Modulation of taste responsiveness and food preference by obesity and weight loss
Open accessAbstract
Palatable foods lead to overeating, and it is almost a forgone conclusion that it is also an important contributor to the current obesity epidemic - there is even talk about food addiction. However, the cause-effect relationship between taste and obesity is far from clear. As discussed here, there is substantial evidence for altered taste sensitivity, taste-guided liking and wanting, and neural reward processing in the obese, but it is not clear whether such traits cause obesity or whether obesity secondarily alters these functions. Studies with calorie restriction-induced weight loss and bariatric surgery in humans and animal models suggest that at least some of the obesity-induced alterations are reversible and consequently represent secondary effects of the obese state. Thus, both genetic and non-genetic predisposition and acquired alterations in taste and reward functions appear to work in concert to aggravate palatability-induced hyperphagia. In addition, palatability is typically associated with high energy content, further challenging energy balance regulation. The mechanisms responsible for these alterations induced by the obese state, weight loss, and bariatric surgery, remain largely unexplored. Better understanding would be helpful in designing strategies to promote healthier eating and prevention of obesity and the accompanying chronic disease risks.
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Obesity is associated with decreased responsiveness to sweet and fatty tastes, resulting in needing higher intensity of stimuli to attain same taste perception.
“Interestingly, obesity is associated with a decreased responsiveness to sweet and fatty tastes, which results in needing a higher intensity of such stimuli to attain the same level of taste perception (Berthoud and Zheng, 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Berthoud and Zheng, 2012
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van Dijk, G., & Kas, M. J. (2014) · Cambridge University Press eBooks · doi:10.1017/9781107360556.005 · Cited by 2 · see citing works
Behavioural evaluation of mouse models of type 2 diabetes
Hitchen, B., Norwood, K., Gault, V. A., & Leslie, J. C. (2021) · Learning and Motivation · doi:10.1016/j.lmot.2021.101730 · Cited by 2 · see citing works
Mason, T. B., Tackett, A. P., & Leventhal, A. M. (2023) · Substance Use & Misuse · doi:10.1080/10826084.2023.2294962 · Cited by 1 · see citing works
Changes in perceptions of taste after bariatric surgery: a narrative review
Park, Y. S. (2024) · 한국정맥경장영양학회지 · doi:10.15747/acnm.2024.16.3.120 · Cited by 1 · see citing works
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Adolescents’ Needs Towards School-Based Nutrition Interventions
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Obesity: Peripheral Signals, Neural and Peptidergic
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Fat Mass and Obesity-Related Gene (FTO) and Binge Eating Disorder in Adults and Adolescents
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Obesity: Peripheral Signals, Neural and Peptidergic
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- Authors
- Berthoud, H.-R., & Zheng, H.
- Affiliations
- Pennington Biomedical Research Center (US)
- University of Pittsburgh (US)
- Corresponding author
- Berthoud, Hans-Rudolf
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 107
- Issue
- 4
- Pages
- 527-532
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC3406227
- OpenAlex
- W1978966909
- Cited by
- 123
- References
- 105
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 16 · 2020: 10 · 2019: 13 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 4 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK047348, R01DK071082, DK071082, R01DK047348, P30DK072476)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- taste sensitivity, food preferences, obesity, weight loss, bariatric surgery, caloric restriction, palatability, hyperphagia, food addiction, reward processing, energy balance, genetic susceptibility
- MeSH terms
- Animals, Food Preferences, Humans, Obesity, Reward, Weight Loss, Caloric Restriction, Bariatric Surgery, Taste Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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