Physiotherapy for Sleep Disturbance in People With Chronic Low Back Pain: Results of a Feasibility Randomized Controlled Trial
Abstract
Objective To determine the feasibility of a randomized controlled trial investigating the effectiveness of physiotherapy for sleep disturbance in chronic low back pain (CLBP) (≥12wks).Design Randomized controlled trial with evaluations at baseline, 3 months, and 6 months.Setting Outpatient physiotherapy department in an academic teaching hospital.Participants Participants with CLBP were randomly assigned to a walking program (n=20; mean age ± SD, 46.4±13.8y), supervised exercise class (n=20; mean age ± SD, 41.3±11.9y), or usual physiotherapy (n=20; mean age ± SD, 47.1±14.3y). The 3-month evaluation was completed by 44 participants (73%), and 42 (70%) participants completed the 6-month evaluation.Interventions Participants received a physiotherapy-delivered 8-week walking program, an 8-week group supervised exercise class (1 class/wk), or 1-to-1 usual physiotherapy (advice, manual therapy, and exercise).Main outcome measures Sleep was assessed by the self-reported Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Pittsburgh Sleep Diary, and objective actigraphy.Results Groups were comparable at baseline. Most (95%, n=57) of the participants had sleep disturbance. The acceptability of actigraphy was excellent at baseline (58 of 60 participants), but dropped at 3 months (26 of 44 participants). There were improvements on the PSQI and ISI in all groups at 3 and 6 months, with predominantly medium effect sizes (Cohen d=0.2-0.5).Conclusions The high prevalence of sleep disturbance indicated the feasibility of good recruitment in future trials. The PSQI would be a suitable screening tool and outcome measure alongside an objective nonobtrusive sleep outcome measure. The effectiveness of physiotherapy for sleep disturbance in CLBP warrants investigation in a fully powered randomized controlled trial.
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Eadie et al. found medium size effects in all groups according to ISI and Pittsburgh Sleep Quality Index.
“They found medium size effects in all groups according to ISI and Pittsburgh Sleep Quality Index.”
From Is sleep disturbance in patients with chronic pain affected by physical exercise or ACT-based stress management? - A randomized controlled study (2018) · cites this paper as [11]
Eadie et al. randomized chronic low back pain patients with sleep disturbance (N=60) into three different forms of physiotherapy/exercise including an active control group.
“One exception is Eadie, et al. [11] who randomized chronic low back pain patients with sleep disturbance (N = 60) into three different forms of physiotherapy/exercise including an active control group.”
From Is sleep disturbance in patients with chronic pain affected by physical exercise or ACT-based stress management? - A randomized controlled study (2018) · cites this paper as [11]
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“Medication, exercise therapy, spinal manipulation, and cognitive behavior therapy are all examples of treatments with conflicting results for management of back pain [11, 12].”
BackgroundSelf-citationCognitive Behavioral Therapy for Insomnia in Pain Management for Nonspecific Chronic Spinal Pain
Malfliet, A., Baets, L. D., Bilterys, T., Looveren, E. V., Maîresse, O., Cagnie, B. J., Meeus, M., Moens, M., Goubert, D., Munneke, W., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.25856 · Cited by 22 · see citing works
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“It is also common for sleep diary data to be collected alongside objective sleep data to monitor lifestyle factors which may interfere with the sleepwake cycle, although this was not within scope of our study.(32,33) Participants were asked to complete the sleep diaries for five days within the home study week and day…”
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The effect of renal transplantation on quality of sleep in former dialysis patients
Brekke, F. B., Waldum-Grevbo, B. E., von der Lippe, N., & Os, I. (2016) · Transplant International · doi:10.1111/tri.12866 · Cited by 22 · see citing works
“methods are available, but pragmatically, we have chosen a distribution-based method [34,35], which also has been used in other study populations [36,37].”
MethodRisk Factors for Low Back Pain and Spine Surgery
Kardouni, J. R., Shing, T. L., & Rhon, D. I. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2016.06.005 · Cited by 21 · see citing works
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Pascoe, S. C., Spoonemore, S. L., Young, J. L., & Rhon, D. I. (2022) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2022.05.002 · Cited by 18 · see citing works
Association Between Sleep Disturbance and Low Back Pain
Yabe, Y., Hagiwara, Y., Sekiguchi, T., Sugawara, Y., Tsuchiya, M., Yoshida, S., & Tsuji, I. (2021) · Spine · doi:10.1097/brs.0000000000004234 · Cited by 17 · see citing works
“Multiple logistic regression analysis was performed to assess the association between the duration or frequency of sleep disturbance and LBP, and the effect of preceding sleep disturbance on the onset of LBP.”
