Development of the gut microbiota in infancy and its impact on health in later life

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

Enterotypes of the human gut microbiome

MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

Role of the microbiota in immunity and inflammation.

Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

The impact of the gut microbiota on human health: an integrative view

Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058

Development of the Human Infant Intestinal Microbiota

Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877

The Placenta Harbors a Unique Microbiome

Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494

Inducible Foxp3 + regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233

Factors influencing the composition of the intestinal microbiota in early infancy

Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232

Early infancy microbial and metabolic alterations affect risk of childhood asthma

Arrieta, M., Stiemsma, L. T., Dimitriu, P. A., Thorson, L., Russell, S., Yurist‐Doutsch, S., Kuzeljevic, B., Gold, M. J., Britton, H. M., Lefebvre, D. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab2271 · Cited by 1,832

Interactions between commensal intestinal bacteria and the immune system

Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,530

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

Vatanen, T., Kostic, A. D., d’Hennezel, E., Siljander, H., Franzosa, E. A., Yassour, M., Kolde, R., Vlamakis, H., Arthur, T. D., Hämäläinen, A.-M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.007 · Cited by 1,289

Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing

Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255

Allergy development and the intestinal microflora during the first year of life

Björkstén, B., Sepp, E., Julge, K., Voor, T., & Mikelsaar, M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118130 · Cited by 1,203

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

Fujimura, K. E., Sitarik, A. R., Havstad, S. L., Lin, D. L., Levan, S., Fadrosh, D. W., Panzer, A. R., LaMere, B. J., Rackaityte, E., Lukacs, N. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4176 · Cited by 1,198

ATP drives lamina propria TH17 cell differentiation

Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089

Th17 cell induction by adhesion of microbes to intestinal epithelial cells

Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., Suda, W., Imaoka, A., Setoyama, H., Nagamori, T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.058 · Cited by 1,071

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction

Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., & Koga, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1739 · Cited by 1,070

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

Azad, M. B., Konya, T., Maughan, H., Guttman, D. S., Field, C. J., Chari, R. S., Sears, M. R., Becker, A. B., Scott, J. A., & Kozyrskyj, A. L. (2013) · Canadian Medical Association Journal · doi:10.1503/cmaj.121189 · Cited by 989

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

Langdon, A. E., Crook, N., & Dantas, G. A. (2016) · Genome Medicine · doi:10.1186/s13073-016-0294-z · Cited by 968

Is meconium from healthy newborns actually sterile?

Jiménez, E., Marín, M. L., Martı́n, R., Odriozola, J. M., Olivares, M. M., Xaus, J., Fernández, L., & Rodríguez, J. M. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2007.12.007 · Cited by 944

The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery

Cabrera-Rubio, R., Collado, M. C., Laitinen, K., Salminen, S., Isolauri, E., & Mira, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037382 · Cited by 886

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P. M., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012) · Nature · doi:10.1038/nature10772 · Cited by 862

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840

Low diversity of the gut microbiota in infants with atopic eczema

Abrahamsson, T., Jakobsson, H. E., Andersson, A. F., Björkstén, B., Engstrand, L. G., & Jenmalm, M. C. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.025 · Cited by 833

Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based Investigation

DiGiulio, D. B., Romero, R. J., Amogan, H., Kusanovic, J. P., Bik, E. M., Gotsch, F., Kim, C. J., Erez, O., Edwin, S. S., & Relman, D. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003056 · Cited by 808

The role of microbiome in central nervous system disorders

Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age

Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B. L. K., Skov, T., Paludan-Müller, G., Stokholm, J., Smith, B., & Krogfelt, K. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.060 · Cited by 786

Xanthomonas citri MinC Oscillates from Pole to Pole to Ensure Proper Cell Division and Shape

Lorenzoni, A. S. G., Dantas, G. C., Bergsma, T., Ferreira, H., & Scheffers, D. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01352 · Cited by 727

