Accumbens dopamine mediates the rewarding effect of orosensory stimulation by sucrose
Abstract
To investigate the hypothesis that central dopamine mediates the rewarding effect of orosensory stimulation by sucrose that increases eating, specific dopamine antagonists were administered prior to sham-feeding tests in which rats ingested various concentrations of sucrose. Sham feeding (SF) was used to preserve the orosensory stimulation of sucrose while it eliminated sucrose's postingestive effects. The antagonists decreased intake as a function of the concentration of sucrose. Microstructural analysis of licking demonstrated that the antagonists did not affect the motor performance of licking. Thus, the inhibitory effect of the antagonists on intake was due to a decrease in the rewarding effect of sucrose. Microdialysis experiments demonstrated that dopamine was released in the nucleus accumbens during SF and that the synaptic action of dopamine in the accumbens was necessary for the normal rewarding effect of orosensory stimulation by sucrose.
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When palatable foods such as sucrose are actually consumed, a sustained and sweetness-dependent increase occurs in nucleus accumbens dopamine levels and turnover.
“In addition, when palatable foods such as sucrose are actually consumed, a sustained and sweetness-dependent increase occurs in nucleus accumbens dopamine levels and turnover ([75](#B75), [80](#B80), [165](#B165)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [165]
Cites
Progress in Psychobiology and Physiological Psychology
Fluharty, S. J., & Grill, H. J. (2003) · Progress in psychobiology and physiological psychology · doi:10.1108/s0363-0951200318 · Cited by 1,701 · see citing works
Handbook of behavioral neurobiology
Blass, E. M. (1988) · Plenum Press eBooks · Cited by 1,124 · see citing works
Oral sucrose stimulation increases accumbens dopamine in the rat
Hajnal, A., Smith, G. P., & Norgren, R. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00282.2003 · Cited by 449 · see citing works
Self-citationThe Physiological Mechanisms of Motivation
(1982) · Springer eBooks · doi:10.1007/978-1-4612-5692-2 · Cited by 277 · see citing works
Accumbens dopamine mechanisms in sucrose intake
Hajnal, A. S., & Norgren, R. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02451-9 · Cited by 219 · see citing works
Pimozide decreases the positive reinforcing effect of sham fed sucrose in the rat
Geary, N., & Smith, G. P. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90528-3 · Cited by 156 · see citing works
Self-citationRepeated access to sucrose augments dopamine turnover in the nucleus accumbens
Hajnal, A. S., & Norgren, R. (2002) · Neuroreport · doi:10.1097/00001756-200212030-00010 · Cited by 100 · see citing works
Schneider, L. H., Davis, J. D., Watson, C. A., & Smith, G. P. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)94060-b · Cited by 93 · see citing works
Self-citationOrosensory Self‐Stimulation by Sucrose Involves Brain Dopaminergic Mechanismsa
Schneider, L. H. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb53252.x · Cited by 48 · see citing works
Taste: A Model of Incentive Motivation
Pfaffmann, C. (1982) · Springer eBooks · doi:10.1007/978-1-4612-5692-2_3 · Cited by 47 · see citing works
Pfaffmann, C. (1965) · American Psychologist · doi:10.1037/h0021821 · Cited by 16 · see citing works
Accumbens Dopamine is a Physiological Correlate of the Rewarding and Motivating Effects of Food
Smith, G. P. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48643-1_2 · Cited by 12 · see citing works
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Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
Salamone, J. D., Correa, M., Farrar, A., & Mingote, S. M. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0668-9 · Cited by 1,000 · see citing works
Food reward, hyperphagia, and obesity
Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275 · see citing works
Stress, Overeating, and Obesity: Insights from Human Studies and Preclinical Models
Razzoli, M., Pearson, C., Crow, S., & Bartolomucci, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.026 · Cited by 228 · see citing works
Gustatory reward and the nucleus accumbens
Norgren, R., Hajnal, A., & Mungarndee, S. S. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.024 · Cited by 181 · see citing works
Modulation of taste responsiveness and food preference by obesity and weight loss
Berthoud, H.-R., & Zheng, H. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.04.004 · Cited by 123 · see citing works
Oxytocin action in the ventral tegmental area affects sucrose intake
Mullis, K., Kay, K., & Williams, D. L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.026 · Cited by 122 · see citing works
- Authors
- Smith, G. P.
- Affiliations
- Cornell University (US)
- Corresponding author
- Smith, Gerard P
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 43
- Issue
- 1
- Pages
- 11-13
- ISSN
- 0195-6663 (ISSN-L)
- OpenAlex
- W2067581904
- Cited by
- 87
- References
- 12
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 11
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- nucleus accumbens, dopamine, sucrose, food reward, dopamine antagonists, sham feeding, licking behavior, dietary intake, dopamine release
- MeSH terms
- Animals, Dopamine, Nucleus Accumbens, Receptors, Dopamine, Reward, Sucrose, Microdialysis, Dopamine Antagonists, Feedback, Physiological, Rats
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