BackgroundInfluentialGroote, S. D., Goudman, L., Peeters, R. R., Linderoth, B., Schuerbeek, P. V., Sunaert, S. G., Jaeger, M. D., Smedt, A. D., Andrés, J. A. D., & Moens, M. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102087 · Cited by 17 · see citing works
Hurley, D. A., Jeffares, I., Hall, A. M., Keogh, A., Toomey, E. C., McArdle, D., Lonsdale, C., Guérin, S., Guerin, S., Segurado, R., et al. (2020) · Trials · doi:10.1186/s13063-020-04671-x · Cited by 17 · see citing works
“This is a higher attendance rate than other RCTs of the 6-week group interventions for CLBP delivered in the Irish health service [32, 33], and comparable to the ESCAPE-knee pain intervention in the UK health service [15].”
ResultSelf-citationBilterys, T., Looveren, E. V., Malfliet, A., Nijs, J., Meeus, M., Danneels, L. A., Ickmans, K., Cagnie, B. J., Goubert, D., Moens, M., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002901 · Cited by 16 · see citing works
Clinically Important Change in Insomnia Severity After Chronic Pain Rehabilitation
Wilson, K. G., Kowal, J., & Ferguson, E. J. (2016) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000325 · Cited by 15 · see citing works
Robertson, B., & Harding, K. E. (2014) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2014.07.005 · Cited by 15 · see citing works
“Meta-analysis of outcomes for individual vs. group physical therapy for patients with urinary 554 incontinence 555 556 557 M AN US CR IP T AC CE PT ED Abbreviations: LBP, low back pain; RCT, randomised controlled trials; PT, physical therapy; MSPQ, Modified Somatic Perception Questionnaire Eadie et al 2013 Single blin…”
BackgroundInfluentialMikkonen, J., Leinonen, V., Luomajoki, H. A., Kaski, D. N., Kupari, S., Tarvainen, M. P., Selander, T. A., & Airaksinen, O. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214887 · Cited by 13 · see citing works
“Previous studies have reported associations between various other pain–sleep questionnaires and actigraphy measurements among subjects with chronic musculoskeletal pain [2,25,26]; however, the relationship between actigraphy measurements and the PSQ-3 has not yet been studied.”
BackgroundSarı, S. (2015) · Ağrı - The Journal of The Turkish Society of Algology · doi:10.5505/agri.2015.91489 · Cited by 13 · see citing works
Sleep quality in patients with chronic low back pain
França, V. L., Koerich, M. H. A. D. L., & Nunes, G. S. (2015) · Fisioterapia em Movimento · doi:10.1590/0103-5150.028.004.ao17 · Cited by 12 · see citing works
Sany, S. A., Mitsi, M., Tanjim, T., & Rahman, M. (2023) · F1000Research · doi:10.12688/f1000research.75440.2 · Cited by 10 · see citing works
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Ughreja, R. A., Venkatesan, P., Gopalakrishna, D. B., Singh, Y. P., & Vani Lakshmi, R. (2024) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2024.06.003 · Cited by 9 · see citing works
Vægter, H. B., Høybye, M. T., Bergen, F. H., & Parsons, C. E. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2020-0155 · Cited by 9 · see citing works
Walking away from back pain: one step at a time – a community-based randomised controlled trial
Milosavljevic, S., Clay, L., Bath, B. L., Trask, C., Penz, E. D., Stewart, S. A., Hendrick, P. A., Baxter, D. G., Hurley, D. A., & McDonough, S. (2015) · BMC Public Health · doi:10.1186/s12889-015-1496-9 · Cited by 9 · see citing works
“Interestingly, although walking is recognised as a fundamental human activity, there is limited literature on its use as an intervention strategy for CLBP [14,17-21].”
BackgroundSelf-citationRelationship between Low Back Pain and Sleep Quality
Siengsukon, C. F. (2013) · Journal of Novel Physiotherapies · doi:10.4172/2165-7025.1000168 · Cited by 8 · see citing works
“It is reported that 50 to 70 percent of people with chronic LBP have compromised sleep quality [15,27].”
BackgroundLin, J., Lin, L.-P., Su, S.-F., Hsu, S., Chou, Y., Lin, F.-G., Loh, C., Wu, J.-L., & Chu, C. M.-Y. (2014) · Research in Autism · doi:10.1016/j.rasd.2014.03.011 · Cited by 7 · see citing works
Banaei, M., Alizadeh, S., Roozbeh, N., Naz, M. S. G., Taghvaei, E., Parviz, L., & Ghasemi, V. (2025) · BMC Public Health · doi:10.1186/s12889-025-25142-5 · Cited by 6 · see citing works
Bilterys, T., Looveren, E. V., Maîresse, O., Nijs, J., Meeus, M., Ickmans, K., Cagnie, B. J., Goubert, D., Willaert, W., Pauw, R. D., et al. (2022) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2022.100456 · Cited by 4 · see citing works
“One of the most common comorbidities in people with nCSP is insomnia, with prevalence rates exceeding 50%.(8,9) It is well known that physical activity has several physical and psychological health benefits.”