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., & Fagarasan, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307317101 · Cited by 721

Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M., & Tsuchida, T. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.19 · Cited by 700

Isolation of Commensal Bacteria from Umbilical Cord Blood of Healthy Neonates Born by Cesarean Section

Jiménez, E., Fernández, L., Marín, M. L., Martı́n, R., Odriozola, J. M., Nueno‐Palop, C., Narbad, A., Olivares, M. M., Xaus, J., & Rodríguez, J. M. (2005) · Current Microbiology · doi:10.1007/s00284-005-0020-3 · Cited by 681

The gut microbiota: a major player in the toxicity of environmental pollutants?

Claus, S. P., Guillou, H., & Ellero-Simatos, S. (2016) · npj Biofilms and Microbiomes · doi:10.1038/npjbiofilms.2016.3 · Cited by 678

A global survey of changing patterns of food allergy burden in children

Prescott, S. L., Pawankar, R., Allen, K. J., Campbell, D. E., Sinn, J. K. H., Fiocchi, A. G., Ebisawa, M., Sampson, H. A., Beyer, K., & Lee, B. W. (2013) · World Allergy Organization Journal · doi:10.1186/1939-4551-6-21 · Cited by 606

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., & Honjo, T. (2002) · Science · doi:10.1126/science.1077336 · Cited by 590

Exposure to endotoxin or other bacterial components might protect against the development of atopy

Mutius, V., Braun‐Fahrländer, Schierl, Riedler, Ehlermann, Maisch, Waser, & Nowak (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00959.x · Cited by 579

Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways

Marcobal, A., Barboza, M., Sonnenburg, E. D., Pudlo, N., Martens, E. C., Desai, P., Lebrilla, C. B., Weimer, B. C., Mills, D. A., German, J. B., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.007 · Cited by 574

Consumption of human milk oligosaccharides by gut-related microbes

Marcobal, A., Barboza, M., Froehlich, J. W., Block, D. E., German, J. B., Lebrilla, C. B., & Mills, D. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9044205 · Cited by 568

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

Bunker, J. J., Flynn, T. M., Koval, J., Shaw, D. G., Meisel, M., McDonald, B. D., Ishizuka, I. E., Dent, A. L., Wilson, P. C., Jabrì, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.007 · Cited by 561

The Immunological Components of Human Milk and Their Effect on Immune Development in Infants ,

Field, C. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.1.1 · Cited by 557

Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants

Bergström, A., Skov, T. H., Bahl, M. I., Roager, H. M., Christensen, L. B., Ejlerskov, K. T., Mølgaard, C., Michaelsen, K. F., & Licht, T. R. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00342-14 · Cited by 532

High-Throughput Sequencing Reveals the Incomplete, Short-Term Recovery of Infant Gut Microbiota following Parenteral Antibiotic Treatment with Ampicillin and Gentamicin

Fouhy, F., Guinane, C. M., Hussey, S., Wall, R., Ryan, C. A., Dempsey, E. M., Murphy, B. P., Ross, R. P., Fitzgerald, G. F., Stanton, C., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00789-12 · Cited by 518

Infant gut microbiota and food sensitization: associations in the first year of life

Azad, M. B., Konya, T., Guttman, D. S., Field, C. J., Sears, M. R., HayGlass, K. T., Mandhane, P. J., Turvey, S. E., Subbarao, P., Becker, A. B., et al. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12487 · Cited by 517

The subgingival microbial flora during pregnancy

Kornman, K. S., & Loesche, W. J. (1980) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1980.tb00265.x · Cited by 504

Inhibition of Staphylococcus aureus by the commensal bacteria of human milk

Heikkilä, M., & Saris, P. E. J. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02002.x · Cited by 501

Prevalence and Diversity of Microbes in the Amniotic Fluid, the Fetal Inflammatory Response, and Pregnancy Outcome in Women with Preterm Pre‐Labor Rupture of Membranes

