Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
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DEGs linked to non-vulnerable subtypes were enriched for ubiquitin-ligase binding, heat-shock-family chaperones, ER protein processing and mediators of neuronal death, whereas vulnerability-associated DEGs were highly enriched only for mitochondrial oxidative phosphorylation but included CRK and NEUROD2, which are associated with Reelin signalling.
“DEGs linked to non-vulnerable subtypes were enriched for a diverse set of functions, including ubiquitin-ligase binding, heat-shock-family chaperones, ER protein processing and mediators of neuronal death, whereas vulnerability-associated DEGs were highly enriched only for mitochondrial oxidative phosphorylation but included CRK and NEUROD2, which are both associated with Reelin signalling17,18”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [18]
Five excitatory neuron subtypes were reduced in patients with AD (vulnerable subtypes) in the early-affected EC and HC, including EC layer II (L2), RORB-positive L5 (AGBL1+GPC5+) and hippocampal CA1 subfield neurons.
“We identified five excitatory neuron subtypes that were reduced in patients with AD (vulnerable subtypes) in the early-affected EC and HC1,17,18, including EC layer II (L2), RORB-positive L5 (AGBL1+GPC5+)19 and hippocampal CA1 subfield neurons20–23.”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [18]
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Single-cell multiregion dissection of Alzheimer’s disease
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343 · see citing works
Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches
Mary, A., Eysert, F., Checler, F., & Chami, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01631-6 · Cited by 244 · see citing works
Can exercise training teach us how to treat Alzheimer's disease?
Huuha, A. M., Norevik, C. S., Moreira, J. B. N., Kobro-Flatmoen, A., Scrimgeour, N., Kivipelto, M., Van Praag, H., Ziaei, M., Sando, S. B., Wisløff, U., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101559 · Cited by 79 · see citing works
Self-citationZhou, Y., Xu, J., Hou, Y., Bekris, L., Leverenz, J. B., Pieper, A. A., Cummings, J., & Cheng, F. (2022) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12350 · Cited by 39 · see citing works
- Authors
- Kobro-Flatmoen, A., Lagartos-Donate, M. J., Aman, Y., Edison, P., Witter, M. P., & Fang, E. F.
- ORCID
- Witter, Menno P.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 67
- Pages
- 101307
- ISSN
- 1568-1637
- Cited by
- 112
- References
- 45
- Language
- en
- Licence
- Funders
- South-Eastern Norway Regional Health Authority
- National Natural Science Foundation of China
- Research Council of Norway
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