BackgroundMoriki, K., Ogihara, H., Yoshikawa, K., Kikuchi, K., Endo, R., & Sato, T. (2023) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-220429 · Cited by 6 · see citing works
“Physical therapy for sleep disturbance is often recommended for patients with CLBP with no pharma-cotherapy responses [27,47,48].”
Insomnia in chronic non-specific low back pain
Lamkova, I. A., & Parfenov, V. A. (2021) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2021-5-62-67 · Cited by 6 · see citing works
“Улучшение сна на фоне разных видов физической активности указывает на положительное влияние кинезитерапии на нормализацию сна [5].”
InfluentialZhang, F., Zhang, B., Wang, X.-T., Huang, C., & Hu, B.-Y. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1105359 · Cited by 6 · see citing works
“Insomnia and disrupted sleep negatively affect pain, functional ability, anxiety, depression, and the quality of life of patients with CLBP (Akodu and Akindutire, 2018; van de Water et al., 2011).”
BackgroundInfluentialCalvo, S., González, C., Lapuente‐Hernández, D., Cuenca‐Zaldívar, J. N., Herrero, P., & Gil-Calvo, M. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.09.008 · Cited by 5 · see citing works
Peacock, J., Provenzano, D. A., Fishman, M. A., Amirdelfan, K., Bromberg, T. A., Schmidt, T., White, T., Grewal, P. K., Justiz, R., Calodney, A. K., et al. (2024) · Pain Practice · doi:10.1111/papr.13407 · Cited by 4 · see citing works
Examining the prevalence of sleep disturbances in patients seeking physical therapy services
Pfeiffer, A. M., Triplett, C., & Siengsukon, C. F. (2022) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2022.2134754 · Cited by 4 · see citing works
“Two studies found PT interventions may have a positive impact on sleep quality in people with chronic low back pain (Eadie et al., 2013; Roseen et al., 2020).”
BackgroundMenezes-Júnior, L. (2026) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00069-7 · Cited by 3 · see citing works
“All analyses were performed using Stata version 18, employing robust standard errors where appropriate, and were two-sided with signi fi cance set at p < 0.05.”
InfluentialSiengsukon, C. F., Glaser, A., & Nelson, E. (2024) · BMC Medical Education · doi:10.1186/s12909-023-05008-3 · Cited by 3 · see citing works
Sany, S. A., Mitsi, M., Tanjim, T., & Rahman, M. (2022) · F1000Research · doi:10.12688/f1000research.75440.1 · Cited by 12 · see citing works
Rapelli, G., Varallo, G., Scarpelli, S., Pietrabissa, G., Musetti, A., Plazzi, G., Franceschini, C., & Castelnuovo, G. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1144087 · Cited by 3 · see citing works
“Interestingly, the total PSQI decreased from the baseline in both follow-ups, meeting the minimal clinically important difference of ≥3 as suggested by previous evidence (Hughes et al., 2009; Eadie et al., 2013; McDonnell et al., 2014; Weinberg et al., 2020).”
BackgroundNeilson, B. D., Dickerson, C., Young, J. L., Shepherd, M. H., & Rhon, D. I. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10672 · Cited by 4 · see citing works
Smartphone-based non-invasive biofeedback therapy for post-stroke sleep disorders: short report
Park, J., Jung, M., Ha, J., Park, J. J., & Im, S. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1601821 · Cited by 2 · see citing works
Craige, E. A., Vincent, G. E., Belavý, D. L., Ford, J. J., Miller, C. T., Main, L. C., Hahne, A. J., Ferguson, S. A., & Owen, P. J. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106837 · Cited by 3 · see citing works
Ahmad, A., Aldabbas, M. M., Tanwar, T., Iram, I., & Veqar, Z. (2023) · Physiotherapy Quarterly · doi:10.5114/pq.2023.117448 · Cited by 2 · see citing works
Silva, S., Pinto, R. Z., Mendes, G., dos Santos, R. L. G. M., Grade, I., de Mello, M. T., Hayden, J. A., & Silva, A. (2024) · Journal of Aging and Physical Activity · doi:10.1123/japa.2024-0038 · Cited by 2 · see citing works
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Ogbeivor, C. (2020) · Orthopedics and Sports Medicine Open Access Journal · doi:10.32474/osmoaj.2020.04.000191 · Cited by 2 · see citing works
“For example Eadie et al [19], in a pragmatic RCT that investigated exercise versus group biomechanical exercise in chronic low back patients using a one-hour session per week, which is what obtains in every day practice.”
