Cited by 269Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsBiochemical and Molecular Research

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NAD metabolism: Implications in aging and longevity

Yaku, Keisuke, Okabe, Keisuke, Nakagawa, Takashi·2018·Ageing Research Reviews

DOI 10.1016/j.arr.2018.05.006

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Abstract

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous physiological processes, including metabolism, post-translational protein modification, and DNA repair. In living organisms, a careful balance between NAD production and degradation serves to regulate NAD levels. Recently, a number of studies have demonstrated that NAD levels decrease with age, and the deterioration of NAD metabolism promotes several aging-associated diseases, including metabolic and neurodegenerative diseases and various cancers. Conversely, the upregulation of NAD metabolism, including dietary supplementation with NAD precursors, has been shown to prevent the decline of NAD and exhibits beneficial effects against aging and aging-associated diseases. In addition, many studies have demonstrated that genetic and/or nutritional activation of NAD metabolism can extend the lifespan of diverse organisms. Collectively, it is clear that NAD metabolism plays important roles in aging and longevity. In this review, we summarize the basic functions of the enzymes involved in NAD synthesis and degradation, as well as the outcomes of their dysregulation in various aging processes. In addition, a particular focus is given on the role of NAD metabolism in the longevity of various organisms, with a discussion of the remaining obstacles in this research field.

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Authors: Yaku, K., Okabe, K., & Nakagawa, T.
Affiliations: University of Toyama (JP)
Corresponding author: Nakagawa, Takashi
ORCID: Yaku, Keisuke
Okabe, Keisuke
Nakagawa, Takashi
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2018-11
Volume: 47
Pages: 1-17
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2018.05.006
OpenAlex: W2806961305
Semantic Scholar: 9741da16cf47c68fa6c583f4b975e562ebd9ef5d
Cited by: 269
References: 246
Citations by year: 2026: 30 · 2025: 26 · 2024: 39 · 2023: 30 · 2022: 43 · 2021: 41 · 2020: 39 · 2019: 17 · 2018: 4
FWCI: 2.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: JSPS KAKENHI (2460901, 17K08653, 16K21051)
Grant-in-Aid for Scientific Research on Innovative Areas (24116511)
Young Scientists from Japan Society of Nutrition and Food Science
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: NAD+ metabolism, aging, longevity, NAD+ synthesis, NAD+ degradation, NAD+ precursors, NAD+ depletion, age-related diseases, neurodegenerative diseases, metabolic disorders, cancer, lifespan extension, NAD-dependent enzyme, post-translational protein modification, DNA repair
MeSH terms: Aging, Animals, Humans, Longevity, NAD, Neoplasms, Neurodegenerative Diseases

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NAD metabolism: Implications in aging and longevity

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