Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence
Abstract
Recent studies have suggested the role of an infectious component in the pathogenesis of Alzheimer's disease (AD). In light of this, research has focused on some bacteria constituting the intestinal microbial flora which can produce amyloid. Once generated, the latter hypothetically triggers a systemic inflammatory response which compromises complex brain functions, such as learning and memory. Clinical studies have shown that, in cognitively impaired elderly patients with brain amyloidosis, there is lower abundance in the gut of E. rectale and B. fragilis, two bacterial species which have an anti-inflammatory activity, versus a greater amount of pro-inflammatory genera such as Escherichia/Shigella. According to these findings, some clinical studies have demonstrated that supplementation with Lactobacilli- and Bifidobacteria- based probiotics has improved cognitive, sensory and emotional functions in subjects with AD. Moreover, certain herbal products, in particular dietetic polyphenols, have proved capable of restoring dysbiosis and, therefore, their prebiotic role could be effective in counteracting the onset of AD regardless of their activity of free radical scavenging or enhancement of the cell stress response. One of the recent greatest novelties in the field of neurodegenerative diseases is the chance to prevent or slow down AD progression with agents, such as probiotics and prebiotics, acting outside the central nervous system.
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In the stools of patients with AD, the abundance of pro-inflammatory bacteria (Escherichia/Shigella) increases and the abundance of anti-inflammatory bacteria (Eubacterium rectale) and Bacteroides fragilis decreases.
“In the stools of patients with AD, the abundance of pro-inflammatory bacteria (Escherichia/Shigella) increases and the abundance of anti-inflammatory bacteria (Eubacterium rectale) and Bacteroides fragilis decreases (Mancuso and Santangelo 2018).”
From Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease (2020) · cites this paper as Mancuso and Santangelo 2018
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TREM2 signaling, miRNA-34a and the extinction of phagocytosis
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Biotic/Abiotic Stress-Driven Alzheimer's Disease
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Title: Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiotaPreprint
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Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs
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Self-citationConnections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis
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Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiotaPreprint
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Brain-Gut-Microbiota Axis in Alzheimer’s Disease
Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826 · see citing works
“pathogenesis of AD and the close association between gut dysbiosis, increased intestinal permeability, and neurological dysfunction creates opportunity for potential therapeutic interventions.(108) The results of numerous studies confirm the beneficial effect of probiotics”
BackgroundLiu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669 · see citing works
“…been reported in AD transgenic mice model (Zhang et al., 2017a), and the depletion of Ruminococcus could lead to the compromised intestinal permeability, which thus facilitated the gut amyloid transferred to the systemic circulation and then accumulated in the brain (Mancuso and Santangelo, 2017).”
Role and Mechanism of Gut Microbiota in Human Disease
Chen, Y., Zhou, J., & Wang, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625913 · Cited by 643 · see citing works
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
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Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease
Kesika, P., Suganthy, N., Sivamaruthi, B. S., & Chaiyasut, C. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118627 · Cited by 479 · see citing works
Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice
Yang, X., Yu, D., Xue, L., Li, H., & Du, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.07.001 · Cited by 407 · see citing works
Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota
Shabbir, U., Rubab, M., Daliri, E. B., Chelliah, R., Javed, A., & Oh, D. (2021) · Nutrients · doi:10.3390/nu13010206 · Cited by 338 · see citing works
“While during weaning, Bacteroidetes and Firmicutes compositions seem to increase with the decrease in Proteobacteria and Actinobacteria compositions, conversely, in elders, Bacteroidetes and Proteobacteria tend to upsurge [42].”