BackgroundNúñez‐Cortés, R., Suso‐Martí, L., Salazar‐Méndez, J., López‐Bueno, R., Cruz‐Montecinos, C., Malhue-Orellana, T., Lang, M., Andersen, L. L., & Calatayud, J. (2026) · PM&R · doi:10.1002/pmrj.70189 · Cited by 1 · see citing works
Siengsukon, C. F. (2021) · Physical Therapy · doi:10.1093/ptj/pzab285 · Cited by 1 · see citing works
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“…also found that eight patients in the LAC- PROB-Zn group (53.3%), two in the LAC-PROB group (13.3%), and none in the control group experienced a clinically significant improvement in sleep quality (PSQI total score reduction ≥ 3 (Eadie et al. 2013; Costandi et al. 2022)), compared to the baseline.”
InfluentialSouza, C. C., Vallim, J. R. D. S., Neves, E. L. D. A., Nunes, P. S., Costa, I. M. P. D. F., Barreto, L. C. L. S., Garcez, C. A., & Araújo, A. A. D. S. (2022) · Sleep Science · doi:10.5935/1984-0063.20220058 · Cited by 1 · see citing works
“Although exercise can alter sleep architecture and improve daytime sleepiness 15,31,34 , we did not observe this effect.”
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“Furthermore, the PSQI-2 demonstrated a reasonable ability to detect those who experienced a clinically meaningful change, de�ned as a > 3 point shift on the full PSQI [19, 20].”
Calidad del sueño en pacientes con lumbalgia crónica inespecífica
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Insomnia Symptoms in Chronic Pain : Clinical presentation, risk and treatment
Wiklund, T. (2021) · Linköping University medical dissertations · doi:10.3384/diss.diva-175373
Physiotherapists: Sleep Health Promoters
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“A randomized controlled trial found that 8 weeks of physiotherapy sessions for adults with chronic low back pain were associated with significant improvements in sleep quality and insomnia symptoms [32].”
Elnaggar, O., Paoletti, P., Hopkinson, A., & Coenen, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22206-1.00004-8
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Whale, K., Dennis, J. A., Wylde, V., Beswick, A. D., & Gooberman-Hill, R. (2022) · Figshare · doi:10.6084/m9.figshare.19753266
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Whale, K., Dennis, J. A., Wylde, V., Beswick, A. D., & Gooberman-Hill, R. (2022) · Figshare · doi:10.6084/m9.figshare.19753269
Efficacy and safety of auriculotherapy for insomnia disorder: A randomized controlled trial
Chen, H., Zhang, X.-F., Yuan, Z., Wang, X.-S., Gao, Y., Li, X.-X., Zhang, J.-C., Oliveira, M. D. D. S., Nunes, C. A. D. B., Liu, J., et al. (2025) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2025.12.009
Muñoz-Bustos, M., Torres, H. N., Ceballos‐Laita, L., Muñoz-Bustos, G. A., Portela, A., & Carrasco‐Uribarren, A. (2026) · Journal of Manual & Manipulative Therapy · doi:10.1080/10669817.2026.2720771
- Authors
- Eadie, J., van de Water, A. T., Lonsdale, C., Tully, M. A., van Mechelen, W., Boreham, C. A., Daly, L., McDonough, S. M., & Hurley, D. A.
- Affiliations
- University College Dublin (IE)
- Queen's University Belfast (GB)
- University of Ulster (GB)
- Corresponding author
- Hurley, Deirdre A.
- ORCID
- Venue
- Archives of Physical Medicine and Rehabilitation
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 94
- Issue
- 11
- Pages
- 2083-2092
- ISSN
- 0003-9993 (ISSN-L)
- OpenAlex
- W2073121292
- Cited by
- 83
- References
- 70
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 4 · 2019: 5 · 2018: 5 · 2016: 3 · 2015: 9 · 2014: 5 · 2013: 1
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physical Medicine and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Health Research Board (2007/16)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Keywords
- chronic low back pain, sleep disorders, physiotherapy, walking program, actigraphy, Pittsburgh Sleep Quality Index, Insomnia Severity Index, sleep quality, feasibility, recruitment (clinical trials), manual therapy
- MeSH terms
- Adult, Chronic Disease, Feasibility Studies, Female, Humans, Male, Middle Aged, Sleep Wake Disorders, Prevalence, Walking, Low Back Pain, Physical Therapy Modalities, Intention to Treat Analysis
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