Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
DeBalsi, Karen L., Hoff, Kirsten E., Copeland, William C.·2017·Ageing Research Reviews
Cites (276)
Items 201–273 of 273
- Overexpression of Tfam protects mitochondria against β‐amyloid‐induced oxidative damage in SH‐SY5Y cellsShangcheng Xu, Min Zhong, Lei Zhang, Yuan Wang, Zhou Zhou, Yutong Hao, Wenyan Zhang, Xuesen Yang, Aimin Wei, Liping Pei et al. · 2009 · FEBS Journal
- Mosaic deficiency in mitochondrial oxidative metabolism promotes cardiac arrhythmia during agingBaris, Olivier R., Ederer, Stefan, Neuhaus, Johannes F.G., von Kleist-Retzow, Jürgen-Christoph, Wunderlich, Claudia M., Pal, Martin, Wunderlich, F. Thomas, Peeva, Viktoriya, Zsurka, Gabor, Kunz, Wolfram S. et al. · 2015 · Cell Metabolism
- Mutation of the Linker Region of the Polymerase γ-1 (POLG1Gene Associated With Progressive External Ophthalmoplegia and ParkinsonismGavin Hudson, Andrew M. Schaefer, Robert William Taylor, Watcharee Tiangyou, Andrew Gibson, Graham S Venables, Philip G. Griffiths, David John Burn, Douglass M. Turnbull, Patrick Francis Chinnery · 2007 · Archives of Neurology
- Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic <i>Drosophila</i>Bayne, Anne-Cécile V., Mockett, Robin J., Orr, William C., Sohal, Rajindar S. · 2005 · Biochemical Journal
- The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal MuscleElena Barbieri, Deborah Agostini, Emanuela Polidori, Lucia Potenza, Michele Guescini, Francesco Lucertini, Giosuè Annibalini, Laura Stocchi, Mauro De Santi, Vilberto Stocchi · 2015 · Oxidative Medicine and Cellular Longevity
- Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonucleaseNicholls, Thomas J., Zsurka, Gábor, Peeva, Viktoriya, Schöler, Susanne, Szczesny, Roman J., Cysewski, Dominik, Reyes, Aurelio, Kornblum, Cornelia, Sciacco, Monica, Moggio, Maurizio et al. · 2014 · Human Molecular Genetics
- Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceHumble, Margaret M., Young, Matthew J., Foley, Julie F., Pandiri, Arun R., Travlos, Greg S., Copeland, William C. · 2013 · Human Molecular Genetics
- Mitochondrial function and mitochondrial DNA maintenance with advancing ageGaziev, Azhub I., Abdullaev, Serzh, Podlutsky, Andrej · 2014 · Biogerontology
- Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytesSuarez, Jorge, Hu, Yong, Makino, Ayako, Fricovsky, Eduardo, Wang, Hong, Dillmann, Wolfgang H. · 2008 · American Journal of Physiology-Cell Physiology
- Somatic mtDNA variation is an important component of Parkinson's diseaseJonathan M Coxhead, Marzena Kurzawa‐Akanbi, Rafiqul Hussain, Angela Pyle, Patrick Francis Chinnery, Gavin Hudson · 2015 · Neurobiology of Aging
- Mitochondrial Nucleoid and Transcription Factor ATomotake Kanki, Hiroshi Nakayama, Narie Sasaki, Koji Takio, Tanfis I. Alam, Naotaka Hamasaki, Dongchon Kang · 2004 · Springer eBooks
- p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exerciseAyesha Saleem, Heather N. Carter, David Albert Hood · 2013 · American Journal of Physiology-Cell Physiology
- Mitochondrial nucleoid and transcription factor AKANKI, TOMOTAKE, NAKAYAMA, HIROSHI, SASAKI, NARIE, TAKIO, KOJI, ALAM, TANFIS ISTIAQ, HAMASAKI, NAOTAKA, KANG, DONGCHON · 2004 · Annals of the New York Academy of Sciences
- Structure–Function Defects of the TWINKLE Linker Region in Progressive External OphthalmoplegiaJenny A. Korhonen, Vineet Pande, Teresa Holmlund, Géraldine Farge, Xuan Hoi Pham, Lennart Nilsson, Maria Falkenberg · 2008 · Journal of Molecular Biology
- Targeted enrichment and high‐resolution digital profiling of mitochondrial
<scp>DNA</scp>
deletions in human brainTaylor, Sean D., Ericson, Nolan G., Burton, Joshua N., Prolla, Tomas A., Silber, John R., Shendure, Jay, Bielas, Jason H. · 2014 · Aging Cell
- Biochemical analysis of human POLG2 variants associated with mitochondrial diseaseYoung, Matthew J., Longley, Matthew J., Li, Fang-Yuan, Kasiviswanathan, Rajesh, Wong, Lee-Jun, Copeland, William C. · 2011 · Human Molecular Genetics
- Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicaseSen, Doyel, Nandakumar, Divya, Tang, Guo-Qing, Patel, Smita S. · 2012 · Journal of Biological Chemistry
- The accessory subunit B of DNA polymerase is required for mitochondrial replisome functionFarge, G., Pham, X. H., Holmlund, T., Khorostov, I., Falkenberg, M. · 2007 · Nucleic Acids Research
- Extension of mouse lifespan by overexpression of catalaseSamuel E. Schriner, Nancy J. Linford · 2006 · AGE
- The mtDNA mutator mouse: Dissecting mitochondrial involvement in agingDaniel Edgar, Aleksandra Trifunović · 2009 · Aging
- Autosomal dominant progressive external ophthalmoplegia: Distribution of multiple mitochondrial DNA deletionsMoslemi, Ali-Reza, Melberg, Atle, Holme, Elisabeth, Oldfors, Anders · 1999 · Neurology
- Evidence for polymerase gamma, POLG1 variation in reduced mitochondrial DNA copy number in Parkinson's diseaseGui, Ya-Xing, Xu, Zhong-Ping, Lv, Wen, Zhao, Jin-Jia, Hu, Xing-Yue · 2015 · Parkinsonism & Related Disorders
- Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.Tarnopolsky, M. A. · 2009 · Applied Physiology Nutrition and Metabolism
- Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expressionShilpa Iyer, Ravindar R. Thomas, Francisco R. Portell, Lisa D. Dunham, Caitlin K. Quigley, James P. Bennett · 2009 · Mitochondrion
- Involvement of Redox State in the Aging of
<i>Drosophila melanogaster</i>Orr, William C., Radyuk, Svetlana N., Sohal, Rajindar S. · 2013 · Antioxidants & Redox Signaling
- Human RNase H1 Is Associated with Protein P32 and Is Involved in Mitochondrial Pre-rRNA ProcessingHongjiang Wu, Hong Sun, Xue‐hai Liang, Walt F. Lima, Stanley T. Crooke · 2013 · PLoS ONE
- Progressive External Ophthalmoplegia Characterized by Multiple Deletions of Mitochondrial DNA: Unraveling the Pathogenesis of Human Mitochondrial DNA Instability and the Initiation of a Genetic ClassificationGert Van Goethem, Jean‐Jacques Martin, Christine Van Broeckhoven · 2003 · NeuroMolecular Medicine
- The systems biology of mitochondrial fission and fusion and implications for disease and agingChauhan, Anuradha, Vera, Julio, Wolkenhauer, Olaf · 2014 · Biogerontology
- Disease Variants of the Human Mitochondrial DNA Helicase Encoded by C10orf2 Differentially Alter Protein Stability, Nucleotide Hydrolysis, and Helicase ActivityMatthew J. Longley, Margaret M. Humble, Farida S. Sharief, William C. Copeland · 2010 · Journal of Biological Chemistry
- Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy numberPohjoismäki, Jaakko L. O., Goffart, Steffi, Taylor, Robert W., Turnbull, Douglas M., Suomalainen, Anu, Jacobs, Howard T., Karhunen, Pekka J. · 2010 · PLoS ONE
- Mitochondrial functional complementation in mitochondrial DNA-based diseasesKazuto Nakada, Akitsugu Sato, Jun‐Ichi Hayashi · 2009 · The International Journal of Biochemistry & Cell Biology
- POLG1 in idiopathic Parkinson diseaseTiangyou, W., Hudson, G., Ghezzi, D., Ferrari, G., Zeviani, M., Burn, D. J., Chinnery, P. F. · 2006 · Neurology
- Development of Mitochondrial Gene Replacement TherapyShaharyar M. Khan, James P. Bennett · 2004 · Journal of Bioenergetics and Biomembranes
- Mitochondrial DNA mutations activate programmed cell survival in the mouse heartZhang, Dekui, Mott, Justin L., Chang, Shin-Wen, Stevens, Melissa, Mikolajczak, Peter, Zassenhaus, H. Peter · 2005 · American Journal of Physiology-Heart and Circulatory Physiology
- Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's diseaseBelin, Andrea Carmine, Björk, Behnosh F., Westerlund, Marie, Galter, Dagmar, Sydow, Olof, Lind, Charlotta, Pernold, Karin, Rosvall, Lina, Håkansson, Anna, Winblad, Bengt et al. · 2007 · Neuroscience Letters
- Mitochondrial dynamics in aging and diseaseBereiter-Hahn, Jürgen · 2014 · Progress in molecular biology and translational science
- Short- and long-term effects of endurance training in patients with mitochondrial myopathyJeppesen, T. D., Dunø, M., Schwartz, M., Krag, T., Rafiq, J., Wibrand, F., Vissing, J. · 2009 · European Journal of Neurology
- Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model systemNishiyama, Satoshi, Shitara, Hiroshi, Nakada, Kazuto, Ono, Tomio, Sato, Akitsugu, Suzuki, Hidenori, Ogawa, Tetsuhiro, Masaki, Haruhiko, Hayashi, Jun-Ichi, Yonekawa, Hiromichi · 2010 · Biochemical and Biophysical Research Communications
- Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levelsRoman J. Szczęsny, Monika S. Hejnowicz, Kamil Steczkiewicz, Anna Muszewska, Lukasz S. Borowski, Krzysztof Ginalski, Andrzej Dziembowski · 2013 · Nucleic Acids Research
- Overexpression of twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen speciesPohjoismäki, Jaakko L. O., Williams, Siôn L., Boettger, Thomas, Goffart, Steffi, Kim, Johnny, Suomalainen, Anu, Moraes, Carlos T., Braun, Thomas · 2013 · Proceedings of the National Academy of Sciences
- Measurement of the 4,834‐bp Mitochondrial DNA Deletion Level in Aging Rat Liver and Brain Subjected or Not to Caloric Restriction DietPierluigi Cassano, Angela Maria Serena Lezza, Christiaan Leeuwenburgh · 2004 · Annals of the New York Academy of Sciences
- Differential Phenotypes of Active Site and Human Autosomal Dominant Progressive External Ophthalmoplegia Mutations in Drosophila Mitochondrial DNA Helicase Expressed in Schneider CellsYuichi Matsushima, Laurie S. Kaguni · 2007 · Journal of Biological Chemistry
- Do mtDNA deletions drive premature aging in mtDNA mutator mice?Kraytsberg, Yevgenya, Simon, David K., Turnbull, Douglas M., Khrapko, Konstantin · 2009 · Aging Cell
- Structure–function defects of the twinkle amino-terminal region in progressive external ophthalmoplegiaTeresa Holmlund, Géraldine Farge, Vineet Pande, Jenny A. Korhonen, Lennart Nilsson, Maria Falkenberg · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Analysis of the trinucleotide CAG repeat from the DNA polymerase γ gene (POLG) in patients with Parkinson's diseaseJan‐Willem Taanman, Anthony H.V. Schapira · 2004 · Neuroscience Letters
- Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cellsRuhanen, Heini, Ushakov, Kathy, Yasukawa, Takehiro · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Somatic mtDNA mutations and aging – Facts and fanciesAlexandra Kukat, Aleksandra Trifunović · 2008 · Experimental Gerontology
- Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expressionLanying Song, Yuxi Shan, K. C. Kent Lloyd, Gino A. Cortopassi · 2012 · Human Molecular Genetics
- Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesisHalsne, Ruth, Esbensen, Ying, Wang, Wei, Scheffler, Katja, Suganthan, Rajikala, Bjørås, Magnar, Eide, Lars · 2012 · DNA repair
- Parkinsonism associated with the homozygous W748S mutation in the POLG1 geneAnne Marja Remes, Reetta Hinttala, Mikko Kärppä, Heidi K. Soini, R. Takalo, Johanna Uusimaa, Kari Majamaa · 2008 · Parkinsonism & Related Disorders
- On the timing and the extent of clonal expansion of mtDNA deletions: Evidence from single-molecule PCRAlexander Nicholas, Yevgenya Kraytsberg, Xinhong Guo, Konstantin Khrapko · 2009 · Experimental Neurology
- Effect of time of restriction on the decrease in mitochondrial H<sub>2</sub>O<sub>2</sub> production and oxidative DNA damage in the heart of food‐restricted ratsGredilla, R., López‐Torres, M., Barja, G. · 2002 · Microscopy Research and Technique
- Mitochondrial DNA deletions in muscle satellite cells: implications for therapiesSally Spendiff, Mojgan Reza, Julie L. Murphy, Gráinne S. Gorman, Emma L. Blakely, Robert William Taylor, Rita Horváth, Georgia Campbell, Jane H. Newman, Hanns Lochmüller et al. · 2013 · Human Molecular Genetics
- Levels of DNA damage are unaltered in mice overexpressing human catalase in nucleiSchriner, Samuel E, Ogburn, Charles E, Smith, Annette C, Newcomb, Terry G, Ladiges, Warren C, Dollé, Martijn E.T, Vijg, Jan, Fukuchi, Ken-Ichiro, Martin, George M · 2000 · Free Radical Biology and Medicine