DiGiulio, D. B., Romero, R. J., Kusanovic, J. P., Gómez, R., Kim, C. J., Seok, K. S., Gotsch, F., Mazaki‐Tovi, S., Vaisbuch, E., Sanders, K. M., et al. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00830.x · Cited by 466

Cesarean Delivery May Affect the Early Biodiversity of Intestinal Bacteria1,

Biasucci, G., Benenati, B., Morelli, L., Bessi, E., & Boehm, G. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.9.1796s · Cited by 458

Early-life gut microbiome composition and milk allergy resolution

Bunyavanich, S., Shen, N., Grishin, A. V., Wood, R. A., Burks, W. A., Dawson, P. M., Jones, S. M., Leung, D. Y. M., Sampson, H. A., Sicherer, S. H., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.03.041 · Cited by 446

Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter

Greenwood, C., Morrow, A. L., Lagomarcino, A. J., Altaye, M., Taft, D. H., Yu, Z., Newburg, D. S., Ward, D. V., & Schibler, K. R. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.010 · Cited by 416

Regulation of the T cell response

Romagnani, S. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02606.x · Cited by 413

Breast-v.formula-feeding: impacts on the digestive tract and immediate and long-term health effects

Le Huërou-Luron, I., Blat, S., & Boudry, G. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000065 · Cited by 407

Bacterial Diversity in Meconium of Preterm Neonates and Evolution of Their Fecal Microbiota during the First Month of Life

Moles, L., Gómez, M., Heilig, H. G. H. J., Bustos, G., Fuentes, S., de Vos, W. M., Fernández, L., Rodríguez, J. M., & Jiménez, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066986 · Cited by 400

Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants

Gosalbes, M. J., Llop, S., Vallès, Y., Moyá, A., Ballester, F., & Francino, M. P. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12063 · Cited by 399

Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota

Tanaka, S., Kobayashi, T., Songjinda, P., Tateyama, A., Tsubouchi, M., Kiyohara, C., Shirakawa, T., Sonomoto, K., & Nakayama, J. (2009) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2009.00553.x · Cited by 396

Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres

Fallani, M., Amarri, S., Uusijärvi, A., Adam, R., Khanna, S., Aguilera, J., Gil, Á., Vieites, J. M., Norin, E. L., Young, D., et al. (2011) · Microbiology · doi:10.1099/mic.0.042143-0 · Cited by 393

Altered Fecal Microbiota Composition Associated with Food Allergy in Infants

Ling, Z., Li, Z., Liu, X., Cheng, Y., Luo, Y., Tong, X., Li, Y., Wang, Y., Sun, J., Li, L., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00003-14 · Cited by 385

A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

Matsuki, T., Yahagi, K., Mori, H., Matsumoto, H., Hara, T., Tajima, S., Ogawa, E., Kodama, H., Yamamoto, K., Yamada, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms11939 · Cited by 381

Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches

Jost, T., Lacroix, C., Braegger, C., & Chassard, C. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000597 · Cited by 371

Dynamics of Infant Gut Microbiota Are Influenced by Delivery Mode and Gestational Duration and Are Associated with Subsequent Adiposity

Dogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Lee, Y. S., Yap, F. K. P., Chong, Y. S., et al. (2015) · mBio · doi:10.1128/mbio.02419-14 · Cited by 359

Human milk: a source of more life than we imagine

Jeurink, P. V., van Bergenhenegouwen, J., Jiménez, E., Knippels, L. M. J., Fernández, L., Garssen, J., Knol, J., Rodríguez, J. M., & Martín, R. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0040 · Cited by 354

Caesarean section delivery and the risk of allergic disorders in childhood

Renz‐Polster, H., David, M., Buist, A. S., Vollmer, W. M., O’Connor, E., Frazier, E. A., & Wall, M. A. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02356.x · Cited by 339

Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses: Gut microbiota and immune responses

