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Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice
Open accessAbstract
ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis , Lactobacillus casei , Bifidobacterium bifidum , and Lactobacillus acidophilus . This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits , and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits , cerebral neuronal and synaptic injuries , glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood–brain barrier, decreased interleukin-6 and tumor necrosis factor- α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor- κ B (NF- κ B) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ -H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF- κ B signaling pathway and inflammatory responses.
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“Probiotic-4 (which contains Lactobacillus, Bifidobacterium, Typhimurium, and Eosinophilus) has been shown to attenuate aging-related disruptions in the integrity of the blood–brain barrier and the intestinal barrier; in plasma and brain LPS levels; and in IL-6, TNF-α, TLR4, and NF-κB translocation in the brains of aged mice (104).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [104]
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Background
Metadata
- Authors
- Yang, X., Yu, D., Xue, L., Li, H., & Du, J.
- Affiliations
- Sichuan University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Corresponding author
- Du, Junrong
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 10
- Issue
- 3
- Pages
- 475-487
- ISSN
- 2211-3835 (ISSN-L)
- PMC
- PMC7049608
- OpenAlex
- W2954864461
- Cited by
- 407
- References
- 54
- Citations by year
- 2026: 45 · 2025: 82 · 2024: 91 · 2023: 69 · 2022: 65 · 2021: 41 · 2020: 14
- FWCI
- 23.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81473219, 81973307)
- Sichuan Province Youth Science and Technology Innovation Team (2016TD0001)
- Higher Education Discipline Innovation Project
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- probiotics, microbiota-gut-brain axis, memory impairment, aging, SAMP8 mice, Bifidobacterium animalis subsp. lactis, Lactobacillus casei, Lactobacillus acidophilus, Bifidobacterium bifidum, neuroinflammation, blood-brain barrier, intestinal barrier, lipopolysaccharide, TLR4, NF-κB signaling, RIG-I, oxidative stress, cognitive function
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