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The role of gastrointestinal permeability in food allergy

Samadi, Nazanin, Klems, Martina, Untersmayr, Eva·2018·Annals of Allergy, Asthma & Immunology
DOI 10.1016/j.anai.2018.05.010
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Abstract

Key Messages•Selective intestinal epithelial permeability is essential for uptake of water and nutrients and contributes to oral tolerance development.•Altered intestinal epithelial barrier function and composition is observed in food allergy.•Subepithelial mediators and small intestinal luminal content influence barrier integrity.•The gastric milieu and physiological function contribute to antigen separation from the immune induction sites.•A dysfunctional barrier of the entire gastrointestinal tract has an essential contribution to food allergic reactions. •Selective intestinal epithelial permeability is essential for uptake of water and nutrients and contributes to oral tolerance development.•Altered intestinal epithelial barrier function and composition is observed in food allergy.•Subepithelial mediators and small intestinal luminal content influence barrier integrity.•The gastric milieu and physiological function contribute to antigen separation from the immune induction sites.•A dysfunctional barrier of the entire gastrointestinal tract has an essential contribution to food allergic reactions.

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Metadata

Authors
Samadi, N., Klems, M., & Untersmayr, E.
ORCID
Untersmayr, Eva
Venue
Annals of Allergy, Asthma & Immunology
Publisher
Elsevier BV
Published
2018-08
Volume
121
Issue
2
Pages
168-173
ISSN
1081-1206
DOI
10.1016/j.anai.2018.05.010
Cited by
95
References
6
Language
en
Licence
Funders
  • Austrian Science Fund (KLI284-B00)
  • BMWFW-AWS PRIZE (P1621673)
  • Nordmark GmbH

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CoChat. (2026). Citation check: The role of gastrointestinal permeability in food allergy. https://app.cochat.ai/papers/10.1016/j.anai.2018.05.010
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Samadi, N., Klems, M., & Untersmayr, E. (2018). The role of gastrointestinal permeability in food allergy. Annals of Allergy, Asthma & Immunology. https://doi.org/10.1016/j.anai.2018.05.010