatal gut in Mexican newborns
Corona-Cervantes, K., García‐González, I., Villalobos-Flores, L. E., Hernández-Quiroz, F., Piña-Escobedo, A., Hoyo‐Vadillo, C., Rangel-Calvillo, M. N., & Garcı́a-Mena, J. (2020) · PeerJ · doi:10.7717/peerj.9205 · Cited by 62
Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis
Mihi, B., & Good, M. L. (2018) · Clinics in Perinatology · doi:10.1016/j.clp.2018.09.007 · Cited by 62
Utilizing the fecal microbiota to understand foal gut transitions from birth to weaning
Torre, U. D. L., Henderson, J., Furtado, K. L., Pedroja, M., Elenamarie, O., Mora, A., Pechanec, M. Y., Maga, E. A., & Mienaltowski, M. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216211 · Cited by 64
“Greater levels of Enterobacteriaceae at Day 7 are likely the result of exposure of the foal to the mare’s feces and copraphagic events affecting the foal’s microbiota [26, 27].”
BackgroundJin, G., Tang, Q., Ma, J., Liu, X., Zhou, B., Sun, Y., Pang, X., Guo, Z., Xie, R., Liu, T., et al. (2021) · mSystems · doi:10.1128/msystems.01337-20 · Cited by 62
Psoriasis: Interplay between dysbiosis and host immune system
Kapoor, B., Gulati, M., Rani, P., & Gupta, R. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103169 · Cited by 62
Dynamic construction of gut microbiota may influence allergic diseases of infants in Southwest China
Shen, X. P., Wang, M., Zhang, X., He, M., Li, M., Cheng, G., Wan, C., & He, F. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1489-4 · Cited by 61
Examining the Complex Relationship Between Tuberculosis and Other Infectious Diseases in Children
Whittaker, E., López‐Varela, E., Broderick, C. M., & Seddon, J. A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00233 · Cited by 63
“Following weaning, the adult pattern is seen with Bacteroides, Prevotella, Ruminococcus, Clostridium, andVeillonella occupying the gut (203).”
BackgroundThe potential of outdoor environments to supply beneficial butyrate-producing bacteria to humans
Brame, J. E., Liddicoat, C., Abbott, C. A., & Breed, M. F. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146063 · Cited by 60
Song, E., & Shin, J. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2209.09050 · Cited by 66
“The first three years of life have a great impact on the development of the gut microbiota, and gut microbial diversity increases with age until it becomes stable in adulthood [38].”
BackgroundDarnaud, M., Vadder, F. D., Bogeat, P., Boucinha, L., Bulteau, A., Bunescu, A., Couturier, C., Delgado, A., Dugua, H., Elie, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26963-9 · Cited by 56
“result from parasitic infections, immunodeficiencies or long-lived IgE producing plasma cells 341 generated by food antigens in mice with low-diversity microbiota during early life [47, 52, 53].”
BackgroundBabies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life
Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 60
Bacterial analysis in the early developmental stages of the black tiger shrimp (Penaeus monodon)
Angthong, P., Uengwetwanit, T., Arayamethakorn, S., Chaitongsakul, P., Karoonuthaisiri, N., & Rungrassamee, W. (2020) · Scientific Reports · doi:10.1038/s41598-020-61559-1 · Cited by 58
Breast milk: more than just nutrition!
Nuzzi, G., Trambusti, I., Cicco, M. D., & Peroni, D. G. (2021) · Minerva Pediatrics · doi:10.23736/s2724-5276.21.06223-x · Cited by 57
Risk Factors for Gut Dysbiosis in Early Life
Parkin, K., Christophersen, C. T., Verhasselt, V., Cooper, M. N., & Martino, D. (2021) · Microorganisms · doi:10.3390/microorganisms9102066 · Cited by 64
“However, evidence suggests initial colonisation of the GIT may begin as early as in utero [16] from species detected in the infant gut during the second trimester [17], with the mature, stable form of the gut microbiome being established at around three years of age [18].”
BackgroundCantorna, M. T., Lin, Y., Arora, J., Bora, S. A., Tian, Y., Nichols, R. G., & Patterson, A. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01772 · Cited by 59
“Microbial exposure following birth is critical for immune development and alterations in the gut microbiota during development can have negative effects for allergy and other immune mediated diseases later in life (39).”
BackgroundA Review on Probiotic Microencapsulation and Recent Advances of their Application in Bakery Products
Arepally, D., Reddy, R. S., Goswami, T. K., & Coorey, R. (2022) · Food and Bioprocess Technology · doi:10.1007/s11947-022-02796-2 · Cited by 55
“Accordingly, human microbiota is the entire collection of microorganisms that is hosted by a person, this could be at least 1014 microbes, which is equivalent to 1–2 kg of the total body weight and is more than the number of cells in the body (Tanaka & Nakayama, 2017; D’Argenio et al., 2015).”
BackgroundMucus, Microbiomes and Pulmonary Disease
Meldrum, O. W., & Chotirmall, S. H. (2021) · Biomedicines · doi:10.3390/biomedicines9060675 · Cited by 57
“Only a few bacterial species contain a sufficient repertoire of genomic-encoded catabolic glycosidic enzymes to disassemble complex mucin glycans as a carbon source, highlighting the existence of a cross-feeding cabal, akin to the role of microbiota in the gastrointestinal tract [61,62].”
BackgroundLittlejohn, P. T., & Finlay, B. B. (2021) · BMC Medicine · doi:10.1186/s12916-021-01910-z · Cited by 53
Can we modulate the breastfed infant gut microbiota through maternal diet?
Sindi, A. S., Geddes, D. T., Wlodek, M. E., Mühlhäusler, B. S., Payne, M. S., & Stinson, L. F. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab011 · Cited by 55
Impact of dietary fibers in infant formulas on gut microbiota and the intestinal immune barrier
Kong, C., Faas, M. M., de Vos, P., & Akkerman, R. (2020) · Food & Function · doi:10.1039/d0fo01700k · Cited by 51
Patrignani, F., Siroli, L., Parolin, C., Serrazanetti, D. I., Vitali, B., & Lanciotti, R. (2019) · PLOS ONE · doi:10.1371/journal.pone.0208906 · Cited by 51
Microbial modulation of the gut microbiome for treating autoimmune diseases
Balakrishnan, B., & Taneja, V. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1517044 · Cited by 51
Metadata
- Authors
- Tanaka, M., & Nakayama, J.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Nakayama, Jiro
- Venue
- Allergology International
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 66
- Issue
- 4
- Pages
- 515-522
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2746392566
- Cited by
- 639
- References
- 130
- Citations by year
- 2026: 41 · 2025: 69 · 2024: 72 · 2023: 75 · 2022: 99 · 2021: 101 · 2020: 92 · 2019: 62 · 2018: 25 · 2017: 3
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (17H04620, 25304006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, infancy, microbial colonization, immune system development, allergic diseases, environmental factors, long-term health, digestive tract development, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Age Factors, Animals, Anti-Bacterial Agents, Disease Susceptibility, Food, Health Status, Humans, Hypersensitivity, Immune System, Infant, Infant, Newborn, Milk, Human, Delivery, Obstetric, Biodiversity, Host-Pathogen Interactions, Microbiota
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