Sjögren, Y. M., Tomicic, S., Lundberg, A., Böttcher, M. F., Björkstén, B., Sverremark‐Ekström, E., & Jenmalm, M. C. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03326.x · Cited by 337

Mucosal immunity: integration between mother and the breast-fed infant

Brandtzaeg, P. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00338-4 · Cited by 320

Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States

Lin, A., Bik, E. M., Costello, E. K., Dethlefsen, L., Haque, R., Relman, D. A., & Singh, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053838 · Cited by 314

Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans

Sakamoto, I., Igarashi, M., Kimura, K., Takagi, A., Miwa, T., & Koga, Y. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/47.5.709 · Cited by 304

Diversity in gut bacterial community of school-age children in Asia

Nakayama, J., Watanabe, K., Jiang, J., Matsuda, K., Chao, S.-H., Haryono, P., La-ongkham, O., Sarwoko, M.-A., Sujaya, I. N., Zhao, L., et al. (2015) · Scientific Reports · doi:10.1038/srep08397 · Cited by 297

The role of intestinal microbiota and the immune system.

Purchiaroni, F., Tortora, A., Gabrielli, M., Bertucci, F., Gigante, G. E., Ianiro, G., Ojetti, V., Scarpellini, E., & Gasbarrini, A. (2013) · PubMed · Cited by 297

Extensive Modulation of the Fecal Metagenome in Children With Crohn’s Disease During Exclusive Enteral Nutrition

Quince, C., Ijaz, U. Z., Loman, N. J., Eren, A. M., Saulnier, D. M. A., Russell, J. A., Haig, S., Calus, S., Quick, J., Barclay, A. R., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.357 · Cited by 285

Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function

Chichlowski, M., De Lartigue, G., German, J. B., Raybould, H. E., & Mills, D. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824fb899 · Cited by 276

Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations

Kumar, H., du Toit, E., Kulkarni, A., Aakko, J., Linderborg, K. M., Zhang, Y., Nicol, M. P., Isolauri, E., Yang, B., Collado, M. C., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01619 · Cited by 271

Lactobacilli and Bifidobacteria in Human Breast Milk

Soto, A., Martín, V., Jiménez, E., Mader, I., Rodríguez, J. M., & Fernández, L. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000347 · Cited by 265

Immunology of breast milk

Palmeira, P., & Carneiro-Sampaio, M. M. S. (2016) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.62.06.584 · Cited by 257

Comparative Metagenomics and Population Dynamics of the Gut Microbiota in Mother and Infant

Vaishampayan, P., Kuehl, J. V., Froula, J. L., Morgan, J. L., Ochman, H., & Francino, M. P. (2010) · Genome Biology and Evolution · doi:10.1093/gbe/evp057 · Cited by 248

Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants

Gregory, K. E., Samuel, B. S., Houghteling, P. D., Shan, G., Ausubel, F. M., Sadreyev, R. I., & Walker, W. A. (2016) · Microbiome · doi:10.1186/s40168-016-0214-x · Cited by 244

A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome

Codling, C., O’Mahony, L., Shanahan, F., Quigley, E. M. M., & Marchesi, J. R. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0934-x · Cited by 243

Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques

Romero, R. J., Miranda, J., Kusanovic, J. P., Chaiworapongsa, T., Chaemsaithong, P., Martinez, A., Gotsch, F., Dong, Z., Ahmed, A. I., Shaman, M., et al. (2015) · Journal of Perinatal Medicine · doi:10.1515/jpm-2014-0249 · Cited by 235

Early Development of the Gut Microbiota and Immune Health

Francino, M. P. (2014) · Pathogens · doi:10.3390/pathogens3030769 · Cited by 232

Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

Kang, J.-H., Yun, S.-I., Park, M.-H., Park, J.-H., Jeong, S.-Y., & Park, H.-O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054617 · Cited by 230

Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants

He, F., Ouwehand, A. C., Isolauri, E., Hashimoto, H., Benno, Y., & Salminen, S. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb01548.x · Cited by 220

Microbial Succession in the Gut: Directional Trends of Taxonomic and Functional Change in a Birth Cohort of Spanish Infants

Vallès, Y., Artacho, A., Pascual‐García, A., Ferrús, M. L., Gosalbes, M. J., Abellan, J. J., & Francino, M. P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004406 · Cited by 217

Lactobacillus rhamnosusCNCM I-3690 and the commensal bacteriumFaecalibacterium prausnitziiA2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice

Laval, L., Martín, R., Natividad, J. M., Chain, F., Miquel, S., de Maredsous, C. D., Capronnier, S., Sokol, H., Verdu, E. F., Vlieg, J. E. T. V. H., et al. (2014) · Gut Microbes · doi:10.4161/19490976.2014.990784 · Cited by 215

Advances in Quantitative Hepcidin Measurements by Time-of-Flight Mass Spectrometry

Swinkels, D. W., Girelli, D., Laarakkers, C. M., Kroot, J. J., Campostrini, N., Kemna, E., & Tjalsma, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002706 · Cited by 205

Alterations in the gut microbiotas of children with food sensitization in early life

Chen, C., Chen, K., Kong, M., Chang, H., & Huang, J. (2015) · Pediatric Allergy and Immunology · doi:10.1111/pai.12522 · Cited by 194

Asthma and the microbiome: defining the critical window in early life

Stiemsma, L. T., & Turvey, S. E. (2017) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-016-0173-6 · Cited by 189

Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease

Kirjavainen, P. V., Apostolou, E., Arvola, T., Salminen, S., Gibson, G. R., & Isolauri, E. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00526.x · Cited by 186

Healthy immune response to allergens: T regulatory cells and more

Akdis, M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.06.003 · Cited by 174

Physiological and bifidogenic effects of prebiotic supplements in infant formulae

Veereman‐Wauters, G., Staelens, S., Van de Broek, H., Plaskie, K., Wesling, F., Roger, L., McCartney, A., & Assam, P. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182139f39 · Cited by 171

Impact of Westernized Diet on Gut Microbiota in Children on Leyte Island

Nakayama, J., Yamamoto, A., Conde, L. A., Higashi, K., Sonomoto, K., Tan, J. D., & Lee, Y. K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00197 · Cited by 171

Risk Factors for Late-Life Cognitive Decline and Variation with Age and Sex in the Sydney Memory and Ageing Study

Lipnicki, D. M., Sachdev, P. S., Crawford, J., Reppermund, S., Kochan, N. A., Trollor, J. N., Draper, B., Slavin, M. J., Kang, K., Lux, O., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065841 · Cited by 160

Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children

Majkowska–Wojciechowska, B., Pełka, J., Korzon, L., Kozłowska, A., Kaczała, M., Jarzębska, M., Gwardys, T., & Kowalski, M. L. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01457.x · Cited by 148

Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice

Miyoshi, M., Ogawa, A., Higurashi, S., & Kadooka, Y. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0568-9 · Cited by 144

Breast Milk Fatty Acids, Eicosanoids, and Cytokines in Mothers with and without Allergic Disease

Laiho, K., Lampi, A., Hämäläinen, M., Moilanen, E., Piironen, V. I., Arvola, T., Syrjänen, S., & Isolauri, E. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000055778.58807.c8 · Cited by 124

Mucosal macrophages and the regulation of immune responses in the intestine

Platt, A. M., & Mowat, A. M. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.05.009 · Cited by 120

Breast-feeding, infant formulas, and the immune system

Hanson, L. Å., Korotkova, M., & Telemo, E. (2003) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61662-6 · Cited by 120

Development of Functional Foods

MITSUOKA, T. (2014) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.33.117 · Cited by 111