BackgroundThe Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
“symbiotically and pathogenically in our body [5] and plays a vital role in regulatory func-”
BackgroundSun, J., Xu, J., Yang, B., Chen, K., Kong, Y., Fang, N., Gong, T., Wang, F., Ling, Z., & Liu, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900636 · Cited by 302 · see citing works
Zhang, J., Sun, Z., Jiang, S., Bai, X., Ma, C., Peng, Q., Chen, K., Chang, H., Fang, T., & Zhang, H. (2019) · mSystems · doi:10.1128/msystems.00017-19 · Cited by 283 · see citing works
“Emerging evidence indicates that there is a close relationship between the intestinal microbiota and various chronic metabolic diseases, including type 2 diabetes (2), liver cirrhosis (3), gout (4), colorectal cancer (5), arthritis (6), and even brain disorders such as Alzheimer’s disease (7, 8) and Parkinson’s diseas…”
BackgroundPellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270 · see citing works
“In particular, it has been postulated that changes in gut microbiota composition can promote enteric β amyloid (Aβ) protein accumulation (a hallmark of AD), which, in turn, could shape enteric and peripheral neurogenic/inflammatory responses and contribute to neuroinflammation and neurodegeneration in the CNS [56].”
BackgroundGut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis
Liang, S., Wu, X., & Jin, F. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00033 · Cited by 269 · see citing works
“, 2016; Liddle, 2018); aberrations first appear in the gut microbiota and gut (Li W. et al., 2017; Mancuso and Santangelo, 2017), with ENS degeneration occurring first and gradually spreading to the CNS, while improving gut-brain function by adjusting the microbiota has remedial effects (Hu et al.”
BackgroundThe Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225 · see citing works
“Extrinsic factors including diet, lifestyle, or also pro-inflammatory insults, along with intrinsic components including genetic polymorphism, immunity, metabolites, and hormones, profoundly affect the composition of the gut microflora, which in turn produces signaling molecules such as short chain fatty acids (SCFAs)…”
BackgroundGut microbiota, cognitive frailty and dementia in older individuals: A systematic review
Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215 · see citing works
“prehensive profiling of gut microbiota composition and functionality.(89)”
BackgroundChen, Y.-H., Bai, J., Wu, D., Yu, S.-F., Qiang, X.-L., Bai, H., Wang, H., & Peng, Z. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.014 · Cited by 225 · see citing works
Gut microbiota in patients with Alzheimer’s disease spectrum: a systematic review and meta-analysis
Hung, C.-C., Chang, C., Huang, C.-W., Nouchi, R., & Cheng, C. (2022) · Aging · doi:10.18632/aging.203826 · Cited by 217 · see citing works
“It has also been reported that probiotics with Bifidobacterium ameliorated cognitive impairments in patients with AD [68].”
BackgroundShen, H., Guan, Q., Zhang, X., Yuan, C., Tan, Z., Zhai, L., Hao, Y., Gu, Y., & Han, C. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109884 · Cited by 204 · see citing works
Disorders of the enteric nervous system — a holistic view
Niesler, B., Küerten, S., Demir, İ. E., & Schäfer, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00385-2 · Cited by 198 · see citing works
Microbiota-gut brain axis involvement in neuropsychiatric disorders
Iannone, L. F., Preda, A., Blottière, H. M., Clarke, G., Albani, D., Belcastro, V., Carotenuto, M., Cattaneo, A., Citraro, R., Ferraris, C., et al. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1638763 · Cited by 177 · see citing works
“, [127]; Mancuso and Santangelo, [11] Autism spectrum disorders Liu et al.”
BackgroundAbnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice
Zhan, G., Yang, N., Li, S., Huang, N., Fang, X., Zhang, J., Zhu, B., Yang, L., Yang, C., & Luo, A. (2018) · Aging · doi:10.18632/aging.101464 · Cited by 176 · see citing works
“Recently, several studies have suggested significant interactions between alterations of the gut microbiota and cognitive behavior [15, 16].”
BackgroundLai, F., Jiang, R., Xie, W., Liu, X., Tang, Y., Xiao, H., Gao, J., Jia, Y., & Bai, Q. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2620-x · Cited by 169 · see citing works
New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis
Liu, Y.-W., Liong, M., & Tsai, Y.-C. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8079-2 · Cited by 152 · see citing works
Xu, M., Mo, X., Huang, H., Chen, X., Liu, H., Peng, Z., Chen, L., Rong, S., Yang, W. Q., Xu, S., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.180 · Cited by 137 · see citing works
Sun, Z., Li, X., Wang, S., Shen, L., & Ji, H. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10461-x · Cited by 137 · see citing works
The Relationship Between the Gut Microbiome and Neurodegenerative Diseases
Zhu, X., Li, B., Lou, P., Dai, T., Chen, Y., Zhuge, A., Yuan, Y., & Li, L. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00730-8 · Cited by 134 · see citing works
“Some clinical trials have revealed the effectiveness of probiotics in regulating gut microbiota disorders, and in preventing or inhibiting cognitive or emotional disorders, suggesting the potential of probiotics for the treatment of AD [20, 74].”
