NAD metabolism: Implications in aging and longevity

Hearing loss and cognitive decline in older adults

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

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Sirtuins as regulators of metabolism and healthspan

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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SIRT1 regulates circadian clock gene expression through PER2 deacetylation

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miR-34a repression of SIRT1 regulates apoptosis

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340

Glaucoma

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NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Molecular inflammation: Underpinnings of aging and age-related diseases

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Circadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1

Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198

Chronic Inflammation in Obesity and the Metabolic Syndrome

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Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects

Badawy, A. A.-B. (2017) · International Journal of Tryptophan Research · doi:10.1177/1178646917691938 · Cited by 1,158

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis

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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.002 · Cited by 1,061

The sirtuin SIRT6 regulates lifespan in male mice

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Cloning and Characterization of the cDNA Encoding a Novel Human pre-B-Cell Colony-enhancing Factor

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

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Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.035 · Cited by 950

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.013 · Cited by 930

Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.003 · Cited by 911

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.006 · Cited by 901

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD + into a nuclear signalPreprint

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The Critical Role of Metabolic Pathways in Aging

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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A. (2003) · Nature · doi:10.1038/nature01578 · Cited by 736

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

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Elevated Plasma Level of Visfatin/Pre-B Cell Colony-Enhancing Factor in Patients with Type 2 Diabetes Mellitus

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The NAD metabolome — a key determinant of cancer cell biology

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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

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The aging clock: circadian rhythms and later life

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Wallerian degeneration: an emerging axon death pathway linking injury and disease

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

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Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

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SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

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Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564

Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration

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Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

Berger, F., Lau, C., Dahlmann, M., & Ziegler, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508660200 · Cited by 508

NAD(+) in aging: molecular mechanisms and translational implications

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Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells

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Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound d -1-Methyl-Tryptophan

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Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

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NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

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TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription

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Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

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Biosensor reveals multiple sources for mitochondrial NAD +

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Epigenetic control of rDNA loci in response to intracellular energy status

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Early age-related changes in adult hippocampal neurogenesis in C57 mice

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NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

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Individual variability in human blood metabolites identifies age-related differences

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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

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Race and Sex Differences in Age‐Related Hearing Loss: The Health, Aging and Body Composition Study

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Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

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Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence

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Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

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MicroRNAs and their roles in aging

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Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

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Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism

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The Role of Cyclic-ADP-Ribose-Signaling Pathway in Oxytocin-Induced Ca2+ Transients in Human Myometrium Cells

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Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo

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Clock Gene Modulation by TNF-α Depends on Calcium and p38 MAP Kinase Signaling

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Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2

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Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila

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Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells

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Depletion of the Central Metabolite NAD Leads to Oncosis-mediated Cell Death

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Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes

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A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys

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Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration

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Natural genetic variation in yeast longevityPreprint

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Plasma visfatin levels and gene expression in morbidly obese women with associated fatty liver disease

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Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses.

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Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo

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Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase

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Pathway analysis of NAD+ metabolism

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Probable mechanisms of regulation of the utilization of dietary tryptophan, nicotinamide and nicotinic acid as precursors of nicotinamide nucleotides in the rat

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Exogenous NAD+ decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy

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Yeast replicative aging: a paradigm for defining conserved longevity interventions

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Changes in Oxidative Damage, Inflammation and [NAD(H)] with Age in Cerebrospinal Fluid

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Protection of Mouse Retinal Ganglion Cell Axons and Soma from Glaucomatous and Ischemic Injury by Cytoplasmic Overexpression of Nmnat1

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CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain

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Nicotinamide Phosphoribosyl Transferase (Nampt) Is a Target of MicroRNA-26b in Colorectal Cancer Cells

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The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.

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Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria

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Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

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Epigenetic regulation of aging: implications for interventions of aging and diseases

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NAD+ metabolism, stemness, the immune response, and cancer

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The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

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Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

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The Warburg Effect 97 Years after Its Discovery

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NAD+ metabolism as a therapeutic target against aging

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THE ROLE OF NAD⁺ AND ITS DERIVATIVES IN METABOLISM AND AGING

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NAD+ Metabolism in Aging

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烟酰胺腺嘌呤二核苷酸（NAD+）合成代谢及其调控机体衰老研究进展

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NAD+ metabolism and its roles in cellular processes during ageing

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