Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules

Gardner, Joanne K.; Mamotte, Cyril D.S.; Jackaman, Connie; Nelson, Delia J.

doi:10.1016/j.arr.2017.07.002

Cited by 40Immunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules

Gardner, Joanne K., Mamotte, Cyril D.S., Jackaman, Connie, Nelson, Delia J.·2017·Ageing Research Reviews

DOI 10.1016/j.arr.2017.07.002

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Abstract

Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients.

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Functions of dendritic cells such as antigen presentation, endocytosis, and IFN production are reduced in aged individuals.
“Moreover, their functions such as antigen presentation, endocytosis, and IFN production, are also reduced in aged individuals [145, 146].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [146]

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Authors: Gardner, J. K., Mamotte, C. D. S., Jackaman, C., & Nelson, D. J.
Affiliations: Curtin University (AU)
Corresponding author: Nelson, Delia J.
ORCID: Gardner, Joanne K.
Mamotte, Cyril D.S.
Jackaman, Connie
Nelson, Delia J.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2017-09
Volume: 38
Pages: 40-51
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2017.07.002
OpenAlex: W2736519944
Cited by: 40
References: 178
Citations by year: 2026: 2 · 2025: 6 · 2024: 10 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2
FWCI: 0.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
eSpace (Curtin University) (submittedVersion)
Funders: Curtin University of Technology
Curtin Health Innovation Research Institute, Curtin University
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: dendritic cells, T cells, immunosenescence, aging, cancer immunotherapy, immune checkpoint inhibitors, antitumor immunity, elderly cancer patients
MeSH terms: Aging, Dendritic Cells, Humans, Neoplasms, T-Lymphocytes, Receptor Cross-Talk

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Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules

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