BackgroundDYRK1A inhibitors for disease therapy: Current status and perspectives
Liu, T., Wang, Y., Wang, J., Ren, C., Chen, H., & Zhang, J. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.114062 · Cited by 126 · see citing works
Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment
Wei, S., Peng, W., Mai, Y., Li, K., Wei, W., Hu, L., Zhu, S., Zhou, H., Jie, W., Wei, Z., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29362 · Cited by 122 · see citing works
“We (Jiang, Li, Huang, Liu, & Zhao, 2017) and others (Alkasir, Li, Li, Jin, & Zhu, 2017; Hu, Wang, & Jin, 2016; Mancuso & Santangelo, 2018; Pistollato et al., 2016; Quigley, 2017; Zhang et al., 2017) have proposed that the trigger for pathogenic factors in AD patients is the GM. OMVs derived from…”
Ginsenosides, catechins, quercetin and gut microbiota: Current evidence of challenging interactions
Santangelo, R., Silvestrini, A., & Mancuso, C. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.10.042 · Cited by 121 · see citing works
Self-citationIndoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease
Pappolla, M. A., Perry, G. L., Fang, X., Zagorski, M. G., Sambamurti, K., & Pöeggeler, B. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105403 · Cited by 122 · see citing works
“, 2014) including the development of neurodegenerative disease.(Chyan et al., 1999; Naseer et al., 2014; Mayer et al., 2015; Mancuso and Santangelo, 2018) The identities of the bacterial molecules mediating multiple effects of the microbiota in the brain began to be defined in the last two decades.”
BackgroundChiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis
Guo, X. L., Li, C., Zhang, J., Sun, M., Xu, J., Xu, C., Kuang, H., & Xu, L. (2023) · Nature Aging · doi:10.1038/s43587-023-00516-9 · Cited by 110 · see citing works
“The long-distance interaction between the gut microbiota and neurodegeneration may provide a theoretical foundation for treating those diseases 21–23 .”
BackgroundDelivery routes for faecal microbiota transplants: Available, anticipated and aspired
Gulati, M., Singh, S. K., Corrie, L., Kaur, I. P., & Chandwani, L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104954 · Cited by 112 · see citing works
Probiotics for dementia: a systematic review and meta-analysis of randomized controlled trials
Krüger, J. F., Hillesheim, E., Pereira, A. C. D. S. N., Camargo, C. D. Q., & Rabito, E. I. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa037 · Cited by 109 · see citing works
Zhao, N., Chen, Q.-G., Chen, X., Liu, X.-T., Geng, F., Zhu, M.-M., Yan, F.-L., Zhang, Z.-J., & Ren, Q.-G. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.11.013 · Cited by 105 · see citing works
Dietary Pattern, Gut Microbiota, and Alzheimer’s Disease
Zhang, M., Zhao, D., Zhou, G., & Li, C. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b08309 · Cited by 106 · see citing works
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing
Fang, J., Pieper, A. A., Nussinov, R., Lee, G., Bekris, L. M., Leverenz, J. B., Cummings, J. L., & Cheng, F. (2020) · Medicinal Research Reviews · doi:10.1002/med.21709 · Cited by 93 · see citing works
Of microbes and minds: A narrative review on the second brain aging
Calvani, R., Picca, A., Lo Monaco, M. R., Landi, F., Bernabei, R., & Marzetti, E. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00053 · Cited by 92 · see citing works
“Preclinical studies have suggested the efficacy of the modulation of the gut microbiota in ameliorating conditions such as depression and neurodegenerative diseases (150).”
BackgroundInteractions between central nervous system and peripheral metabolic organs
Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 96 · see citing works
“Specifically, the proinflammatory species Escherichia and Shigella were increased in AD, while the antiinflammatory species Eubacterium rectale and Bacteroides fragilis were decreased (Mancuso and Santangelo, 2018).”
BackgroundTherapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective
Aponte, M., Murru, N., & Shoukat, M. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.562048 · Cited by 92 · see citing works
Microbiota-gut-brain axis and toll-like receptors in Alzheimer’s disease
Lin, C., Zhao, S., Zhu, Y., Fan, Z., Wang, J., Zhang, B., & Chen, Y. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.008 · Cited by 91 · see citing works
“Administration of probiotics appears to be a novel and safe method to preserve a healthy intestinal microbiota and intestinal barrier, reducing the initiation of pro-inflammatory responses and propagation of neuroinflammation in neurodegeneration diseases [125].”
BackgroundMethodTang, W., Meng, Z., Li, N., Liu, Y., Li, L., Chen, D., & Yang, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.611014 · Cited by 89 · see citing works
Chu, C., Yu, L., Qi, G., Mi, Y., Wu, W., Lee, Y. K., Zhai, Q., Tian, F., & Chen, W. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104556 · Cited by 85 · see citing works
Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease
Wu, L., Xian, X., Xu, G., Tan, Z., Dong, F., Zhang, M., & Zhang, F. (2022) · Mediators of Inflammation · doi:10.1155/2022/7924199 · Cited by 85 · see citing works
“Probiotics offer a potential preventive effect on AD progression [150, 151].”
BackgroundGut Microbiota: Implications in Alzheimer’s Disease
He, Y., Li, B., Sun, D., & Chen, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072042 · Cited by 81 · see citing works
The intestinal microbiome and its relevance for functionality in older persons
Ticinesi, A., Tana, C., & Nouvenne, A. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000521 · Cited by 80 · see citing works
Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s Disease
Zhu, G., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.005 · Cited by 75 · see citing works
“In addition, another review summarized preclinical and clinical studies and reported that the alterations in the microbiome composition can trigger Aβ accumulation [50].”
BackgroundGut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s disease
Li, Z., Zhu, H., Guo, Y., Du, X., & Qin, C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15031 · Cited by 73 · see citing works
“…microbial dysbiosis and AD is not yet fully understood, yet a number of studies have shown that gut microbiota of AD patients and AD mouse models were different from those of healthy controls (Hoffman et al., 2017; Mahmoudian Dehkordi et al. 2019; Mancuso & Santangelo, 2018; Shen, Liu, & Ji, 2017).”
BackgroundGut Microbiota in Neurological Disorders
Grochowska, M., Laskus, T., & Radkowski, M. (2019) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-019-00561-6 · Cited by 72 · see citing works
Fang, X., Zhou, X., Miao, Y., Han, Y., Wei, J., & Chen, T. (2020) · AMB Express · doi:10.1186/s13568-020-01014-6 · Cited by 70 · see citing works
Aragón-González, A., Shaw, P. J., & Ferraiuolo, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315271 · Cited by 72 · see citing works
Zou, B., Li, J., Ma, R., Cheng, X.-Y., Ma, R.-Y., Zhou, T.-Y., Wu, Z., Yao, Y., & Li, J. (2023) · Aging and Disease · doi:10.14336/ad.2022.1127 · Cited by 69 · see citing works
“Phylum Bacteroidetes, Proteobacteria Firmicutes, Verrucomicrobia, Actinobacteria [54, 136, 147, 148]”
BackgroundCrosstalk Between the Gut Microbiota and the Brain: An Update on Neuroimaging Findings
Liu, P., Peng, G., Zhang, N., Wang, B., & Luo, B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00883 · Cited by 69 · see citing works
Go, J., Chang, D., Ryu, Y., Park, H., Lee, I.-B., Noh, J., Hwang, D. Y., Kim, B., Kim, K., & Lee, C. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.12.010 · Cited by 67 · see citing works
Zhu, H., Hao, H., & Yu, L. (2023) · BMC Biology · doi:10.1186/s12915-023-01796-8 · Cited by 66 · see citing works
“The diseases we focused on include Alzheimer’s disease [34], Crohn’s disease [36], and colo-rectal neoplasms [37].”
