Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.
Abstract
Aging is associated with a reduction in muscle mass and strength, which compromises functional independence. Skeletal muscle also shows an increase in mitochondrial dysfunction and oxidative stress in older adults. Resistance-exercise training is an important countermeasure for aging-associated muscle weakness. It has been shown that resistance-exercise training increases muscle strength and function in older adults, in association with a reduction in markers of oxidative stress and an improvement in mitochondrial function. Patients with sporadic mitochondrial cytopathies show an accumulation of mitochondrial DNA mutations and deletions in mature muscle, but not in satellite cells. Such patients have shown an activation of the satellite cells following myotoxic trauma and resistance, likely due to a fusion of the relatively quiescent satellite cells with mature muscle, which dilutes the mutational burden, a process called mitochondrial DNA shifting. Preliminary data strongly suggest that mitochondrial DNA shifting occurs in skeletal muscle from older adults following resistance-exercise training.
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Preliminary data suggests that mtDNA shifting also occurs in aging skeletal muscle following resistance exercise training.
“Preliminary data suggests that mtDNA shifting also occurs in aging skeletal muscle following resistance exercise training (Tarnopolsky, 2009).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Tarnopolsky, 2009
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- Authors
- Tarnopolsky, M. A.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Tarnopolsky, M. A.
- ORCID
- Tarnopolsky, M. A.
- Venue
- Applied Physiology Nutrition and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2009-06
- Volume
- 34
- Issue
- 3
- Pages
- 348-354
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2117588500
- Cited by
- 59
- References
- 77
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Baoji University of Arts And Sciences
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- resistance training, older adults, mitochondrial DNA mutations, satellite cells, mitochondrial dysfunction, oxidative stress, sarcopenia, aging, skeletal muscle
- MeSH terms
- Aged, Aging, DNA, Mitochondrial, Humans, Mitochondria, Exercise, Muscle, Skeletal, Resistance Training
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