- Mitochondrial transcription factor A (TFAM) gene variation in Parkinson's diseaseVictoria Álvarez, Ana I. Corao, Elena Sánchez-Ferrero, Lorena de Mena, Cristina Alonso‐Montes, Cecilia Huerta, Marta Blázquez Estrada, René Ribacoba, Luis M. Guisasola, Carlos Salvador et al. · 2008 · Neuroscience Letters
- Drosophila RNase H1 is essential for development but not for proliferationValery A. Filippov, M. Filippova, S. Gill · 2001 · Molecular Genetics and Genomics
- <i>POLG2</i>disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacityYoung, Matthew J., Humble, Margaret M., DeBalsi, Karen L., Sun, Kathie Y., Copeland, William C. · 2015 · Human Molecular Genetics
- The timing of mitochondrial DNA mutations in agingKonstantin Khrapko · 2011 · Nature Genetics
- Overview of Parkinson's DiseaseRoger C. Duvoisin · 1992 · Annals of the New York Academy of Sciences
- Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defectsSanchez-Martinez, Alvaro, Calleja, Manuel, Peralta, Susana, Matsushima, Yuichi, Hernandez-Sierra, Rosana, Whitworth, Alexander J., Kaguni, Laurie S., Garesse, Rafael · 2012 · PLoS ONE
- Physiological and Biochemical Defects in Carboxyl-terminal Mutants of Mitochondrial DNA HelicaseYuichi Matsushima, Carol L. Farr, Li Fan, Laurie S. Kaguni · 2008 · Journal of Biological Chemistry
- A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunitsCraig, Kate, Young, Matthew J., Blakely, Emma L., Longley, Matthew J., Turnbull, Douglass M., Copeland, William C., Taylor, Robert W. · 2012 · Mitochondrion
- When man got his mt DNA deletions?Konstantin Yu. Popadin, Adeel Safdar, Yevgenya Kraytsberg, Konstantin Khrapko · 2014 · Aging Cell
- The overexpression of twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in miceTanaka, Atsushi, Ide, Tomomi, Fujino, Takeo, Onitsuka, Ken, Ikeda, Masataka, Takehara, Takako, Hata, Yuko, Ylikallio, Emil, Tyynismaa, Henna, Suomalainen, Anu et al. · 2013 · PLoS ONE
- Autosomal dominant mutations in POLG and C10orf2: association with late onset chronic progressive external ophthalmoplegia and Parkinsonism in two patientsBrandon R. Barton, Nico J. Diederich, Madhu Soni, Katrin Witte, Manja Weinhold, Micaela Krause, Sandra Jackson · 2013 · Journal of Neurology
- The in cis T251I and P587L POLG1 base changes: Description of a new family and literature reviewCarmela Scuderi, Eugenia Borgione, Filippa Ida Castello et al. · 2015 · Neuromuscular Disorders
- Polymerase subunit gamma 2 affects porcine oocyte maturation and subsequent embryonic developmentLee, Seul-Ki, Zhao, Ming-Hui, Zheng, Zhong, Kwon, Jung-Woo, Liang, Shuang, Kim, Seon-Hyang, Kim, Nam-Hyung, Cui, Xiang-Shun · 2015 · Theriogenology
- On Mitochondria, Mutations, and MethodologyMarc Vermulst, Jonathan Wanagat, Lawrence A. Loeb · 2009 · Cell Metabolism
- Parkinsonism, cognitive deficit and behavioural disturbance caused by a novel mutation in the polymerase gamma geneManuel Delgado‐Alvarado, Patricia de la Riva, Haritz Jiménez‐Urbieta, Belén Gago, Alazne Gabilondo, Belén Bornstein, María Rodríguez‐Oroz · 2015 · Journal of the Neurological Sciences
- Selective mtDNA mutation accumulation results in β-cell apoptosis and diabetes developmentKenneth Gregory Bensch, Justin L. Mott, Shin-Wen Chang, Polly A. Hansen, Michael A. Moxley, Kari T. Chambers, Wieke Freudenburg-de Graaf, Hans Peter Zassenhaus, John A. Corbett · 2009 · American Journal of Physiology-Endocrinology and Metabolism
- Variations of mitochondrial DNA polymerase γ in patients with Parkinson’s diseaseSusanna Ylönen, Pauli Ylikotila, Ari Siitonen, Saara Finnilä, Jaana M. Autere, Kari Majamaa · 2013 · Journal of Neurology
- Where and When Do Somatic mtDNA Mutations Occur?Konstantin Khrapko, Konstantin K. Ebralidse, Yevgenya Kraytsberg · 2004 · Annals of the New York Academy of Sciences
- A transgenic model to study the pathogenesis of somatic mtDNA mutation accumulation in β‐cellsBensch, K. G., DeGraaf, W., Hansen, P. A., Zassenhaus, H. P., Corbett, J. A. · 2007 · Diabetes Obesity and Metabolism