BackgroundMetaproteomics of the human gut microbiota: Challenges and contributions to other OMICS
Isaac, N. I., Decloquement, P., Armstrong, N., Raoult, D., & Chabrière, É. (2019) · Clinical mass spectrometry · doi:10.1016/j.clinms.2019.06.001 · Cited by 65 · see citing works
Zhang, M., Zhang, M., Kou, G., & Li, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1159771 · Cited by 63 · see citing works
“In contrast, the abundance of intestinal flora with pro-inflammatory is higher (Mancuso and Santangelo, 2018).”
BackgroundFunctional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease
Atlante, A., Amadoro, G., Bobba, A., & Latina, V. (2020) · Cells · doi:10.3390/cells9112347 · Cited by 64 · see citing works
What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review
Bonnechère, B., Amin, N., & van Duijn, C. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213665 · Cited by 64 · see citing works
“AD [32], PD [33], MS [34], and ALS [35].”
BackgroundNovel targets in Alzheimer’s disease: A special focus on microglia
Balducci, C., & Forloni, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.017 · Cited by 61 · see citing works
Li, Y., Wang, Y., Shi, F., Zhang, X., Zhang, Y., Bi, K., Chen, X., Li, L., & Diao, H. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096994 · Cited by 60 · see citing works
“Previous studies have shown that Alzheimer’s disease is positively correlated with Shigella or trimethylamine oxide in the intestine.(37,38) In addition, coronavirus disease 2019 is related to the impaired synthesis of bacterial metabolites such as short-chain fatty acids or L-isoleucine.”
ResultSleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Phan, T., & Malkani, R. G. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.001 · Cited by 64 · see citing works
“Comprehensive reviews of the gut-microbiota are covered in these articles (Mancuso and Santangelo, 2018; de la Fuente-Nunez et al., 2018; Zhang et al., 2017).”
Zhu, H., Hao, H., & Yu, L. (2024) · BMC Biology · doi:10.1186/s12915-024-01968-0 · Cited by 57 · see citing works
“The diseases examined in this section are colorectal neoplasms [41], Alzheimer’s disease [40], and Crohn’s disease [42].”
BackgroundEpigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health
Covarrubias, D. G., Ramírez‐Díaz, I., Guzmán-Linares, J., Limón, I. D., Manuel-Sánchez, D. M., Molina-Herrera, A., Coral-García, M. Á., Anastasio, E., Anaya‐Hernández, A., López‐Salazar, P., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2023.1306600 · Cited by 62 · see citing works
Mohammadi, G., Dargahi, L., Naserpour, T., Mirzanejad, Y., Alizadeh, S. A., Peymani, A., & Nassiri‐Asl, M. (2018) · International Microbiology · doi:10.1007/s10123-018-00051-3 · Cited by 54 · see citing works
“It represents the more importance of targeted gut microbiota manipulation in management of these complicated disorders such as Alzheimer’s disease (AD) (Pistollato et al. 2016; Mancuso and Santangelo 2018).”
BackgroundRecent advances in understanding the mechanisms of PM2.5-mediated neurodegenerative diseases
Zhu, X., Ji, X., Shou, Y., Huang, Y., Hu, Y., & Wang, H. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.04.017 · Cited by 54 · see citing works
Ramulus mori polysaccharide-loaded PLGA nanoparticles and their anti-inflammatory effects in vivo
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Implications of Gut Microbiota in Complex Human Diseases
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“Approximately, there will be 66 million AD patients worldwide by 2030 and up to 115 million by 2050 [5].”
- Authors
- Mancuso, C., & Santangelo, R.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Mancuso, Cesare
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 129
- Pages
- 329-336
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2774851697
- Cited by
- 232
- References
- 108
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 30 · 2023: 25 · 2022: 29 · 2021: 27 · 2020: 28 · 2019: 23 · 2018: 20
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Catholic University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Alzheimer's disease, gut microbiota, gut-brain axis, amyloid, Bacteroides fragilis, lactobacilli, Bifidobacterium, probiotics, prebiotics, polyphenols, dysbiosis, neuroinflammation, cognitive impairment, neurodegeneration
- MeSH terms
- Gastrointestinal Microbiome, Aging, Alzheimer Disease, Animals, Humans
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