The DOI matches its Crossref record; 129 of the 130 references it cites were found in a registry or an index.
Development of the gut microbiota in infancy and its impact on health in later life
Open accessAbstract
Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.
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“As described in the introduction it is the first three years of life that diet, together with other factors, appears to have the greatest impact on microbial ecology [11].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [11]
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Items 601–635 of 635
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“The establishment of a stable gut microbiota in infants involves two major transitional phases (Tanaka and Nakayama, 2017).”
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“Foundational developmental studies provide strong biological plausibility, 38 while large-scale population analyses offer robust epidemiological insight.”
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Babu, P., Prakash, V., Subhash, S., Vanuopadath, M., Haripriyan, J., Rajan, K., Anu, A. G., Padmakumar, S., Kumar, G. B., Nair, B. G., et al. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1905445 · Cited by 1
“…relationships that develop, particularly after birth, are fundamental for enabling normal metabolic processes, comprehensive immune development, and effective anti-infectious defenses, all contributing to overall gut homeostasis and mucosal integrity (Tanaka and Nakayama, 2017; Zheng et al., 2020).”
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Metadata
- Authors
- Tanaka, M., & Nakayama, J.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Nakayama, Jiro
- Venue
- Allergology International
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 66
- Issue
- 4
- Pages
- 515-522
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2746392566
- Cited by
- 639
- References
- 130
- Citations by year
- 2026: 41 · 2025: 69 · 2024: 72 · 2023: 75 · 2022: 99 · 2021: 101 · 2020: 92 · 2019: 62 · 2018: 25 · 2017: 3
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (17H04620, 25304006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, infancy, microbial colonization, immune system development, allergic diseases, environmental factors, long-term health, digestive tract development, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Age Factors, Animals, Anti-Bacterial Agents, Disease Susceptibility, Food, Health Status, Humans, Hypersensitivity, Immune System, Infant, Infant, Newborn, Milk, Human, Delivery, Obstetric, Biodiversity, Host-Pathogen Interactions, Microbiota
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