Cited by 407Probiotics and Fermented FoodsGut microbiota and healthAntioxidants, Aging, Portulaca oleracea

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Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

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Yang, Xueqin, Yu, Dongke, Xue, Li, Li, Hui, Du, Junrong·2020·Acta Pharmaceutica Sinica B

DOI 10.1016/j.apsb.2019.07.001PMC PMC7049608

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Abstract

ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis , Lactobacillus casei , Bifidobacterium bifidum , and Lactobacillus acidophilus . This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits , and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits , cerebral neuronal and synaptic injuries , glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood–brain barrier, decreased interleukin-6 and tumor necrosis factor- α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor- κ B (NF- κ B) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ -H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF- κ B signaling pathway and inflammatory responses.

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Background
Frequent fecal microbiota transplantation improves cognitive impairment and pathological changes in Alzheimer's disease FAD4T mice via the microbiota-gut-brain axis
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Fraxetin attenuates DNA damage and inflammation in cisplatin-induced nephrotoxicity via FoxO1 activation
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Wang, Y., Wang, C., Yang, X., Ni, K., Jiang, L., Li, X., Liu, Q., Xu, X., Gu, X., Liu, Y., et al. (2023) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006705 · Cited by 4
Self-citation
Probiotics combination effectively improves constipation in pregnancy by modifying the gut microbiota composition
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Proteomic analysis and experimental validation reveal the blood–brain barrier protective of Huanshaodan in the treatment of SAMP8 mouse model of Alzheimer’s disease
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Background
Effects of probiotics on cognitive and emotional functions in healthy older adults: Protocol for a double‐blind randomized placebo‐controlled crossover trial
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Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways
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Background
Can the Therapeutic Spectrum of Probiotics be Extended: Exploring Potential of Gut Microbiome
Rastogi, S., Singh, A., Nandi, A., Gupta, A., Agarwal, J., & Kostova, I. P. (2022) · Recent Advances in Anti-Infective Drug Discovery · doi:10.2174/2772434418666221124124317 · Cited by 4
Animal Models of Cognitive Deficits for Probiotic Treatment
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“LPS can also be 182 administered directly to brain tissue via ICV injection (Kamdi et al., 2021; Shoemark 183 and Allen, 2015; Yang et al., 2020a).”
BackgroundMethodInfluential
High-amylose diet ameliorates LPS-induced cognitive impairment and depression-like phenotype
Takura, K., Wei, R., Takayanagi, R., Sakai, Y., Hattori, M., & Ohshima, T. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138295 · Cited by 3
“Probiotic supplementation with Bifidobacterium and Lactobacillus improved memory deficits in mice [52], and a double-blind placebo-controlled clinical trial demonstrated the therapeutic effects of probiotic treatment with Bifidobacterium on cognitive function and mood [53].”

Authors: Yang, X., Yu, D., Xue, L., Li, H., & Du, J.
Affiliations: Sichuan University (CN)
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Corresponding author: Du, Junrong
ORCID: Yang, Xueqin
Yu, Dongke
Li, Hui
Du, Junrong
Venue: Acta Pharmaceutica Sinica B
Publisher: Elsevier BV
Published: 2020-03
Volume: 10
Issue: 3
Pages: 475-487
ISSN: 2211-3835 (ISSN-L)
DOI: 10.1016/j.apsb.2019.07.001
PMC: PMC7049608
OpenAlex: W2954864461
Cited by: 407
References: 54
Citations by year: 2026: 45 · 2025: 82 · 2024: 91 · 2023: 69 · 2022: 65 · 2021: 41 · 2020: 14
FWCI: 23.15
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81473219, 81973307)
Sichuan Province Youth Science and Technology Innovation Team (2016TD0001)
Higher Education Discipline Innovation Project
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: probiotics, microbiota-gut-brain axis, memory impairment, aging, SAMP8 mice, Bifidobacterium animalis subsp. lactis, Lactobacillus casei, Lactobacillus acidophilus, Bifidobacterium bifidum, neuroinflammation, blood-brain barrier, intestinal barrier, lipopolysaccharide, TLR4, NF-κB signaling, RIG-I, oxidative stress, cognitive function

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Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

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