CoChat
Sign Up
Cited by 181Neurotransmitter Receptor Influence on BehaviorOlfactory and Sensory Function StudiesBiochemical Analysis and Sensing Techniques

Gustatory reward and the nucleus accumbens

Open access
Norgren, R., Hajnal, A., Mungarndee, S.S.·2006·Physiology & Behavior
DOI 10.1016/j.physbeh.2006.05.024PMC PMC3114426
Open this paper in CoChat — free account

Abstract

The concept of reward is central to psychology, but remains a cipher for neuroscience. Considerable evidence implicates dopamine in the process of reward and much of the data derives from the nucleus accumbens. Gustatory stimuli are widely used for animal studies of reward, but the connections between the taste and reward systems are unknown. In a series of experiments, our laboratory has addressed this issue using functional neurochemistry and neuroanatomy. First, using microdialysis probes, we demonstrated that sapid sucrose releases dopamine in the nucleus accumbens. The effect is dependent on oral stimulation and concentration. We subsequently determined that this response was independent of the thalamocortical gustatory system, but substantially blunted by damage to the parabrachial limbic taste projection. Further experiments using c-fos histochemistry confirmed that the limbic pathway was the prime carrier for the gustatory afferent activity that drives accumbens dopamine release.

Integrity signals

Registry

Crossref · 10.1016/j.physbeh.2006.05.024

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In rodents, first exposure to a food reward increases VTA DA neuron firing and DA release in the NAc.

    “Experiments in rodents have shown that, upon first exposure to a food reward, the firing of DA neurons in the VTA increases with a resulting increase in DA release in NAc (22).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [22]

  • On first exposure to food reward, VTA DA neuron firing increases and DA release in NAc increases.

    “For example, upon first exposure to a food reward, the firing of DA neurons in the VTA increases with a resulting increase in DA release in the NAc (32).”

    From The Addictive Dimensionality of Obesity (2013) · cites this paper as [32]

  • In rodents, upon first exposure to a food reward, the firing of DA neurons in the VTA increases with a resulting increase in DA release in the nucleus accumbens.

    “Experiments in rodents have shown that, upon first exposure to a food reward, the firing of DA neurons in the VTA increases with a resulting increase in DA release in NAc (Norgren et al 2006).”

    From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Norgren et al 2006

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Norgren, R., Hajnal, A., & Mungarndee, S. S.
Affiliations
Pennsylvania State University (US)
Corresponding author
Norgren, R.
ORCID
Hajnal, A.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2006-11
Volume
89
Issue
4
Pages
531-535
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2006.05.024
PMC
PMC3114426
OpenAlex
W2081917843
Cited by
181
References
47
Citations by year
2026: 6 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 16 · 2013: 10 · 2012: 12
FWCI
3.03
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Deafness and Other Communication Disorders (DC 05435, DC 00240, R01DC000240, R01DC005435)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK065709, R01DK065709)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
nucleus accumbens, dopamine release, sucrose, taste system, parabrachial nucleus, c-fos, oral stimulation
MeSH terms
Afferent Pathways, Animals, Association Learning, Dopamine, Limbic System, Mouth, Nucleus Accumbens, Reward, Taste, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review