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Cited by 66Alcohol Consumption and Health EffectsInflammatory Biomarkers in Disease PrognosisNutritional Studies and Diet

Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health Study

Mukamal, Kenneth J, Cushman, Mary, Mittleman, Murray A, Tracy, Russell P, Siscovick, David S·2004·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2003.10.011
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Abstract

Objective We sought to determine the relation of alcohol intake and systemic inflammation in a population-based sample of older adults.Methods and results As part of the Cardiovascular Health Study (CHS), 5865 adults aged 65 years and older reported their intake of beer, wine, and liquor. We determined white blood cell count (WBC), factor VIII coagulant activity (factor VIIIc), and levels of C-reactive protein (CRP), fibrinogen, and albumin as markers of systemic inflammation. Among participants without confirmed cardiovascular disease, alcohol consumption was inversely associated with WBC, factor VIIIc, and fibrinogen level, and positively associated with albumin concentration in multivariate analyses. We found no consistent modification of these results by sex, obesity, or beverage type. The relation of alcohol use and CRP levels was significantly modified by apoE genotype (P interaction 0.03), with a positive association among participants with an apoE4 allele (P = 0.05), but a trend toward an inverse association among those without an apoE4 allele (P = 0.15).Conclusions Alcohol intake is associated with lower levels of inflammatory markers in older adults free of cardiovascular disease.

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Crossref · 10.1016/j.atherosclerosis.2003.10.011

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  • Shea et al. reported no significant association between plasma vitamin D concentration and CRP, fibrinogen, TNF-α, IL-6, sTNFR2, sICAM-1, MCP-1, sP-selectin or sCD40 ligand in almost 1400 American adults with a mean age of 59 years.

    “Shea et al. (741) reported no significant association between plasma vitamin D concentration and concentrations of CRP, fibrinogen, TNF-a, IL-6, sTNFR2, sICAM-1, MCP-1, sP-selectin and sCD40 ligand in almost 1400 American adults with a mean age of 59 years.”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [741]

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Authors
Mukamal, K. J., Cushman, M., Mittleman, M. A., Tracy, R. P., & Siscovick, D. S.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • University of Vermont (US)
  • University of Washington (US)
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2004-03
Volume
173
Issue
1
Pages
79-87
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2003.10.011
OpenAlex
W2072415197
Cited by
65
References
44
Citations by year
2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 6
FWCI
5.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc085082-026, n01hc085081-021, n01hc085079-024, n01hc085084-005, n01hc085085-011, n01hc085083-027, n01hc085080-026, n01hc085086-022, 5k23aa000299-04, n01hc035129-010)
  • National Institute on Alcohol Abuse and Alcoholism (K23AA00299)
  • National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85085, N01HC-85083, N01HC85082, N01 HC85086, N01HC85080, N01-HC-15013, N01-HC85079, ­N01-HC85084, N01HC35129)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
alcohol consumption, systemic inflammation, older adults, C-reactive protein, fibrinogen, white blood cell count, factor VIII coagulant activity, albumin, APOE genotype, APOE ε4, cardiovascular disease, Cardiovascular Health Study
MeSH terms
Aged, Aged, 80 and over, Alcohol Drinking, Apolipoproteins E, C-Reactive Protein, Coronary Artery Disease, Female, Fibrinogen, Humans, Leukocyte Count, Longitudinal Studies, Male, Probability, Prospective Studies, Sensitivity and Specificity, Severity of Illness Index, Geriatric Assessment, Logistic Models, Risk Assessment, Inflammation Mediators

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