Identification of the human medial temporal lobe regions on magnetic resonance images: Human Medial Temporal Lobe Landmarks
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The medial temporal lobe (MTL) plays a key role in learning, memory, spatial navigation, emotion, and social behavior. The improvement of noninvasive neuroimaging techniques, especially magnetic resonance imaging, has increased the knowledge about this region and its involvement in cognitive functions and behavior in healthy subjects and in patients with various neuropsychiatric and neurodegenerative disorders. However, cytoarchitectonic boundaries are not visible on magnetic resonance images (MRI), which makes it difficult to identify precisely the different parts of the MTL (hippocampus, amygdala, temporopolar, perirhinal, entorhinal, and posterior parahippocampal cortices) with imaging techniques, and thus to determine their involvement in normal and pathological functions. Our aim in this study was to define neuroanatomical landmarks visible on MRI, which can facilitate the examination of this region. We examined the boundaries of the MTL regions in 50 post-mortem brains. In eight cases, we also obtained post-mortem MRI on which the MTL boundaries were compared with histological examination before applying them to 26 in vivo MRI of healthy adults. We then defined the most relevant neuroanatomical landmarks that set the rostro-caudal limits of the MTL structures, and we describe a protocol to identify each of these structures on coronal T1-weighted MRI. This will help the structural and functional imaging investigations of the MTL in various neuropsychiatric and neurodegenerative disorders affecting this region.
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The anterior HF, posterior HF, PRC, and PHC were manually segmented according to previously published guidelines.
“The anterior HF (HF head), posterior HF (HF body and tail), PRC, and PHC were manually segmented on the MPRAGE coronal plane according to previously published guidelines (Insausti et al., 1998; Franko et al., 2014).”
From Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval (2015) · cites this paper as Franko et al., 2014
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Awareness of what is learned as a characteristic of hippocampus-dependent memory
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Sparing of spatial mental imagery in patients with hippocampal lesionsPreprint
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Allocentric representation in the human amygdala and ventral visual stream
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Automated segmentation of the human hippocampus along its longitudinal axis
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Medial temporal lobe and topographical memory
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Representations of Complex Contexts: A Role for Hippocampus
Dimsdale-Zucker, H. R., Montchal, M. E., Reagh, Z. M., Wang, S.-F., Libby, L. A., & Charan Ranganath, A. (2022) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01919 · Cited by 14 · see citing works
How landmark suitability shapes recognition memory signals for objects in the medial temporal lobes
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Animacy and real‐world size shape object representations in the human medial temporal lobes
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Preserved capacity for scene construction and shifts in perspective after hippocampal lesionsPreprint
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Changes in spatial self-consciousness elicit grid cell–like representation in the entorhinal cortex
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Medial Temporal Lobe Damage Impairs Temporal Integration in Episodic Memory
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Spared Perception of the Structure of Scenes after Hippocampal Damage
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Spared perception of object geometry and object components after hippocampal damagePreprint
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PhyloBrain atlas: a cortical brain MRI atlas following a phylogenetic approachPreprint
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Representation of Task Structure in Human Hippocampus and Orbitofrontal CortexPreprint
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- Authors
- Frankó, E., Insausti, A. M., Artacho-Pérula, E., Insausti, R., & Chavoix, C.
- Affiliations
- Inserm (FR)
- Department of Health, Physical Therapy School; Public University of Navarra; Tudela Spain
- Human Neuroanatomy Laboratory; School of Medicine; University of Castilla-La Mancha; Albacete Spain
- University of Castilla-La Mancha (ES)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2012-08-30
- Volume
- 35
- Issue
- 1
- Pages
- 248-256
- ISSN
- 1065-9471 (ISSN-L)
- PMC
- PMC6869625
- OpenAlex
- W1581703214
- Cited by
- 85
- References
- 64
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 11
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Keywords
- medial temporal lobe, hippocampus, amygdala, parahippocampal cortex, entorhinal cortex, perirhinal cortex, postmortem MRI
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Temporal Lobe
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