Gut resistome development in healthy twin pairs in the first year of life

Moore, A. M., Ahmadi, S., Patel, S., Gibson, M. K., Wang, B., Ndao, I. M., Deych, E., Shannon, W., Tarr, P. I., Warner, B. B., et al. (2015) · Microbiome · doi:10.1186/s40168-015-0090-9 · Cited by 109

Lacto-N-biosidase Encoded by a Novel Gene of Bifidobacterium longum Subspecies longum Shows Unique Substrate Specificity and Requires a Designated Chaperone for Its Active Expression

Sakurama, H., Kiyohara, M., Wada, J., Honda, Y., Yamaguchi, M., Fukiya, S., Yokota, A., Ashida, H., Kumagai, H., Kitaoka, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.484733 · Cited by 102

The anti-obesity effects ofLactobacillus caseistrain Shirota versus Orlistat on high fat diet-induced obese rats

Karimi, G., Sabran, M. R., Jamaluddin, R., Parvaneh, K., Mohtarrudin, N., Ahmad, Z., Khaza’ai, H., & Khodavandi, A. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.29273 · Cited by 102

Microbial Community of Healthy Thai Vegetarians and Non-Vegetarians, Their Core Gut Microbiota, and Pathogen Risk

Ruengsomwong, S., La-ongkham, O., Jiang, J., Wannissorn, B., Nakayama, J., & Nitisinprasert, S. (2016) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1603.03057 · Cited by 102

Distinct Pattern of Commensal Gut Microbiota in Toddlers with Eczema

Mah, K. W., Björkstén, B., Lee, B. W., Bever, H. P. V., Shek, L. P., Tan, T. N., Lee, Y. K., & Chua, K. Y. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000092555 · Cited by 101

Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children

Decker, E., Hornef, M. W., & Stockinger, S. (2011) · Gut Microbes · doi:10.4161/gmic.2.2.15414 · Cited by 95

Rate of establishing the gut microbiota in infancy has consequences for future health

Dogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Karnani, N., Lee, Y. S., Yap, F. K. P., et al. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1078051 · Cited by 95

Microbiome and food allergy

Blázquez, A. B., & Berin, M. C. (2016) · Translational research · doi:10.1016/j.trsl.2016.09.003 · Cited by 93

The microbiome and development of allergic disease

Lynch, S. V., & Boushey, H. A. (2016) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0000000000000255 · Cited by 92

Faecal short chain fatty acid pattern and allergy in early childhood

Sandin, A., Bråbäck, L., Norin, E. L., & Björkstén, B. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.01215.x · Cited by 90

Aberrant structures of fecal bacterial community in allergic infants profiled by 16S rRNA gene pyrosequencing

Nakayama, J., Kobayashi, T., Tanaka, S., Korenori, Y., Tateyama, A., Sakamoto, N., Kiyohara, C., Shirakawa, T., & Sonomoto, K. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00872.x · Cited by 88

Clostridia isolated from the feces of infants during the first year of life

Stark, P. L., & Lee, A. (1982) · The Journal of Pediatrics · doi:10.1016/s0022-3476(82)80430-7 · Cited by 80

The allergy‐protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide

Debarry, J., Hanuszkiewicz, A., Stein, K., Holst, O., & Heine, H. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02253.x · Cited by 77

Immune Factors in Breast Milk and the Development of Atopic Disease

Iyengar, S. R., & Walker, W. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182617a9d · Cited by 69

The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy

Nguyen, Q. N., Himes, J. E., Martinez, D. R., & Permar, S. R. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005997 · Cited by 68

Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood

Tanaka, M., Korenori, Y., Washio, M., Kobayashi, T., Momoda, R., Kiyohara, C., Kuroda, A., Saito, Y., Sonomoto, K., & Nakayama, J. (2017) · FEMS Microbiology Ecology · doi:10.1093/femsec/fix099 · Cited by 67

Early gut colonization by Bifidobacterium breve and B. catenulatum differentially modulates eczema risk in children at high risk of developing allergic disease

Ismail, I. H., Boyle, R. J., Licciardi, P. V., Oppedisano, F., Lahtinen, S. J., Robins-Browne, R. M., & Tang, M. L. K. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12646 · Cited by 58

Prevention of food allergy – Early dietary interventions

Toit, G. D., Foong, R.-X. M., & Lack, G. (2016) · Allergology International · doi:10.1016/j.alit.2016.08.001 · Cited by 51

The role of IL-10 in microbiome-associated immune modulation and disease tolerance

Levast, B., Li, Z., & Madrenas, J. (2014) · Cytokine · doi:10.1016/j.cyto.2014.11.027 · Cited by 47

Mouse Models for Assessing the Protective Efficacy ofLactobacillus gasseri SBT 2055 againstHelicobacter suisInfection Associated with the Development of Gastric Mucosa‐Associated Lymphoid Tissue Lymphoma

Matsui, H., Takahashi, T., Øverby, A., Murayama, S. Y., Yoshida, H., Yamamoto, Y., Nishiyama, K., Seto, Y., Takahashi, T., Mukai, T., et al. (2015) · Helicobacter · doi:10.1111/hel.12203 · Cited by 29

Use of gnotobiotic mice to identify and characterize key microbes responsible for the development of the intestinal immune system

Umesaki, Y. (2014) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.90.313 · Cited by 28

Microbiome/microbiota and allergies

Inoue, Y., & Shimojo, N. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0453-5 · Cited by 23

Transcriptomic and Metabolomic Analysis Revealed Multifaceted Effects of Phage Protein Gp70.1 on Pseudomonas aeruginosa

Zhao, X., Chen, C., Jiang, X., Shen, W., Huang, G., Le, S., Lu, S., Zou, L., Ni, Q., Li, M., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01519 · Cited by 22

Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016

and the Canadian Healthy Infant Longitudinal Development Study Investigators, Alsayegh, M. A., Alshamali, H., Khadada, M., Ciccolini, A., Ellis, A. K., Quint, D. J., Powley, W. M., Lee, L. A., Fiteih, Y., et al. (2017) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-017-0192-y · Cited by 8

Effects of Probiotics on the Immune System and Allergic Diseases

Shimojo, N., Suzuki, S., Campos‐Alberto, E., & Kohno, Y. (2005) · Allergology International · doi:10.2332/allergolint.54.515 · Cited by 4

What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases

Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019) · Microorganisms · doi:10.3390/microorganisms7010014 · Cited by 3,462

The gut microbiota in anxiety and depression—A systematic review

Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912

Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration

Leeming, E. R., Johnson, A. J., Spector, T. D., & Le Roy, C. I. (2019) · Nutrients · doi:10.3390/nu11122862 · Cited by 817

Gut Microbiota and Obesity: A Role for Probiotics

Abenavoli, L., Scarpellini, E., Colica, C., Boccuto, L., Salehi, B., Sharifi-Rad, J., Aiello, V., Romano, B., De Lorenzo, A., Izzo, A. A., et al. (2019) · Nutrients · doi:10.3390/nu11112690 · Cited by 615

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 513

Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease

Donald, K., & Finlay, B. B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00874-w · Cited by 394

The first thousand days - intestinal microbiology of early life: Establishing a symbiosis

Wopereis, H., Oozeer, R., Knipping, K., Belzer, C., & Knol, J. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12232 · Cited by 352

Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies

Pirker, A.-L., & Vogl, T. J. (2024) · Frontiers in Allergy · doi:10.3389/falgy.2024.1439303 · Cited by 15

Correlation between early-life regulation of the immune system by microbiota and allergy development

Gensollen, T., & Blumberg, R. S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.011 · Cited by 147

How the early life microbiome shapes immune programming in childhood asthma and allergies

Hoskinson, C., Petersen, C., & Turvey, S. E. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.12.005 · Cited by 28